Commercial Statistical Software Research Articles

OPTIC PATHWAY GLIOMAS AFTER TRANSITIONING INTO ADULTHOOD – AN INSTITUTIONAL EXPERIENCE

Abstract AIMS Optic pathway gliomas (OPG) are rare tumors affecting the optic nerve and the chiasm that occur predominantly during childhood and are generally managed by pediatric neurosurgeons/ pediatric oncologists. Prognosis is quite good for these benign tumors, and many patients survive into adulthood. While clinical care for these patients in childhood is well-standardized, the clinical course of patients with OPG after transitioning into adulthood is not well studied.We herein aimed to characterize patients with OPG diagnosed in childhood after transitioning into adult neurosurgical care in order in order to ellucidate the clinical course of OPG in adulthood and to identify potential problems with clinical care of these special patients in adult neurosurgery or neuro-oncology services. METHOD Clinical and radiographical data from adult patients (> 16 years of age) with OPG diagnosed in childhood and treated in our institution were collected from patient charts. Descriptive statistics and outcome analysis were performed using commercial statistical software. RESULTS Of 124 patients with OPG diagnosed in childhood, 35 patients transitioned into adulthood. The population included equal distribution of male (18, 51.4%) vs female (17, 48.6%) patients. Median age at diagnosis was 8.0 years (range 0.5 – 15.0) and median age at last follow up was 20.8 years (range 17.1 – 38.6). 12 patients were positive for NF (34.3%). 9 patients had undergone surgery for the OPG (25.7%), 11 had chemotherapy (31.4%) and 15 (42.8%) had received radiotherapy. 8 patients showed an endocrine deficiency (22.9%), 4 hypothalamic dysfunction (11.4%) and 8 cognitive/behavioral difficulties (22.9%). Visual acuity impairment was detected in 12 patients (34.3%). 9 patients experienced recurrence (25.7%). CONCLUSION Patients with OPG transition into adulthood frequently and experience a wide range of clinical problems. Close neurosurgical/neuro-oncology specialist follow-up is recommendable.

A Guide to Network Meta-Analysis Using Generative AI and No-Code Tools

Network meta-analysis (NMA), an increasingly appealing method of statistical analysis, is superior to traditional analysis methods in terms of being able to compare multiple medical treatment methods in one analysis run. In recent years, the prevalence of NMA in the medical literature has increased significantly, while advances in NMA-related statistical methods and software tools continue to improve the effectiveness of this approach. Various commercial and free statistical software packages, some of which employ generative artificial intelligence (GAI) to generate code, have been developed for NMA, leading to numerous innovative developments. In this paper, the use of generative AI for writing R programming language scripts and the netmeta package for performing NMA are introduced. Also, the web-based tool ShinyNMA is introduced. ShinyNMA allows users to conduct NMA using an intuitive "clickable" interface accessible via a standard web browser, with visual charts employed to present results. In the first section, we detail the netmeta package documentation and use ChatGPT (chat generative pre-trained transformer) to write the R scripts necessary to perform NMA with the netmeta package. In the second section, a user interface is developed using the Shiny package to create a ShinyNMA tool. This tool provides a no-code option for users unfamiliar with programming to conduct NMA statistical analysis and plotting. With appropriate prompts, ChatGPT can produce R scripts capable of performing NMA. Using this approach, an NMA analysis tool is developed that meets the research objectives, and potential applications are demonstrated using sample data. Using generative AI and existing statistical packages or no-code tools is expected to make conducting NMA analysis significantly easier for researchers. Moreover, greater access to results generated by NMA analyses will enable decision-makers to review analysis results intuitively in real-time, enhancing the importance of statistical analysis in medical decision-making. Furthermore, enabling non-specialists to conduct clinically meaningful systematic reviews may be expected to sustainably improve analytical capabilities and produce higher-quality evidence.

