Tuberculosis is the disease required long term treatment. Rifampicin is the majorelement of antiTB therapy if resistance is not documented. Potential of antitubercular dugsto produced hepatoxicity is very high and among all antiTB agents rifampicin (RIF) inducedhepatoxicity stands on top. Rifampicin is the major element of antiTB therapy if resistance is notdocumented. But its hepatotoxic effects are the main hurdle to continue with this therapy. In thisstudy RIF were administered to the rabbit alone or in combination of propranolol to evaluate thehepatotoxic effects of RIF and reduction of hepatotoxicity by propranolol. Histological evaluationof liver tissue on higher magnification, its micrometric analysis and SEM (scanning electronmicroscopy) of liver were used to estimate the effects of this combination. Micrometry revealedthat number of viable hepatocytes, their diameter and nuclear diameter were altered. SEMmicrograph showed distorted and swollen hepatic cords. All of these changes successfullyturned to normal by combined administration of propranolol. Propranolol successfully improvesthe hepatic architecture proved by both qualitative and quantitative microscopy.