Common Cavity Research Articles

Retrospective Analysis of Cerebrospinal Gushers in Cochlear Implant Surgery: Incidence, Risk Factors, and Outcomes-A Systematic Review and Meta-analysis.

Background: Cerebrospinal fluid (CSF) gusher is a common complication experienced during cochlear implantation in patients with structural deformities in the inner ear. Objectives: This study aimed to investigate the incidence of CSF gusher, risk factors, and outcomes in patients during cochlear implantation. Methods: This systematic review and meta-analysis were guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses model. Studies used in the analysis were identified through a comprehensive search in Google Scholar and PubMed. Results: The analysis was performed using 13 retrospective studies. The incidence of CSF gusher was 5% (95% CI: 3%-9%). CSF gusher was more prevalent among patients with inner-ear malformation (IEM) than without IEM odds ratio = 63.01 (95% CI: 9.85-403.11, P < .00001, I2 = 88%). For incomplete partition (IP), CSF gusher in the IP-I group was 48% (95% CI: 25%-71%, I2 = 0%), 19% in IP-II, 86% in IP-III, 40% in the common cavity, 26% in cochlear hypoplasia, and 27% in patients with enlarged vestibula aqueduct. Conclusion: The CSF gusher incidences were determined to be 5%. Patients with IEM are at increased risk of experiencing CSF gusher during cochlear implant surgery. Therefore, precise scanning reports should be produced in preoperational phase to inform proper management techniques to reduce the chances of intraoperative complications, including CSF gusher.

Real-time monitoring of urban roadway health: Utilizing GPR techniques for the early detection and classification of subsurface cavity diseases

The effectiveness of ground penetrating radar (GPR) in identifying and categorizing diseases that occur underground beneath the surfaces of urban roads is investigated in this study. Both 2D and 3D forward modeling use simulation with the GprMax program to show the response characteristics of common cavity illnesses, which facilitates interpretation in practical situations. The cavity morphology classification accuracy is improved to 90.5% by using convolutional neural networks (CNNs), specifically transfer learning with AlexNet. This method outperforms existing approaches even with minimal data. Four primary types are identified from an analysis of 1965 subsurface cavity data: hollow bodies, empty bodies, loose bodies, and water-rich bodies. These categories are important for evaluating road risks such as voids and subsidence. However, it is still difficult to interpret picture features linked to cavity diseases accurately because of a variety of elements, such as anthropogenic, environmental, and geological influences. However, the accurate interpretation and recognition of image features related to cavity diseases remain challenging. Moreover, there are various factors involved in the formation of underground diseases and cavities, including geological and environmental factors, physical and chemical properties of the geotechnical materials, anthropogenic engineering activity and social population or commercial effects.

Scalable multiphoton generation from cavity-synchronized single-photon sources

We propose an efficient, scalable, and deterministic scheme to generate multiple indistinguishable photons over independent channels, on demand. Our design relies on multiple single-photon sources, each coupled to a waveguide, all interacting with a common cavity mode. The cavity synchronizes and triggers the simultaneous emission of one photon by each source, which are collected by the waveguides. In a state-of-the-art circuit QED implementation, this scheme supports the creation of single photons with 99% purity, indistinguishability, and efficiency at rates of ∼MHz. We also discuss conditions to produce up to 100 photons simultaneously with generation rates of hundreds of kHz. This is orders of magnitude more efficient than previous demultiplexed sources for boson sampling and enables the realization of deterministic multiphoton sources and scalable quantum information processing with photons. Published by the American Physical Society 2024

Immune mediators in heart-lung communication.

It is often the case that serious, end-stage manifestations of disease result from secondary complications in organs distinct from the initial site of injury or infection. This is particularly true of diseases of the heart-lung axis, given the tight anatomical connections of the two organs within a common cavity in which they collectively orchestrate the two major, intertwined circulatory pathways. Immune cells and the soluble mediators they secrete serve as effective, and targetable, messengers of signals between different regions of the body but can also contribute to the spread of pathology. In this review, we discuss the immunological basis of interorgan communication between the heart and lung in various common diseases, and in the context of organ crosstalk more generally. Gaining a greater understanding of how the heart and lung communicate in health and disease, and viewing disease progression generally from a more holistic, whole-body viewpoint have the potential to inform new diagnostic approaches and strategies for better prevention and treatment of comorbidities.