“Comprehensive Integration” Method Based on the Bayesian Network and the Big Data Using in the Construction of New Energy System

With the continuous application of the big data technology, “Comprehensive Integration” theory is an approach to management based on Rooted theory, which has been successfully applied to the management of large enterprises and research organizations of all kinds. State Grid Corporation of China in the management process of the construction of a new energy system, with a strong innovative, large-scale investment, many participating units, urgent needs and other characteristics of its management capabilities put forward higher requirements. In this paper, a system integration principle based on the Bayesian probabilistic approach and the big data is proposed to realize the engineering application of the theory of “Comprehensive Integration”. By splitting the management system of the new energy system construction, the unit composition of the system can be interpreted to form a complete system and node interaction Bayesian network structure. The algorithm proposed in this paper is implemented in Netica, a commercial statistical analysis software, and its effectiveness is verified, which provides an important theoretical basis for the engineering practice of the theory of “Comprehensive Integration”. Finally, the effectiveness of the Dynamic probabilistic network method was quantitatively verified in a lithium battery pack energy storage management example.

Digital application for drug product potency target evaluation in biopharmaceutical manufacturing.

Biopharmaceutical manufacturing entails a series of highly regulated steps. The manufacturing of safe and efficacious drug product (DP) requires testing of critical quality attributes (CQAs) against specification limits. DP potency concentration, which measures the dosage strength of a particular DP, is a CQA of great interest. In order to minimize the DP potency out-of-specification (OOS) risk, sterile fill finish (SFF) process adjustments may be needed. Varying the potency targets can be one such process adjustment. To facilitate such evaluation, data acquisition and statistical calculations are required. Regularly conducting the OOS risk assessment manually using commercial statistical software can be tedious, error-prone, and impractical, especially when several alternate potency targets are under consideration. In this work, the development of a novel framework for OOS risk assessment and deployment of cloud-based statistical software application to facilitate the risk assessment are presented. This application is intended to streamline the assessment of alternate potency targets for DP in biologics manufacturing. The major aspects of this potency targeting application development are presented in detail. Specifically, data sources, pipeline, application architecture, back-end and front-end development as well as application verification are discussed. Finally, several use cases are presented to highlight the application's utility in biologics manufacturing.

Classifying chemicals into toxicity categories based on LC50 values- Pros and cons

Classifying chemicals into toxicity categories based on LC50 values- Pros and cons

Postoperative injectable opioid use and incidence of surgical site complications after use of liposomal bupivacaine in canine gastrointestinal foreign body surgery.

To compare postoperative analgesic use and postoperative complications between dogs that received liposomal bupivacaine (LB) during surgical gastrointestinal foreign body (GIFB) removal and those that did not. Retrospective study. Two hundred five dogs. Medical records for all dogs with GIFB removal at the Purdue University Veterinary Hospital between May 2017 and August 2021 were searched. Incomplete records and dogs with less than 2 weeks' veterinary follow up were excluded. Data collected included: patient information, time until surgery, intraoperative findings, surgical data (including perforation at time of surgery, linear vs. solid, enterotomy vs. enterectomy), use of LB (including time and manner of administration), time to extubation after surgery, in-hospital postoperative analgesic use and duration, and postoperative complications. Fentanyl was noted as used/not used, quantified as mean hourly rate over 12 h intervals. All analyses were performed using commercial statistical software with p < .05 as the significance level. Dogs that received LB were heavier (n = 65, median 28.5 kg) than those that did not (n = 140, median 24.4 kg) (p = .005). Postoperative fentanyl use (p < .05 between 13 and 72 h) and hourly rates (p < .05 between 13 and 48 h) were less, and postoperative time in the intensive care unit (ICU) (p < .001) and hospital were shorter (p < .001) in dogs receiving LB. Postoperative wound complications were seen in 7/65 dogs (10.8%, 95% CI = 4.4-21.0%) with LB and 4/140 (2.9%, 95% CI = 0.8-7.2%) without LB (p = .039). Use of LB was associated with reduced postoperative analgesic use, and shortened ICU and hospital stay but also with wound complications. Caution should be used when using LB in (clean) contaminated surgeries.

