Patients need an effective treatment to combat the harm painful peripheral neuropathy (PPN) inflicts on them. Experts describe our current treatments as “inadequate,” “frustrating and maybe even appalling” while claiming that “nerves in patients with neuropathy are irreversibly damaged.” Thus, Regenerating nerves, Reducing pain, and Restoring function without side effects defines a truly effective treatment. Odell and Sorgnard brilliantly developed CET (Combined Electrochemical Treatment) to effectively treat neuropathy. A retrospective outpatient study using CET on six patients with PPN did not require Institutional Review Board approval, but did receive consent from each of the treated patients. Epidermal Nerve Fiber Density (ENFD) biopsies were done before and after treatment. The highest pain scores and functioning indexes were recorded during the treatment, at the end of treatment and when last seen. Changes in medication use and side effects were recorded. Five of six patients were followed for an average of 26 months after ending treatment and one lost to follow-up. On average, five of six (83%) had a 91% increase in their nerve fibers. The average patient reduced their pain 75% at the end of treatment and 81% when last seen, while improving their function by 60% at the end of treatment and 65% when last seen. Four of five patients on medication for PPN stopped one or more of these. None had side effects. These results prove that CET, which can easily be used in any office that treats neuropathy, meets the definition of an effective treatment for PPN.