Combined Nearly Ideal Binary Solvent Research Articles

Comment on “Solid-Liquid Phase Equilibrium and Thermodynamic Properties of Olaparib in Selected Organic Solvents and (Tetrahydrofuran + MTBE, Acetonitrile + Isopropyl Alcohol) Binary Solvent Mixtures”

Several mathematical errors in the published paper by Zhao and co-workers are identified. The errors pertain to the calculated equation coefficients for the polynomial version of the combined nearly ideal binary solvent (CNIBS)/Redich-Kister and for the Combined Jouyban–Acree–van’t Hoff equation. In the case of the CNIBS/Redlich–Kister equation the authors’ tabulated equation coefficients give 100 times the mole fraction solubility of olaparib, and not the mole fraction solubility as the authors’ equation implies.

The Solubility of the Oil Scale Inhibitor Amino Trimethylene Phosphonic Acid in Different Binary Solvents

Amino trimethylene phosphonic acid (ATMP) is a common scale inhibitor using in oil field that always combines with a variety of surfactants and auxiliaries. It is necessary to know its solubility for purifying and combining. With a laser monitoring observation technique, the solubility of amino ATMP in binary solvent mixtures were measured by using the isothermal method from 298.15 to 343.15 K. Results of these measurements were correlated by the combined nearly ideal binary solvent (CNIBS)/Redlich-Kister equation. For these data studied, the CNIBS/Redlich-Kister equation was found to provide an accurate mathematical representation of the experimental data.

Solubility, Density and Solution Thermodynamics of NaI in Different Pure Solvents and Binary Mixtures

Solubility of NaI in water, methanol, ethanol, propan-2-ol, and also in water + methanol, water + ethanol, and water + propan-2-ol binary mixtures have been experimentally measured using a gravimetric method at temperatures (298.15.303.15, 308.15, and 313.15) K. The combined NIBS (nearly ideal binary solvent)–Redlic–Kister equation is used to fit experimental solubility data at constant temperature. The densities of the saturated solutions are also reported in pure and binary solvent mixtures at temperatures mentioned above. Thermodynamic functions including ΔHsoln0, ΔGsoln0, and ΔSsoln0 of solution of NaI are obtained from the modified van’t Hoff equation. A comparison of the relative contributions by enthalpy (ζH) and entropy (ζTS) is made which indicated that the main contributor to the positive standard molar Gibbs energy of solution of NaI is the entropy for solution of NaI in water + methanol having xC0 < 0.5 and for all other solutions it is enthalpy.

Solubility of l-phenylalanine in water and different binary mixtures from 288.15 to 318.15 K

The solubility of l-phenylalanine in water and binary mixtures (methanol+water and ethanol+water) at temperatures ranging from 288.15 to 318.15K was investigated. The results obtained from these measurements were correlated with the temperature and the molar fraction of water by the combined nearly ideal binary solvent (CNIBS)/Redlich–Kister(R–K) model and the semiempirical Apelblat model. Both of the models demonstrated good fitting with the experimental data, while the CNIBS/R–K model gave a more accurate prediction. In addition, the thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy, were obtained using the van’t Hoff equation and the Gibbs equation. The experimental results showed that water was a better solvent for l-phenylalanine than methanol and ethanol, which could thus be used as effective anti-solvents in the crystallization process. For all the cases studied, the values of both the standard molar enthalpy change and standard molar Gibbs energy change of solution were positive, which indicated that the process was endothermic and not spontaneous.

Effect of pH, temperature and solvent mole ratio on solubility of disodium 5′-guanylate in water + ethanol system

Solubility of disodium 5′-guanylate in water + ethanol binary solvent mixtures was determined by a gravimetric method in the temperature range from 283.15 K to 323.15 K, pH range from 8 to 10 and at different water/ethanol mole ratios. The effects of pH, temperature and water/ethanol mole ratio on the solubility were investigated in detail. The modified Apelblat model and the combined nearly ideal binary solvent (CNIBS)/Redlich–Kister model were selected to correlate the experimental data. The results showed that the experimental data was satisfactorily correlated by the (CNIBS)/Redlich–Kister model, but for the modified Apelblat model, the correlation was not so satisfactory in some cases.