The minimal important difference of six-minute walk test in subjects with chronic pulmonary aspergillosis treated with six-months of oral itraconazole.

The minimal important difference of six-minute walk test in subjects with chronic pulmonary aspergillosis treated with six-months of oral itraconazole.

Evaluation of automated external defibrillator designed for people in dogs.

To determine if human automated external defibrillators (AEDs) could successfully record cardiac electrical activity in dogs, make appropriate recommendations regarding shock delivery, and characterize skin preparation required for a readable ECG based on dog haircoat characteristics. Prospective study of AED use in dogs conducted between January and March 2021. University teaching hospital. Three groups of client-owned dogs were evaluated. Group 1 consisted of 23 healthy dogs with sinus rhythms, group 2 consisted of 9 dogs with documented cardiac arrhythmias, and group 3 consisted of 9 dogs receiving CPR following naturally occurring cardiopulmonary arrest. Haircoat characteristics and clipping or ECG paste required to obtain a readable ECG were recorded. The time interval from a readable ECG by the investigator until AED shock advisement was measured. Correctness of shock advice was recorded. Analyses were performed using commercial statistical software. P-values <0.05 were considered significant. The attending veterinarian judged the ECG on the AED to be readable in all dogs. Time to shock advisement in all dogs was median 18 (range: 7-180) seconds. Dogs with heavy, long, or double haircoats required clipping in 24 of 27 (89%) cases to obtain a readable ECG. ECG paste on the AED pad was required in 36 of 40 dogs (90%) in order to obtain a readable ECG. The AED advice for delivery of shock was appropriate in 51 of 52 (98%) queries of the machine across all groups. Human AEDs can successfully record cardiac electrical activity in dogs. AEDs appropriately recommend delivery of a shock most times, contingent on skin preparation. Dogs with double, long, or heavy haircoats should be clipped prior to pad application. ECG paste will aid AED reading in all haircoat types. Further investigation is warranted into AED use in dogs, particularly in general practices.

Relationship between sexual and bladder dysfunction in women consuming ketamine.

Although ketamine has become the second most popular recreational drug in Taiwan, there have been very few reported studies that investigated female sexual dysfunction (FSD) in ketamine abusers (KAs). We sought to compare the difference between street and hospital KAs and explored the risk factors for FSD and lower urinary tract symptoms (LUTS) in KAs. In this cross-sectional study, female KAs aged 18 years or older were invited to complete anonymous questionnaires during an educational course provided by the departments of substance control and prevention of the local government or under the instruction of medical providers at a urology clinic. Data were reported as median (IQR) and OR and analyzed with commercial statistical software. Key outcome measurements were illicit drug use history, FSD symptoms, and LUTS severity. We included 139 women (104 street and 35 hospital KAs) with a median age of 27.08years. FSD was reported in 76% of all the participants (street vs hospital KAs, 68% vs 97%, P < 0.001). LUTS (Interstitial Cystitis Symptom Index [ICSI] + Interstitial Cystitis Problem Index [ICPI] ≥12) was found to be a significant risk factor for FSD in KAs. More hospital KAs (71%) reported experiencing LUTS (ICSI + ICPI ≥12) than street KAs (8%, P < 0.001). Longer duration of ketamine use (≥36months) and mild to severe psychological symptoms (5-item Brief Symptom Rating Scale [BSRS-5] ≥6) were significant risk factors for LUTS. Sexual problems among KAs should not be overlooked since more severe sexual dysfunction was observed in patients reporting LUTS. To our knowledge, the present study is the largest study using validated and reliable questionnaires to examine FSD in KAs and also the first study to include street KAs. The main limitation of this study is using self-report questionnaires as they are subjective and susceptible to human errors and recall biases. Women who abused ketamine and reported experiencing LUTS were found to be more likely to have FSD.