Unidirectional amplification in the frozen mode regime enabled by a nonlinear defect.

A stationary inflection point (SIP) is a spectral singularity of the Bloch dispersion relation ω(k) of a periodic structure where the first and the second derivatives of ω with respect to k vanish. An SIP is associated with a third-order exceptional point degeneracy in the spectrum of the unit-cell transfer matrix, where there is a collapse of one propagating and two evanescent Bloch modes. At the SIP frequency, the incident wave can be efficiently converted into the frozen mode with greatly enhanced amplitude and vanishing group velocity. This can be very attractive for applications, including light amplification. Due to its non-resonant nature, the frozen mode regime (FMR) has fundamental advantages over common cavity resonances. Here, we propose, a novel, to the best of our knowledge, scheme for FMR-based unidirectional amplifiers by leveraging a tailored amplification/attenuation mechanism and a single nonlinear defect. The defect breaks the directional symmetry of the periodic structure and enables nonlinearity-related unidirectional amplification/attenuation in the vicinity of the SIP frequency. We demonstrate the robustness of the amplification mechanism to local impurities and parasitic nonlinearity.

The imaging appearances of stapical footplate fistula related to inner ear malformation

Objective: To summarize the HRCT and MRI appearances of stapical footplate fistula related to inner ear malformation (SFF-Re-IEM). Methods: The HRCT and MRI materials of 48 cases (53 ears) SFF-Re-IEM were retrospectively analyzed. Among them, 25 SFF-Re-IEM ears were confirmed by surgery. Their CT and MRI findings including associated IEM type, internal auditory canal (IAC) malformation, tympanic fluid, its density and signal features, and accompanied labyrinthitis were recorded. Results: Among 48 cases (53 ears) with SFF-Re-IEM, 17 ears with incomplete partition type Ⅰ, accounting for 32.1%, 13 ears with common cavity for 24.5%, 13 ears with cochlear aplasia for 24.5%, 7 ears with cochlear dysplasia Ⅱ for 13.2%, and 3 ears with Mondini for 5.7%,were found respectively. 94.3% of them were associated with a defect or dysplasia in the found of the IAC. They were divided into 4 types according to the intact of the stapical footplate and accompanied CSF otorrhea: 22 ears were diagnosed as the stapical footplate leaking, of them, 2 ears might come from the stapical footplate bony defect, 6 ears were from the stapical footplate hernia. 1 ear belonged to the peristapical footplate leaking. 30 ears with the isolated the stapical footplate hernia were another found. The bony defect in 2 ears with the stapical footplate bony defect were not presented on CT and MRI.The focal bony defect of the affected stapical footplate of 36 ears with the stapical footplate hernia were demonstrated, which presented the hemispherical protruding into the tympana, the soft-tissue density on CT, and CSF-like signal on the MR heaved-T2WI images. Among 22 ears with the stapical footplate leaking, their imaging appearances varied from the different amount of the leaking CSF. Besides the focal bony defects of the affected stapical footplates, there were much more CSF-like density or signal in the ipsilateral tympanic cavity in 17 affected ears connecting with the vestibule through the defect area. In the CSF leaking ears with less CSF leaking in 5 ears, the CSF-like cysts like SFH were shown on the stapical footplate defect area, but their outer edges were irregular, and the CSF-like signal scattering in the tympanic cavity did not connect with the protruding cysts at the stapical area. Conclusion: The variable appearances of the SFF-Re-IEM ears based on the different subtypes are its characteristic HRCT and MRI appearances. This is helpful for the SFF-Re-IEM diagnosing to grasp its imaging features.

High‐isolation single‐layer dual‐mode substrate‐integrated waveguide diplexers for millimetre‐wave applications

AbstractNew coupling scheme substrate‐integrated waveguide (SIW) diplexers based on dual‐mode cavities are proposed for millimetre‐wave applications. Dual‐mode SIW cavities are simultaneously employed in common input and coupling cavity to produce filtering transmission poles and transmission zero (TZ). A common input SIW cavity with two orthogonal modes is employed instead of the traditional T‐junction for circuit miniaturisation, insertion‐loss reduction, and intrinsically high isolation. A critical dual‐mode SIW cavity with diagonally distributed modes has been employed in each channel to realise a controllable stopband TZ for high selectivity of passband's skirt. To further improve channel isolation and passbands' selectivity, a SIW diplexer based on dual‐ and single‐mode cavities is proposed, and four‐pole responses for each passband channel are designed. For the verification, two millimetre‐wave diplexers have been fabricated and tested.

