Combination Of Various Strategies Research Articles

Strategic management of intellectual property for technology as an object of civil law relations

Strategic management of intellectual property for technology as an object of civil law relations

Analisa SWOT dalam Bisnis Pariwisata Tour Travel “Eagle Tour and Travel“

Alongside the growth of the tourism industry, especially in the city of Batu, tour & travel businesses such as Eagle Tour & Travel play a crucial role in providing comprehensive and organized travel services for tourists. However, despite having good prospects, businesses like Eagle Tour & Travel still face various operational and marketing challenges. This research is developed to elaborate on the strengths, weaknesses, opportunities, and threats (SWOT) related to the Eagle Tour and Travel business established since 2015. This study aims to conduct a SWOT analysis of the tour and travel tourism business, focusing on the Eagle Tour and Travel brand in Batu City, East Java. Using a qualitative descriptive approach and SWOT analysis method focused on obtaining effective promotional and sales enhancement strategies based on recommendations following external environmental indicators (External Factor Analysis Strategy), then strengths and weaknesses are obtained through internal factors IFAS (Internal Factor Analysis Strategy). The results of the study enable business practitioners to take strategic steps that align with the quadrants of the SWOT Analysis. The combination of various strategies above will assist Tour Travel companies in enhancing competitiveness, facing challenges, and winning the competition in the tourism industry

Transport Demand Management Strategy Priority Assessment Based on Expert Judgment

The main problem of transportation is the very high growth of vehicles causing congestion, resulting in various derivative impacts such as pollution, fuel waste, time value, and other environmental problems. This problem can be solved by Transportation Demand Management (TDM). TDM is a combination of various strategies, which strategy should be chosen whose priority depends on the conditions of each region. This research was conducted in a medium-scale city by determining the priority of TDM using the Analytical Hierarchy Process (AHP) tool. The final result of the judgment is the priority weight of the TDM strategy that will be applied with a CR value of < 10%, namely the pull strategy. This strategy is represented by improving public transport services and infrastructure (especially the integration of public transport services). This study shows that the strategy group with a high AHP Consensus Index (ACI) score means a high consensus among experts.

Research on Localization Status and Investment Strategy of Quantitative Fund in China

In this paper, Quant funds in China based on the market as a starting point for research, at the current mainstream of modern portfolio theory, the factor model and the theoretical basis of dynamic DEA, mainly analyze the modern portfolio theory in the application of funds of funds, not a single security analysis, especially since 2014, when the domestic market emerged a lot of “FOF "and ”FOHF." Most of these portfolio funds do not carry out in-depth analysis of the underlying funds or even understand the trading methods and essence of various strategies, but focus on the combination of various strategies of hedge funds. In this paper, combined with their own learning experiences, the analysis of the various domestic trading strategies, combined with the quantitative funds in China, local firm performance, and portfolio of related theory, the study of portfolio theory in the domestic application of portfolio management, and the practice of funds allow us to put forward some useful suggestions and thinking.

A Model to Manage the Lane-Changing Conflict for Automated Vehicles Based on Game Theory

In this study, we propose a lane-changing conflict management model based on game theory for automated vehicles. When a vehicle plans to change to the adjacent lane, and if there is a closely following vehicle on that lane, the following vehicle must sacrifice its speed to make space for the lane-changing vehicle, which means there are conflicts of interest between two vehicles. So far, there is no clear answer if the following vehicle should make space for the lane-changing vehicle. These individualistic lane-changing models may lead to suboptimal traffic flow or even traffic safety issues. To solve this problem, this study designed a model based on game theory to solve lane-changing conflicts between the lane-changing vehicle and the following vehicle in the target lane. When the two vehicles enter a lane-changing conflict, the payoffs of the two vehicles under various combinations of strategies were evaluated, and the final strategy and the acceleration for each vehicle were obtained based on the principle of benefit equilibrium. The simulation is conducted to analyze the game strategy of the lane-changing vehicle (LV) and the close rear vehicle (RV) in the process of lane-changing from different initial positions. The results show that, under the hypothesis scenario in the simulation, the strategy {changing a lane, avoiding } will be chosen when the RV is initially located in the range of [0, 40 m], while {not changing a lane, not avoiding} is more appropriate when the initial position of the RV is in the range of [41 m, 90 m].