Tuberculosis in the Russian Federation: Prognosis and Epidemiological Models in a Situation After the COVID-19 Pandemic

AimBecause of the COVID-19 pandemic, many support programs for tuberculosis (TB) patients have been discontinued and TB mass screening activities decreased worldwide, resulting in a decrease in new case detection and an increase in TB deaths (WHO, WHO global lists of high burden countries for TB, multidrug/rifampicin-resistant TB (MDR/RR-TB) and TB/HIV, 2021–2025, 2021). The study aimed to assess changes in epidemiological indicators of tuberculosis in the Russian Federation and to simulate these indicators in the post-COVID-19 period.Materials and MethodsThe main epidemiological indicators of tuberculosis were analyzed with the use of government statistical data for the period from 2009 to 2021. Further mathematical modeling of epidemiological indicators for the coming years was carried out, taking into account the TB screening by chest X-ray. Statistical analysis was carried out using the software environment R (v.3.5.1) for statistical computing and the commercial software Statistical Package for the Social Sciences (SPSS Statistics for Windows, version 24.0, IBM Corp., 2016). Time series forecasting was performed using the programming language for statistical calculations R, version 4.1.2 and the bsts package, version 0.9.8.Study ResultsThe study has found that the mean regression coefficient of a single predictor differs in the model for TB incidence and mortality (0.0098 and 0.0002, respectively). Forecast of overall incidence, the incidence of children and the forecast for mortality using the basic scenario (screening 75–78%) for the period from 2022 to 2026 was characterized by a mean decrease rate of 23.1%, 15.6% and 6.0% per year, respectively. A conservative scenario (screening 47–63%) of overall incidence indicates that the incidence of children and the forecast for mortality will continue to decrease with a mean decrease rate of 23.2%, 15.6% and 6.0% per year, respectively. Comparable data were obtained from the forecast of overall incidence, the incidence of children and the forecast for mortality using the optimistic scenario (screening 82–89%) with a mean decrease rate of 22.9%, 15.4% and 6.0% per year, respectively.ConclusionsIt has been proven that the significance of screening with chest X-ray as a predictor of mortality is minimal. However, TB screening at least 60% of the population (chest X-ray in adults and immunological tests in children) have provided relationship between the TB screening rate and TB mortality rate (TB mortality rate increases with an increase in the population coverage and, conversely, decreases with a decrease in the population coverage).

Tuberculosis prevalence in children in the Northwestern Federal District of Russia before and after COVID-19 pandemic: prognosis and epidemiological models

Aim. To assess changes in the epidemic indicators of tuberculosis infection (TB) in children in the Northwestern Federal District of Russia before and after the COVID-19 pandemic based on mathematical modeling and forecasting.Materials and methods. The main epidemiological indicators of TB were analyzed using the official statistical data for 2009–2021. A mathematical forecasting of epidemiological indicators was performed based on chest X-ray screening for TB. A statistical analysis was carried out using the software environment R (v.3.5.1) and the commercial software Statistical Package for Social Sciences (SPSS Statistics for Windows, version 24.0, IBM Corp., 2016). Time series forecasting was performed using the programming language of statistical calculations R, version 4.1.2 and the bsts package, version 0.9.8. Results. The mean regression coefficient of a single predictor was found to differ in a model for TB morbidity in children is 0.0098. X-ray screening for TB was established to be a significant mortality predictor in children. At least 60% of the population should undergo TB screening in order for TB prevalence to be controlled in a country with a population above 140 million people.Conclusions. The conducted study revealed a positive correlation between the incidence of tuberculosis in children in Russia and TB screening in at least 60% of the population. Under the current TB screening system in Russia, the epidemic TB situation will continue to improve, despite COVID-19 restrictions. At the same time, in the Northwestern Federal District of Russia, preventive TB screening can be considered sufficient only in the Kaliningrad, Murmansk, and Pskov Oblasts.

