The optimization of a hypersonic glide vehicle’s reachable domain is studied using different models to constrain the stagnation-point heat transfer. The vehicle is modeled as a high-lift common aero vehicle that uses bank-angle modulation for crossrange maneuvering with a leading-edge thermal protection system made of an ultra-high-temperature ceramic. A constrained nonlinear optimization problem is formulated to determine the range of feasible trajectories that satisfy aerodynamic heating and loading constraints. The optimal control profile is determined using a modified particle swarm optimization routine that employs a penalty function approach to handle path and terminal constraints. Baseline trajectories are determined using an existing convective heat-flux correlation, and the effect of surface catalycity on the optimized trajectories is investigated by applying a correction factor, derived from high-fidelity computational fluid dynamics simulations, to the heat-flux correlation. Results demonstrate a high sensitivity of the optimized trajectories to the underlying aerothermodynamics model such that accounting for surface catalycity expands the reachability by an order of magnitude.