Overcoming barriers in non-viral gene delivery for neurological applications.

Gene therapy for neurological disorders has attracted significant interest as a way to reverse or stop various disease pathologies. Typical gene therapies involving the central and peripheral nervous system make use of adeno-associated viral vectors whose questionable safety and limitations in manufacturing has given rise to extensive research into non-viral vectors. While early research studies have demonstrated limited efficacy with these non-viral vectors, investigation into various vector materials and functionalization methods has provided insight into ways to optimize these non-viral vectors to improve desired characteristics such as improved blood-brain barrier transcytosis, improved perfusion in brain region, enhanced cellular uptake and endosomal escape in neural cells, and nuclear transport of genetic material post- intracellular delivery. Using a combination of various strategies to enhance non-viral vectors, research groups have designed multi-functional vectors that have been successfully used in a variety of pre-clinical applications for the treatment of Parkinson's disease, brain cancers, and cellular reprogramming for neuron replacement. While more work is needed in the design of these multi-functional non-viral vectors for neural applications, much of the groundwork has been done and is reviewed here.

НЕРЕГУЛЯРНАЯ ДИНАМИКА В АГЕНТ-ОРИЕНТИРОВАННОЙ МОДЕЛИ МИГРАЦИИ

The article is devoted to modeling the dynamics of migration at the regional level. In the context of the transition to a post-industrial society, population migration becomes more dynamic, which requires improving approaches to its forecasting and makes significant the study of personal strategies for choosing the time of migration and the host region by agents. Different strategies of agents lead to the emergence of migrant strata with dynamically changing number, unevenly distributed among the receiving regions. As a result, it can observed nonlinear fluctuations in the number of migrants, for the study of which simulation modeling tools are relevant. This research is devoted to the study of the migration processes complex dynamics by the method of agent-based modeling. The simulation is based on the assumption that a migrant, when choosing a region, follows a strategy, characteristic of his age group, which in the long end directly affects the distribution of the number of migrants of various cohorts and the total number of migrants in the region. At this, the strategy choice is determined by socio-economic characteristics of the regions: different levels of economic, social and environmental attractiveness. The authors hypothesized that different strategies of migration behavior can lead to complex migration dynamics. To test the hypothesis, the authors built a basic agent-based model of migration for three regions, which takes into account various strategies of agents' migration behavior, including the choice of a region with the highest economic, social or environmental level of attractiveness. The result of numerical experiments shows that a combination of various strategies for choosing a region with a change in the age structure of migrants leads to periodic and complex regimes of migration dynamics. The authors have found the conditions under which complex dynamics in the model occurs in the short - and medium-term periods.