Tuberculosis in Adults and Children in the Northwestern Federal District: Changes in Epidemiological Rates and Criteria for Their Assessment

The epidemic situation is monitored by numerous rates that may not reflect it objectively which will subsequently lead to higher incidence rates and severe forms of tuberculosis in both adults and children in the regions with the most unfavorable situation.The objective: to evaluate epidemiological rates for tuberculosis in the Northwestern Federal District to identify the most significant, and assess the epidemic situation in the region using these most significant rates.Subjects and Methods. We analyzed the main epidemiological rates of pediatric tuberculosis according to federal statistics (Forms 8 and 33) in 11 districts of the Northwestern District in 2019-2021. Annual figures were obtained from open demographic data of the state statistics (https://www.fedstat.ru). Statistical analysis was pe`rformed using the free software R (v.3.5.1) and the commercial Statistical Package for the Social Sciences (SPSS Statistics for Windows, Version 24.0, IBM Corp., 2016). Hierarchical cluster analysis and k-means clustering were used with the selection of the lowest and highest values of rates. A formula is proposed for calculating the coefficient of full coverage with preventive screening (COP) for tuberculosis of the population which allows adjusting the analyzed epidemic rates taking into account the maximum coverage of the population with preventive screening and determining the accuracy of previous analysis.Results. According to the data obtained, in 2017 and 2018, Vologda Oblast and Nenets Autonomous Okrug were epidemically favorable regions, while in 2020 and 2021 Kaliningrad, Leningrad and Novgorod Oblasts were regarded as favorable regions that were steadily improving their performance. Regions with unfavorable tuberculosis situation include Pskov Oblast, St. Petersburg and the Komi Republic. At the same time, the first two regions occupy this position stably from 2017 to 2021. The use of the coefficient of low coverage with screening for tuberculosis made it possible to determine that Murmansk Oblast, St. Petersburg, Leningrad and Pskov Oblasts in 2020 and 2021 are prognostically unfavorable regions despite a decline in official tuberculosis rates. The data obtained correlate with a high percentage of positive tests with the tuberculosis recombinant tuberculosis allergen (TRA) in children in the regions mentioned above.Conclusions. The analysis of the data clearly demonstrates the possibility of determining the epidemically most favorable or unfavorable regions using four rates: coverage with preventive screening, incidence in the adult population, incidence in children aged 0 to 17 years, and tuberculosis mortality. Cluster analysis using these rates, calculation of rates using the developed coefficient of low coverage with screening for tuberculosis, and analysis of positive results of TRA test in children allows identifying the most epidemically unfavorable regions, despite the decrease in some rates that can be regarded as favorable.

Tuberculosis in the Russian Federation: Dynamics of the Epidemic Indicators before and after COVID-19 Pandemic.

The measures taken against tuberculosis (TB) in recent years in the Russian Federation have been highly effective. Unfortunately, the COVID-19 pandemic may seriously undermine the progress that has been made in the fight against TB. The aim of this study was to assess changes in the epidemiological rates of tuberculosis in the Russian Federation before and after the COVID-19 pandemic. Materials and methods. The analysis was conducted by considering the main epidemiological indicators of tuberculosis, according to the federal statistics for the period from 2017 to 2021. The parameters were estimated according to the data received from 11 areas in the North-Western region. Statistical analysis was carried out using the free software computing environment R (v.3.5.1) and the commercial software package Statistical Package for the Social Sciences (SPSS Statistics for Windows, version 24.0, IBM Corp., 2016). Research results. We found a positive correlation between the incidence among the overall population and the incidence among children aged 0–17, inclusively (r = 0.55 in 2017, r = 0.60 in 2020, and r = 0.53 in 2021). Along with the received regularities, a different trend is shown in the data analysis of general incidence and health X-ray examination for tuberculosis among the general population. The correlation has decreased threefold from 2017 (r = 0.72) to 2020 (r = 0.32); this negative trend might be the result of factors such as the quality of X-ray screening examinations among the general population, and the reduced assessment objectivity of the tuberculosis incidence rate. Conclusions. In assessing the correlation between general incidence and incidence in children under 17 years of age, as well as between incidence and mortality in the Russian Federation, a positive correlation was found with an increasing trend. Such a discrepancy might be due to decreases in the occupational health examination coverage among the general population. Therefore, in the years ahead, we can expect epidemiological indicators to increase incidence and mortality, including child mortality, associated with the insufficient detection of tuberculosis among the population during the COVID-19 pandemic.

