Background. Combined surgical treatment in patients with refractory glaucoma and cataract allows achieving stable compensation of intraocular pressure and a significant improvement in visual functions. Purpose. To study some aspects of efficacy and safety of combined endoscopic cyclophotocoagulation (ECP) with cataract phacoemulsification. Methods. 78 patients with uncompensated open-angle glaucoma at various stages were enrolled. They were treated with ECP and phacoemulsification. Among them there were 40 (51.28 %) men and 38 (48.72 %) women. The follow-up period was from 6 to 48 months. Mean age of the patients was 73.46 years. Results. At the end of the follow-up period, there was a significant decrease in mean IOP to 18.2±1.5 mm Hg, in comparison with the initial level of 24.1± 3.2 mm Hg (p<0.0001). At the same time, complete success was achieved in 46.6 % (34 eyes); qualified success (reduction of IOP to 21 mmHg and below) was achieved in 51.3 % (40 eyes). The number of topical glaucoma drugs has also significantly decreased from 2.5±1.0 to 1.9±1.0 (p = 0.001). Conclusion. ECP can be considered as a safe and effective antiglaucoma component of combined glaucoma and cataract surgery. Key words: glaucoma; transscleral laser cyclodestruction; endoscopic cyclophotocoagulation; microinvasive glaucoma surgery.