The working principle of the combined cycle in the combined cycle power plant (CCPP) is to utilize a certain amount of waste heat in the gas turbine, which reaches temperatures of 1650°C, to generate steam in the steam turbine. Due to the high temperature of the exhaust gas in the gas turbine, a device is needed to recover this waste heat, known as a Heat Recovery Steam Generator (HRSG). Compared to conventional HRSG, a once-through heat recovery steam generator (OTHRSG) offers the advantages of faster design time (25% faster than conventional) and lower design costs because it does not require a drum which contributes to an increase in thermal efficiency. This study aims to model and simulate the CCPP system with an OTHRSG to achieve maximum thermal efficiency by using biogas from the degradation of organic waste as the input fuel for CCPP using Cycle Tempo software. The thermal efficiency of the CCPP system was achieved at 57% by applying turbine inlet temperature (TIT) of 1500°C and compression ratio of 46. These results proved that the CCPP system by using biogas as fuel could increase the thermal efficiency of a single cycle power plant.