​Analysis of Uterine and Systemic Parameters in Fertile and Barren Mares

Background: Breeding success in mares is dependent on both local and systemic factors. Uterine conditions such as endometritis have a negative impact on fertility. Similarly, poor body scores and systemic inflammatory conditions are associated with reduced pregnancy rates. This study aimed to investigate differences in uterine and systemic status between fertile and barren mares. Methods: Uterine ultrasonographic findings, endometrial cytology, body condition score, rectal temperature and complete blood count were evaluated in sexually mature fertile (n=15) and barren (n=15) thoroughbred mares. Differences in the mean values of various parameters between the two groups were evaluated for statistical significance through independent t-tests using commercial statistical software. Result: Compared to fertile mares, barren mares had a significantly higher number of neutrophils and a significantly higher neutrophils: epithelial cell ratio as per endometrial cytology. The ultrasonography revealed presence of uterine fluid in 12 out of the 15 barren mares. Uterine fluid was not observed in any of the fertile mares. No differences in body condition score, rectal temperature and complete blood count were observed between the two groups. These results suggest that infertility in mares results predominantly from alterations in the uterine health.

Depth of Cure, Hardness, Roughness and Filler Dimension of Bulk-Fill Flowable, Conventional Flowable and High-Strength Universal Injectable Composites: An In Vitro Study.

(1) Objective: To evaluate and compare the depth of cure (DOC) of two bulk-fill flowable composites (Filtek Bulk Fill Flowable Restorative and Tetric EvoFlow Bulk Fill), two conventional flowable composites (Filtek Supreme XTE Flowable Restorative and G-ænial Flo X) and one high-strength universal injectable composite (G-ænial Universal Injectable). (2) Methods: specimens were placed in a stainless-steel mold with an orifice of 4 mm in diameter and 10 mm in depth and light-cured for 20 s using a light emitting diode (LED) light-curing unit (LCU) with an irradiance of 1000 mW/cm2; depth of cure was assessed using the ISO 4049 scrape technique, and the absolute length of the specimen of cured composite was measured in millimeters with a digital caliper. The same procedure was repeated with 14 samples for each material under investigation, for a total number of 70 test bodies. Material roughness and hardness results were also investigated using, respectively, a 3D laser confocal microscope (LEXT OLS 4100; Olympus) at ×5 magnification and a Vickers diamond indenter (Vickers microhardness tester, Shimadzu®, Kyoto, Japan) under 10-N load and a 30 s dwell time. SEM images at 3000 and 9000 magnification were collected in order to study the materials’ filler content. Statistical analysis were performed by a commercial statistical software package (SPSS) and data were analyzed using multiple comparison Dunnett’s test. (3) Results: The average DOC of both bulk-fill composites was more than 4 mm, as a range of 3.91 and 4.53 mm with an average value of 4.24 and 4.12 mm, while that of the conventional flowable composites was much lower, as a range of 2.47 and 2.90 mm with an average value of 2.58 and 2.84 mm; DOC of the high-strength injectable composite was greater than the one of traditional composites, but not to the level of bulk-fill materials, as a range of 2.82 and 3.01 mm with an average value of 3.02 mm. Statistical analysis revealed significant differences (p-values < 0.05) in the depth of cure between bulk fill flowable composites and other composites, while there was no difference (p-values > 0.05) between the materials of the same type. (4) Conclusions: Bulk-fill flowable composites showed significantly higher depth of cure values than both traditional flowable composites and high-strength injectable composites.