Mn-In-Cu co-doping to optimize thermoelectric properties of SnTe-based materials

Lead-free chalcogenide SnTe has a similar crystal structure and energy band structure to high performance thermoelectric material PbTe, which has been widely concerned in recent years. However, due to its low Seebeck coefficient, high intrinsic Sn vacancy concentration and high thermal conductivity, its intrinsic thermoelectric performance is poor. In this study, Mn-In-Cu co-doping SnTe-based thermoelectric materials are prepared by hot pressing sintering at high-temperature and high-pressure. Indium (In) doping brings the resonant level in SnTe and increases the density of states which greatly improves Seebeck coefficient at room temperature; the Seebeck coefficient of Sn<sub>1.04</sub>In<sub>0.01</sub>Te(Cu<sub>2</sub>Te)<sub>0.05</sub> reaches 70 μV·K<sup>–1</sup> at room temperature. With adding manganese (Mn), the Seebeck coefficient at room temperature is well preserved, indicating that Mn doping has little effect on the resonant level brought by In doping. In addition, due to the band convergence brought by Mn doping, the high temperature Seebeck coefficient of the material is improved, the maximum Seebeck coefficient reaches 215 μV·K<sup>–1</sup> for the sample with 17% Mn doping amount at 873 K. Owing to the combination of band convergence and resonant level, the Seebeck coefficient of the whole temperature range of the material increases, the power factor of the material is also greatly optimized, and all samples have a power factor of more than 1.0 mW·m<sup>–1</sup>·K<sup>–2</sup> at room temperature. On the other hand, the point defects brought by Mn alloying and the interstitial defects introduced by copper (Cu) enhance the phonon scattering and effectively reduce the lattice thermal conductivity of the material, the lattice thermal conductivity decreases to 0.68 W·m<sup>–1</sup>·K<sup>–1</sup> at 873 K. The electrical and thermal properties of the materials are optimized simultaneously under the combination of various strategies, the peak <i>zT ≈ </i>1.45 is obtained at 873 K in the p-type Sn<sub>0.89</sub>Mn<sub>0.15</sub>In<sub>0.01</sub>Te(Cu<sub>2</sub>Te)<sub>0.05</sub> sample and the average <i>zT</i> of 300–873 K reaches 0.76. In the process of multi-strategy coordinated regulation of SnTe-based thermoelectric materials, the excellent properties of single strategy can be well maintained, which provides a possibility for further improving the performance of SnTe-based thermoelectric materials.

Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities.

Bioengineering of the human auricle remains a significant challenge, where the complex and unique shape, the generation of high-quality neocartilage, and shape preservation are key factors. Future regenerative medicine–based approaches for auricular cartilage reconstruction will benefit from a smart combination of various strategies. Our approach to fabrication of an ear-shaped construct uses hybrid bioprinting techniques, a recently identified progenitor cell population, previously validated biomaterials, and a smart scaffold design. Specifically, we generated a 3D-printed polycaprolactone (PCL) scaffold via fused deposition modeling, photocrosslinked a human auricular cartilage progenitor cell–laden gelatin methacryloyl (gelMA) hydrogel within the scaffold, and cultured the bioengineered structure in vitro in chondrogenic media for 30 days. Our results show that the fabrication process maintains the viability and chondrogenic phenotype of the cells, that the compressive properties of the combined PCL and gelMA hybrid auricular constructs are similar to native auricular cartilage, and that biofabricated hybrid auricular structures exhibit excellent shape fidelity compared with the 3D digital model along with deposition of cartilage-like matrix in both peripheral and central areas of the auricular structure. Our strategy affords an anatomically enhanced auricular structure with appropriate mechanical properties, ensures adequate preservation of the auricular shape during a dynamic in vitro culture period, and enables chondrogenically potent progenitor cells to produce abundant cartilage-like matrix throughout the auricular construct. The combination of smart scaffold design with 3D bioprinting and cartilage progenitor cells holds promise for the development of clinically translatable regenerative medicine strategies for auricular reconstruction.

Asperbutenolide A, an unusual aromatic butenolide dimer with diverse bioactivities from a marine-derived fungus Aspergillus terreus SCAU011

Two new aromatic butenolides (1 and 2), along with a known analogue (3), were isolated and structurally identified from the fermentation extract of a mangrove sediment derived fungus Aspergillus terreus SCAU011. Structures of the new compounds were established mainly by spectroscopic data analyses, and the absolute configurations were determined by a combination of various strategies including electronic circular dichroism (ECD) comparison, induced circular dichroism (ICD) experiments and chemical derivation and degradation. Compound 2, with an unusual dimeric scaffold linked via an ether bridge, exhibited a wide range of biological properties including strong cyclooxygenase-2 (COX-2) and α-glucosidase inhibitory activities, as well as moderate antiradical and antibacterial effects.

Using Bee Products for the Prevention and Treatment of Oral Mucositis Induced by Cancer Treatment.