Anomalous Purcell decay of strongly driven inhomogeneous emitters coupled to a cavity

We perform resonant fluorescence lifetime measurements on a nanocavity-coupled erbium ensemble as a function of cavity-laser detuning and pump power. Our measurements reveal an anomalous three-fold suppression of the ensemble Purcell factor at zero cavity detuning and high pump fluence. We capture qualitative aspects of this decay rate suppression using a Tavis–Cummings model of non-interacting spins coupled to a common cavity.

Insights into the Chemistry, Structure, and Biological Activity of Human Salivary MUC7 Fragments and Their Cu(II) and Zn(II) Complexes.

Mucin 7 (MUC7) is one of the salivary proteins whose role in the innate immune system is widely known, but still, neither its mechanism of action nor the impact of its metal coordination is fully understood. MUC7 and its fragments demonstrate potent antimicrobial activity, serving as a natural defense mechanism for organisms against pathogens. This study delves into the bioinorganic chemistry of MUC7 fragments (L1─EGRERDHELRHRRHHHQSPK; L2─EGRERDHELRHRR; L3─HHHQSPK) and their complexes with Cu(II) and Zn(II) ions. The antimicrobial characteristics of the investigated peptides and their complexes were systematically assessed against bacterial and fungal strains at pH 5.40 and pH 7.40. Our findings highlight the efficacy of these systems against Streptococcus sanguinis, a common oral cavity pathogen. Most interestingly, Zn(II) coordination increased (or triggered) the MUC7 antimicrobial activity, which underscores the pivotal role of metal ion coordination in governing the antimicrobial activity of human salivary MUC7 fragments against S. sanguinis.

Penyuluhan dan Pelatihan Pemeliharaan Kesehatan Gigi dan Mulut Kader PKK dan Posyandu Kelurahan Grogol, Kecamatan Grogol Petamburan, Jakarta

The prevalence of oral health problems in the Jakarta Special Capital Region (DKI Jakarta) according to the Basic Health Research (Riskesdas) results in 2018 was 59.1%. Pericoronitis and periodontal disease are common oral cavity issues. Knowledge about maintaining oral health is a key factor in achieving a good quality of life. To increase public understanding of the importance of dental and oral care, this knowledge program is designed to provide holistic and practical information. Therefore, education in the form of counseling and training is needed by directly engaging with the community to emphasize the importance of dental and oral health care, targeting mothers from the Family Welfare Movement (PKK) and Integrated Health Service Post (Posyandu) cadres in the Grogol sub-district. The results show a significant difference between pre-test and post-test (p &lt; 0.0001). In conclusion, the knowledge of participants improves after receiving counseling and training.

Momentum-exchange interactions in a Bragg atom interferometer suppress Doppler dephasing.

Large ensembles of laser-cooled atoms interacting through infinite-range photon-mediated interactions are powerful platforms for quantum simulation and sensing. Here we realize momentum-exchange interactions in which pairs of atoms exchange their momentum states by collective emission and absorption of photons from a common cavity mode, a process equivalent to a spin-exchange or XX collective Heisenberg interaction. The momentum-exchange interaction leads to an observed all-to-all Ising-like interaction in a matter-wave interferometer. A many-body energy gap also emerges, effectively binding interferometer matter-wave packets together to suppress Doppler dephasing in analogy to Mössbauer spectroscopy. The tunable momentum-exchange interaction expands the capabilities of quantum interaction-enhanced matter-wave interferometry and may enable the realization of exotic behaviors, including simulations of superconductors and dynamical gauge fields.

Computed tomography multi-planar and 3D image assessment protocol for detailed analysis of inner ear malformations in patients undergoing cochlear implantation counseling.