Research Dominance Definitions May Not Identify Higher Risk Limb for Anterior Cruciate Ligament Injury in NCAA D3 Student-Athletes.

Background/PurposeRecent work has identified non-significant correlations of established limb dominance to the lower extremity (LE) at greater risk for Anterior Cruciate Ligament (ACL) injury in an active, non-athletic sample. The most common LE dominance definition is preferred leg to kick a ball. Athletes develop a unilaterality pattern different from their active, non-athlete peers. Therefore, the purpose of this study was to explore the correlation between the LE used to kick a ball with and the limb identified at greater risk of ACL injury in National Collegiate Athletic Association (NCAA) Division III athletes.DesignAn Observational Descriptive study designMethodsForty-six student-athletes that were active on their NCAA Division III football, field hockey, volleyball, and soccer team rosters were recruited. Upon completing consent, participants performed two tasks (kicking a ball; unilateral land) in a counterbalanced order. Data were entered into and analyzed with a commercial statistical software package where a phi coefficient and Chi-squared analysis were performed.ResultsOf the 46 student athletes who participated (Female=32, Male=14, 19.48±1.26years, 171.75±10.47cm, 77.26±18.74kg), 25 participants kicked and landed with the same limb. Twenty participants chose kicking and landing with different limbs. The Phi Coefficient (Φ= 0.001; P= 0.97) indicated little to no relationship between the LE a participant kicked and landed with. Likewise, the Chi-square statistic revealed no statistical differences between observed and expected frequencies (χ2= 0.001; p= 0.97).Discussion/ConclusionNCAA Division III athletes display a statistical absence of preferred limb predictability utilizing the most common dominance definition (kicking a ball) as it relates to identifying LE at risk of ACL injury. The results suggest that the prevalent LE dominance definition is problematic when exploring ACL injury risk in this population.

Multi Regression Analysis to Suggest Optimum Drilling Weight On Bit and Penetration Rate for Optimum Rate of Penetration Propose Well

R is a system for analyzing statistical data included in open source software group or also called freeware. R software less popular when compared with other paid statistical software such as SPSS, MINITAB, SAS or Eviews. Limited references and support especially in Indonesian, is one of the reasons statistical users prefer commercial statistical packages over free R software and provide results that are no less powerful and interesting graphics systems. Among many statistical techniques that R software can accomplish, one of the most popular is multiple regression analysis. In this article, we will discuss about multiple regression analysis modeling using R software as an alternative software for determining Weight on Bits (WOB) and optimal Rate of Penetration (RPM) in oil and gas drilling. Multi-regression analysis aims to get maximum drilling rate at drilling process, which is reduce drilling time and drilling cost. Bourgoyne and Young ROP models have been chosen to observe effects of several parameters during drilling operations such as drilling depth, pore pressure, equivalent circulation density, bit weight, rotating speed, bit tooth wear and jet collision force were extracted from the final drilling report. Results of the analysis are used to determine the optimum value of the weight of the bit which provides optimal drilling operations and optimized WOB has been calculated for several data points. the results show that R software can be used for multi regression analysis, and and produce a multi-regression equation that can be used to predict the optimum WOB and RPM for further drilling in equivalent rock formations.

Physiological Aspects of Cordillera Weaving in the Philippines

This novel study examined the physiological aspects of weaving among 20 female weavers from the Cordillera Region of Northern Luzon, Philippines. Demographic profile and anthropometric measures were gathered, heart rate (HR) and posture were continuously monitored while the weavers performed a 30-min weaving task. Data were analyzed using mean ± standard deviation and Pearson’s correlation coefficient to identify any relationship. Analysis was conducted using a commercial statistical package (SPSS version 25, IBM, Chicago, IL) with alpha set at 0.05 level. Data revealed that the weavers’ blood pressure is at the prehypertension stage, body fat percentage relative to age is average, BMI value is classified as overweight, and WHR value showed that they are at risk from metabolic disorders. Results also showed that the occupational demands of weaving presented low cardiovascular workload and increased task difficulty resulted to more forward lean among weavers. Additionally, there was a linear relationship between HR and posture. These findings suggest the potential for increased risk for musculoskeletal injuries with weaving.

