Heat-moisture comfort of the fabric is an important part to judge its performance. The research of heat-moisture is a frontier topic in the field of modern textile technology, increasingly brought to the attention of the national textile field researchers and become a hot issue worldwide.This topic research personnel, in the use of multiple regression analysis method to establish the fabric heat transfer law of mathematical model, using the method of unified goal of thermal and moisture comfortable building fabric performance comprehensive evaluation system, based on the thermal wet comfort properties of fabrics parameters optimization research. In establishing the evaluation system of fabric heat-moisture comfort performance, mathematical knowledge-based on Matlab software is a tool to solve practical problems. Heat-moisture transfer fabric and strive to build a mathematical model of the law, as well as comprehensive evaluation system of heat-moisture comfort performance, providing an important reference for technical textile enterprises to develop new products, enhance and improve the performance of the heat and moisture comfort of fabric.