&lt;b&gt;&lt;br&gt;Introduction:&lt;/b&gt; Congenital inner ear malformations resulting from embryogenesis may be visualized in radiological scans. Many attempts have been made to describe and classify the defects of the inner ear based on anatomical and radiological findings.&lt;/br&gt; &lt;b&gt;&lt;br&gt;Aim:&lt;/b&gt; The aim was to propose and discuss computed tomography multi-planar and 3D image assessment protocols for detailed analysis of inner ear malformations in patients undergoing cochlear implantation counseling.&lt;/br&gt; &lt;b&gt;&lt;br&gt;Material and methods:&lt;/b&gt; A retrospective analysis of 22 malformed inner ears. CT scans were analyzed using the Multi-Planar Reconstruction (MPR) option and 3D reconstruction.&lt;/br&gt; &lt;b&gt;&lt;br&gt;Results:&lt;/b&gt; The protocol of image interpretation was developed to allow reproducibility for evaluating each set of images. The following malformations were identified: common cavity, cochlear hypoplasia type II, III, and IV, incomplete partition type II and III, and various combinations of vestibule labyrinth malformations. All anomalies have been presented and highlighted in figures with appropriate descriptions for easier identification. Figures of normal inner ears were also included for comparison. 3D reconstructions for each malformation were presented, adding clinical value to the detailed analysis.&lt;/br&gt; &lt;b&gt;&lt;br&gt;Conclusions:&lt;/b&gt; Properly analyzing CT scans in cochlear implantation counseling is a necessary and beneficial tool for appropriate candidate selection and preparation for surgery. As proposed in this study, the unified scans evaluation scheme simplifies the identification of malformations and reduces the risk of omitting particular anomalies. Multi-planar assessment of scans provides most of the necessary details. The 3D reconstruction technique is valuable in addition to diagnostics influencing the decision-making process. It can minimize the risk of misdiagnosis. Disclosure of the inner ear defect and its precise imaging provides detailed anatomical knowledge of each ear, enabling the selection of the appropriate cochlear implant electrode and the optimal surgical technique.&lt;/br&gt.

Intraoperative EABR Testing Predicts Strength of Cochlear Implant Stimulation Optimized After Long-Term Use in Pediatric Malformation Ears.

This study focused on the intensities of cochlear implant (CI) stimulation in pediatric CI users with inner ear malformation or cochlear nerve deficiency (CND). In this population, CI programming is difficult because a large intensity of CI stimulation is required to achieve sufficient hearing, but the excess CI stimuli often induce facial nerve stimulation. We aimed to assess whether the results of intraoperative electrically evoked auditory brainstem responses (EABRs) testing predict maximum current levels of CI stimuli (cC levels) optimized by a behavioral-based method after long-term CI use. A retrospective case review. A tertiary referral CI center. A total of 116 ears with malformations (malformation group) and 63 control ears (control group) from patients younger than 18 years who received CI. The malformation group comprised 23 ears with a common cavity (CC), 26 with incomplete partition type 1 (IP-1), 26 with incomplete partition type 2 (IP-2), and 41 with CND. Diagnostic. Correlation between intraoperative EABR results and cC levels determined by the behavioral-based CI programming after long-term CI use. The CC, IP-1, and CND ears required significantly larger cC levels than the IP-2 ears and control groups. However, the cC levels increased to reach the plateau 1 year after surgery in all groups. Among the malformation group, 79 ears underwent intraoperative EABR testing. Greater than 80% of the CC, IP-1, and IP-2 ears and 54.8% of the CND ears exhibited evoked wave V (eV) and were included in the eV-positive category. Myogenic responses but no eV were observed in 18.2, 15.0, and 35.5% of the CC, IP-1, and CND ears, defined as the myogenic category. No eV or myogenic response was elicited in 9.7% of the CND ears. We focused on minimum current levels that elicited eV (eV levels) in the eV-positive category and maximum current levels that did not elicit any myogenic responses (myogenic levels) in the myogenic category. A significant relationship was detected between the eV levels and the cC levels. When analyzed in each malformation type, the eV levels significantly correlate with the cC levels in the CC and CND ears but not in the IP-1 and IP-2 ears, probably because of slight variation within the IP-1 group and the small number of the IP-2 group. The myogenic category did not show a significant relationship between the myogenic levels and cC levels, but the cC levels were similar to or smaller than the myogenic levels in most ears. This study confirmed that intraoperative EABR testing helps predict the optimal cC levels in malformation ears. EABR-based CI programming immediately after cochlear implantation, followed by behavioral-based CI programming, may allow us to achieve early postoperative optimization of CI maps even in young children with severe malformations.