Y Kuşağı Davranışlarının Kariyer Yönetimi Üzerindeki Etkisi: İstanbul Avrupa Yakasında Golf Sektöründe Bir Araştırma1 (Effect of the Y Generation Behaviours on the Career Management: A Research in the Golf Sector on The European Side of Istanbul)

Purpose – The aim of this study was to determine the effect of the perception of generation Y on career trends. The perception and career tendencies of the next generation was examined for demographical differences such as gender, marital status, age, educational status, faculty, department, duration of professional experience, number of siblings, family income, family residence location, the sector in which the father works, the sector in which the mother works, the sector in which the incumbent wants to work, the city of residence. Design/methodology/approach – A regression analysis was carried out with data obtained by 70 golf coaches who are located on the European side of Istanbul. The relationship between Generation Y Perception and Career Tendency was analyzed by Pearson Correlation test. The effects of Generation Y Perceptions on Career Tendency sub-dimensions were tested by multiple regression analysis. The analyses were carried out with SPSS 25.0 commercial statistical software. Findings – The results of the analysis show that, as the use of technology increases, managerial and competitiveness career tendencies increase. As proactivity increases, the level of independence, managerial, private life, competitiveness and dignity will increase; and when sociability increases, the level of independence, administrative, security/stability, privacy and dignity will increase for generation Y. Discussion – Enterprises should provide support to training development activities for Generation Y employees to participate in new projects that will increase their creativity, to participate in decisions by taking the initiative, to reveal or increase their creativity with on-the-job and off-the-job training methods; It should develop strategies to retain and attract personnel and then in line with the human resources management policies in line with the demands of Generation Y in order to employ them for a long time.

Abstract P216: Speed-Accuracy Tradeoffs During Cognitive and Upper-Limb Horizontal Movement Tasks in Chronic Strokes

Objectives: This study investigated cognitive-motor interference on the relationship of speed and accuracy during a cognitive and upper-limb motor dual task. Method: Nine stroke patients (56.5±7.3 years; M:9) participated in a series of cognitive-motor dual tasks. A subject with chronic stroke was seated with paretic hand fastened on the handle and then one of five motor tasks was provided (Figure 1A). Visual feedback in a front screen was synchronized as the handle cursor moves within the movement trajectory with two difficulty levels (5cm or 10cm). In a dual task, a cognitive task, Serial Seven(S7), was concurrently provided with a randomly chosen number at the onset of the motor task by a test administrator.Figure 1 Cognitive-Motor dual task setup (left up) and trajectory shapes (Diagonoal; Mediolateral; Anteroposterior; Cross; Circle) and level of difficulties (Easy 10cm or Hard 5cm) in motor tasks. The motor speed and accuracy and the cognitive speed and accuracy were evaluated during one-minute trial time. Pearson-correlation coefficients evaluated outcome relationship of the speed and accuracy in single or cognitive-motor dual tasks with the significance level 0.05 using a commercial statistics package (SPSS ver 22, Chicago IL,US). Results: There were significant positive correlation between single and dual motor speeds ( Easy :R 2 =0.678,p&lt;0.001; Hard : R 2 =0.714,p&lt;0.001) and significant negative correlationbetween single motor speed and dual cognitive speed ( Easy : R 2 =0.661,p&lt;0.001; Hard :R 2 =0.6523,p&lt;0.001) (Figure 1B) Conclusions: There were significant correlations between the upper-limb horizontal movements with visual feedback and S7 cognitive task. This study may provide useful information on upper-limb motor robotic therapies using 2D horizontal upper-limb movements.