The pig farm wastewater after anaerobic digestion has attracted much attention due to its difficulty to be biochemically treated. This paper evaluated the potential of the combined anaerobic-aerobic process to treat digested wastewater from synthetic pig farms in terms of nitrogen, phosphorus, and organic compound removal. The experimental results showed that despite the low COD/TN(C/N) ratio of digested wastewater from pig farms, the removal efficiency of ammonium, total phosphorus (TP), and organic compound could reach 100%, 85%, and 87% respectively after reaching a steady-state by the combined anaerobic-aerobic process with an average hydraulic retention time of 3 days. The Anammox and Algae-Bacteria Symbiosis (An-ABS) system was significantly more effective than the Algae-Bacteria Symbiosis (ABS) system for nitrogen and phosphorus removal. When anaerobic ammonia-oxidizing granular sludge was introduced, the sedimentation performance of the algae-bacterial synergistic symbiotic system was significantly improved. The addition of anaerobic ammonia-oxidized granular sludge not only reduced the sludge diversity but also changed the sludge community structure. In addition, the suspended growth of Chlorella vulgaris protected ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB) from Optical damage. This study would provide some new insights into the combined anaerobic-aerobic process system for treating digested wastewater from synthetic pig farms, which would contribute to the development of low-energy wastewater treatment processes. Data availabilityAll data generated and/or analyzed during this study are included in this published article and its supplementary files.