Compact Integrated Circular Polarization Filtering Antenna based on SIW Cavity

In this paper, a compact integrated circular polarization filtering antenna is proposed based on substrate integrated waveguide (SIW) cavity. Firstly, a dual-mode (TE102 and TE201 modes) rectangular cavity is utilized as a common feeding cavity to achieve a dual-mode filtering response. And then, an additional rectangular patch with a slot is coupled from the feeding cavity for circular polarization radiation. To verify the proposed concept, a prototype circular polarization filtering antenna is simulated. The circular polarized filtering antenna resonates at 4.225 GHz with a low cross-polarization and a high gain of 7.23 dBi.

Construction of diverse hollow MFI zeolites through regulating the micropore filling agents

Constructing hollow structure into microporous zeolites can improve the accessibility of acid sites located at the inner part and the diffusion property. Hence, the development of an efficient synthesis strategy to acquire zeolites with tunable hollow structures and acidity has attracted much attention. In this work, an innovative tandem synthesis route was proposed to prepare MFI zeolites with diverse hollow structure while maintaining solid yields exceeding 90 %. The substitution of ethanol molecules, which previously occupied the micropores, with tetrapropylammonium cations was proved to be the key factor to construct hollow structure. And a crystallization-driven particle dissolution mechanism was proposed. The dimension of the hollow cavity, particle size, and Si/Al ratio can be flexibly regulated. Interestingly, hollow MFI samples featuring the common cavity structure, “eye-like” cavity structure, or double-cavity structure can be directly synthesized by controlling the dissolution of core parts. In the 1-butene catalytic cracking reactions, a much higher conversion of 67.2 % was acquired over hollow ZSM-5 compared with that over conventional ZSM-5 (35.8 %) after 64 h of reaction. This improvement can be attributed to the eightfold increase of diffusivity in hollow ZSM-5. This facile and efficient synthesis method endows accurate regulation of the hollow structure, which is meaningful for both fundamental research and industrial applications of hollow zeolites.

Unconditional Wigner-negative mechanical entanglement with linear-and-quadratic optomechanical interactions

The generation of entangled states that display negative values of the Wigner function in the quantum phase space is a challenging task, particularly elusive for massive, and possibly macroscopic, systems such as mechanical resonators. In this work, we propose two schemes based on reservoir engineering for generating Wigner-negative entangled states unconditionally. We consider two noninteracting mechanical resonators that are radiation-pressure coupled to either one or two common cavity fields; the optomechanical coupling with the field(s) features both a linear and quadratic part in the mechanical displacement and the cavity is driven at multiple frequencies. We show analytically that both schemes stabilize a Wigner-negative entangled state that combines the entanglement of a two-mode squeezed vacuum with a cubic nonlinearity, which we dub cubic-phase entangled (CPE) state. We then perform extensive numerical simulations to test the robustness of Wigner-negative entanglement attained by approximate CPE states stabilized in the presence of thermal decoherence. Published by the American Physical Society 2024

Using formalin fixed paraffin embedded tissue to characterize the microbiota in p16-positive and p16-negative tongue squamous cell carcinoma: a pilot study

BackgroundTongue squamous cell carcinoma (TSCC) is the most common oral cavity cancer, and p16 immunohistochemistry is an exact and available tool in the prognostic and predictive characterization of squamous cell cancers in the head and neck. Microorganisms have a close relationship with the development of TSCC. However, the association between oral bacteria and p16 status has not been well defined in the case of TSCC. Compared with traditional clinical microbial collection methods, formalin-fixed paraffin-embedded (FFPE) tissue samples have several advantages.MethodsTo compare the microbiota compositions between p16-positive and p16-negative patients with TSCC, we performed a small pilot study of microbiological studies of TSCC by paraffin tissue. DNA from FFPE tissue blocks were extracted and microbiomes were profiled by sequencing the 16 S-rRNA-encoding gene (V1–V2/V3-V4/V4 regions). Alterations in the functional potential of the microbiome were predicted using PICRUSt, Tax4Fun, and BugBase.ResultsA total of 60 patients with TSCC were enrolled in the study, however, some challenges associated with DNA damage in FFPE tissues existed, and only 27 (15 p16-positive and 12 p16-negative) passed DNA quality control. Nevertheless, we have tentatively found some meaningful results. The p16 status is associated with microbiota diversity, which is significantly increased in p16-positive patients compared with p16-negative patients. Desulfobacteria, Limnochordia, Phycisphaerae, Anaerolineae, Saccharimonadia and Kapabacteria had higher abundances among participants with p16-positive. Moreover, functional prediction revealed that the increase of these bacteria may enhance viral carcinogenesis in p16-positive TSCC.ConclusionsBacterial profiles showed a significant difference between p16-positive TSCC and p16-negative TSCC. These findings may provide insights into the relationship between p16 status and the microbial taxa in TSCC, and these bacteria may provide new clues for developing therapeutic targets for TSCC.

