Although current commercial acrylic bone cements have been used successfully in total joint replacement surgery for over five decades, some further improvement are being investigated to cope with cement failure, one approach is surface modification of BaSO4 particles to improve its interfacial adhesion with the polymeric matrix in acrylic bone cements formulations. In this article, BaSO4 particles were modified by different surface treatments. The first of them involved the use of 3-(trimethoxysilyl)propyl methacrylate as a coupling agent; in the second, the radiopaque particles were exposed to oxygen plasma at power levels of 15 and 70 W, followed by MPS coupling agent and the last one consisted in exposing the radiopaque particles to methyl methacrylate (MMA) plasma. Mechanical properties of the bone cements prepared with modified BaSO4 particles were improved due to its higher dispersion degree in polymeric matrix.