Oral mucositis is one of the most frequent complications after chemotherapy or radiotherapy or a combination of both. There is no standard therapy for its prevention or treatment. Considering that some bee products have been found to be of value in this situation, we decided to analyze the scientific literature on the subject. Scientific publications on bee products were identified by a literature search on Pubmed, Scopus and Google Scholar. There is a lot of evidence regarding the use of honey for oral mucositis due to chemotherapy or radiotherapy or a combination of both. Unfortunately, the quality of several meta-analyses on the topic is very low. There is some evidence on propolis, a little on royal jelly and none whatsoever on pollen and other bee products like apilarnil or bee venom. Bee products such as honey, propolis and royal jelly may be well suited to be integrated into a general concept for the prevention and treatment of oral mucositis which should also include other established concepts like oral care, oral cryotherapy, topical vitamin E and low-level-laser therapy. Bee products could become an integral part in the treatment of chemotherapy, radiotherapy and radio chemotherapy. High-quality meta-analyses and further studies, especially on the combinations of various strategies, are needed.

Conservative treatment for well-differentiated endometrial cancer: when and why it should be considered in young women.

The aim of this review was to update current knowledge on the conservative treatment of endometrial cancer (EC) based on a literature review. A web-based search in the MEDLINE database was carried out on EC management and treatment. All relevant information has been collected and analysed. Case series were mainly found in the literature search. Conservative treatments were offered to young patients with stage I low-grade endometrioid carcinomas of the endometrium. Different options included high/low dose progestin treatments, hysteroscopic resection of the disease, a levonorgestrel intrauterine device or a combination of various strategies. The overall complete response rate was near 76.5% with a recurrence rate of up to 33.8%. Pregnancy outcomes reached rates of 64.8% for live births. The current clinical outcomes show that conservative treatment aimed at preserving fertility is feasible for stage I endometrial well-differentiated adenocarcinomas in motivated patients under close monitoring.

Mitigation and Resilience Tradeoffs for Electricity Outages

Large-scale electricity outages have the potential to result in substantial business interruption losses. These losses can be reduced through a number of tactics within the broader strategies of mitigation and resilience. This paper presents a methodology for analyzing the tradeoffs between mitigation and three categories of resilience. We derive optimality conditions for various combinations of strategies for a Cobb-Douglas damage function and then explore implications of a less restrictive Constant Elasticity of Substitution damage function. We also calibrate the model and perform Monte Carlo simulations to test the sensitivity of the results with respect to changes in major parameters. Simulation results highlight the possibility that substitution away from mitigation towards resilience may lower total expected costs from large-scale outages for a given level of risk reduction expenditure when the marginal benefit of resilience is high relative to the expected marginal benefit of mitigation.

Strategies to improve publication activities of the universities participating in Project 5-100

In the recent five years, Russian universities’ publishing activities have increased several times. The authors consider their strategies used to increase publications to be indexed in Scopus database, i. e. publications in foreign journals and conference proceedings, inviting outer authors, so called ‘predatory’ journals. The efficiency of these strategies and their side-effects differ a lot. The universities, intentionally or unwittingly, apply various combinations of strategies based on their intrinsic conditions (administrative practices) and environment (possibility of cooperation). The authors argue that interaction with FASO/RAS institutions is the key driver for several leading Russian universities.