A novel radiological software prototype for automatically detecting the inner ear and classifying normal from malformed anatomy

BackgroundTo develop an effective radiological software prototype that could read Digital Imaging and Communications in Medicine (DICOM) files, crop the inner ear automatically based on head computed tomography (CT), and classify normal and inner ear malformation (IEM). MethodsA retrospective analysis was conducted on 2053 patients from 3 hospitals. We extracted 1200 inner ear CTs for importing, cropping, and training, testing, and validating an artificial intelligence (AI) model. Automated cropping algorithms based on CTs were developed to precisely isolate the inner ear volume. Additionally, a simple graphical user interface (GUI) was implemented for user interaction. Using cropped CTs as input, a deep learning convolutional neural network (DL CNN) with 5-fold cross-validation was used to classify inner ear anatomy as normal or abnormal. Five specific IEM types (cochlear hypoplasia, ossification, incomplete partition types I and III, and common cavity) were included, with data equally distributed between classes. Both the cropping tool and the AI model were extensively validated. ResultsThe newly developed DICOM viewer/software successfully achieved its objectives: reading CT files, automatically cropping inner ear volumes, and classifying them as normal or malformed. The cropping tool demonstrated an average accuracy of 92.25%. The DL CNN model achieved an area under the curve (AUC) of 0.86 (95% confidence interval: 0.81-0.91). Performance metrics for the AI model were: accuracy (0.812), precision (0.791), recall (0.8), and F1-score (0.766). ConclusionThis study successfully developed and validated a fully automated workflow for classifying normal versus abnormal inner ear anatomy using a combination of advanced image processing and deep learning techniques. The tool exhibited good diagnostic accuracy, suggesting its potential application in risk stratification. However, it is crucial to emphasize the need for supervision by qualified medical professionals when utilizing this tool for clinical decision-making.

Cavity-induced bifurcation in classical rate theory

We show how coupling an ensemble of bistable systems to a common cavity field affects the collective stochastic behavior of this ensemble. In particular, the cavity provides an effective interaction between the systems, and parametrically modifies the transition rates between the metastable states. We predict that the cavity induces a phase transition at a critical temperature which depends linearly on the number of systems. It shows up as a spontaneous symmetry breaking where the stationary states of the bistable system bifurcate. We observe that the transition rates slow down independently of the phase transition, but the rate modification vanishes for alternating signs of the system-cavity couplings, corresponding to a disordered ensemble of dipoles. Our results are of particular relevance in polaritonic chemistry where the presence of a cavity has been suggested to affect chemical reactions.

Controlling Remote Entanglement and One‐Way Steering Via a Squeezed Vacuum Field and an Optical Parametric Amplifier

AbstractA scheme is proposed for generating remote entanglement and one‐way Einstein‐Podolsky‐Rosen (EPR) steering between two mechanical resonators in a cavity optomechanical system. Both mechanical resonators are coupled to a common cavity, which contains an optical parametric amplifier (OPA) and is driven by a squeezed vacuum field. The entanglement and EPR steering can be generated by the squeezed vacuum field and significantly enhanced by the gain of OPA. By manipulating the ratio of two effective optomechanical coupling strengths, the asymmetric EPR steering with excellent controllability on the direction, even the one‐way EPR steering can be achieved. Moreover, both the squeezed vacuum field and the OPA can effectively enhance the robustness of EPR steering against the environment temperature, and the temperature‐dependent one‐way EPR steering is explored. This work paves the way toward generating macroscopic mechanical entanglement and EPR steering with potential applications in quantum information processing.