Solubility of Tobramycin in Binary Water−Ethanol Solvent

The solubility of tobramycin in binary ethanol + water solvent mixtures has been measured using the static analytical method over an experimental temperature range of (288.2 to 328.2) K. The experimental solubilities were correlated with the combined nearly ideal binary solvent (CNIBS)/Redlich−Kister equation which provided an accurate mathematical representation of the experimental data.

Solubility of 1-Hydroxyethane-1,1-diphosphonic Acid Monohydrate in Aqueous Acetic Acid Mixtures

The solubility of 1-hydroxyethane-1,1-diphosphonic acid (HEDP) monohydrate (A) in binary acetic acid (B) + water (C) solvent mixtures was measured by using the isothermal method from (293.15 to 328.15) K. A laser monitoring observation technique was employed to determine the dissolution of the solid phase in a solid + liquid mixture. The solubility data were correlated by the combined nearly ideal binary solvent (CNIBS)/Redlich−Kister equation.

Solubility of Clindamycin Phosphate in Binary Water−Ethanol Solvent

The solubilities of clindamycin phosphate in different solvents were measured using a static method. The RP-HPLC was used to determine the concentration of clindamycin phosphate in the liquid phase. The solubility data were correlated with the combined nearly ideal binary solvent (CNIBS)/Redlich−Kister equation which provided an accurate mathematical representation of the experimental data.

Solubility of piperonal in different pure solvents and binary isopropanol+water solvent mixtures

Using a laser monitoring observation technique, the solubilities of piperonal in different pure solvents and binary isopropanol+water solvent mixtures were determined by synthetic method from 273.15 K to 293.15 K. Results of these measurements were correlated by Apelbat equation and the combined nearly ideal binary solvent (CNIBS)/Redlich-Kister equation. The results find that Apelbat equation and the combined ideal binary solvent (CNIBS)/Redlich-Kister equation provided accurate mathematical representations of the experimental data, respectively.

Solubiliy of Sodium Cefotaxime in Aqueous 2-Propanol Mixtures

Using a laser monitoring observation technique, the solubilities of sodium cefotaxime (A) in binary water (B) + 2-propanol (C) solvent mixtures were determined by the synthetic method from 278.15 K to 308.15 K and in the solvent composition ( ) range from 0.025 to 1.000. The results of these measurements were correlated by the combined nearly ideal binary solvent (CNIBS)/Redlich−Kister equation. For the seven mixtures studied, the CNIBS/Redlich−Kister equation was found to provide a good correlation of the experimental data.

Solubility of Cefazolin Sodium Pentahydrate in Aqueous 2-Propanol Mixtures

Using a laser monitoring observation technique, the solubilities of cefazolin sodium pentahydrate in binary 2-propanol + water solvent mixtures were determined by the synthetic method from 273.15 K to 308.15 K. The results of these measurements were correlated by the combined nearly ideal binary solvent (CNIBS)/Redlich−Kister equation. For the eight group data studied, the combined ideal binary solvent (CNIBS)/Redlich−Kister equation was found to provide an accurate mathematical representation of the experimental data.

Solubility of dl-p-hydroxyphenylglycine Sulfate in Binary Acetone + Water Solvent Mixtures

By use of a laser monitoring observation technique, the solubilities of dl-p-hydroxyphenylglycine (dl-p-HPG) sulfate in binary acetone + water solvent mixtures were determined by the synthetic method from 303.15 K to 323.00 K, respectively. Results of these measurements were correlated by the combined nearly ideal binary solvent (CNIBS)/Redlich−Kister equation. For the five group data studied, the combined ideal binary solvent (CNIBS)/Redlich−Kister equation was found to provide an accurate mathematical representation of the experimental data.