STRATEGIES FOR MANAGING DRUGS AND SUBSTANCE ABUSE AMONG SECONDARY SCHOOL STUDENTS IN KENYA: A CASE OF ELDORET TOWN

Managing of drugs and substance abuse among students in secondary school is vital as one of the national goals of education in Kenya is to provide for the development of knowledge, skills and attitudes that will enhance acquisition of sound moral values and help children grow-up into self-disciplined, self-reliant and integrated citizens. The study assessed the strategies being used to manage drugs and substance abuse among students in secondary schools within Eldoret town and its environs. The study identified the types of drugs and substances commonly abused, the reasons and effects for abuse and the effectiveness of the strategies being used to manage the menace. The study was guided by the Social cognitive learning theory by Albert Bandura, which states that behavior is determined by the environment and a person’s thought processes and pattern of actions. The study utilized descriptive research design. The study adopted both probability and non-probability sampling techniques to determine sample size. The target population of the study comprised of principals, guidance counseling masters and teachers of Christian religious education. Stratified sampling technique was applied to get eight different schools from the area of study; purposive sampling was used to select eight Principals, eight teachers of Guidance and counseling and sixteen teachers of Christian Religious Education while two hundred and twenty form four students were randomly selected to participate in the study. Quantitative Data was collected by use of questionnaires, while interview schedules were employed for qualitative data. Descriptive statistics was utilized to analyze quantitative data; while qualitative data was classified into themes based on the objectives of the study. The results indicated that all the strategies used to manage drugs and substance abuse in secondary schools are effective to some degree and that a combination of various strategies is what is required to have a positive impact. There is need for all stakeholders to consistently review, support and apply different strategies to reduce drugs and substance abuse among the students in secondary schools in Kenya. Article visualizations:

Characteristics of improved formative assessment practice

ABSTRACTAn earlier study showed that the changes in teachers’ classroom practice, after participation in a professional development program in formative assessment, significantly improved student achievement in mathematics. The teachers in that study were a random selection of Year 4 teachers in a Swedish mid-sized municipality. In the present study, we analyse and describe the characteristics of these changes in classroom practice, which were based on a combination of various strategies for formative assessment. Data were collected through teacher interviews and classroom observations. The teachers implemented many new activities that strengthened a formative classroom practice based on identifying student learning needs and modifying the teaching and learning accordingly. The characteristics of the changes the teachers made reveal the complexity of this formative assessment practice and why such developments of practice are likely to require major changes in most teachers’ practices. We also discuss how such changes in practice afford new learning opportunities.

Stromal cell-derived factor-1-directed bone marrow mesenchymal stem cell migration in response to inflammatory and/or hypoxic stimuli

ABSTRACTDirecting cell trafficking toward a target site of interest is critical for advancing stem cell therapy in clinical theranostic applications. In this study, we investigated the effects of inflammatory and/or hypoxic stimuli on the migration of bone marrow mesenchymal stem cells (BMMSCs) during in vitro culture and after in vivo implantation. Using tablet scratch experiments and observations from a transwell system, we found that both inflammatory and hypoxic stimuli significantly enhanced cell migration. However, the combination of inflammatory and hypoxic stimuli did not result in a synergistic effect. The presence of stromal cell-derived factor-1 (SDF-1) significantly enhanced cell migration irrespective of the incubation conditions, and these positive effects could be blocked by treatment with AMD3100. Based on a time course experiment, we found that preconditioning cells with either inflammatory or hypoxic stimuli for 24 h or with both stimuli for 12 h led to high levels of chemokine receptor type 4 (CXCR4) expression. In vivo studies further demonstrated that pretreatment of BMMSCs with inflammatory and/or hypoxic stimuli resulted in an increased number of systemically injected cells migrating toward skin injuries, and local SDF-1 administration significantly increased cell migration. These findings suggest that in vitro control of either inflammatory or hypoxic stimuli has significant potential to enhance SDF-1-directed BMMSC migration via the upregulation of CXCR4 expression. Although combining the stimuli did not necessarily lead to a synergistic effect, the potential to reduce the dose and time required for cell preconditioning indicates that combinations of various strategies warrant further exploration.

Advancements in in vitro hepatic models: application for drug screening and therapeutics.

The liver is one of the most complex organs in the body, performing a multitude of functions. Liver tissue engineering is a combination of various strategies that aim at generating functional liver tissue that can help restore and/or support the ailing liver as it recuperates. Conventionally, in vitro culture has involved growing cells in different media compositions or layering them on matrices largely composed of native ECM components such as collagen or Matrigel. With recent advances in technology, more sophisticated techniques are being devised that are better equipped to capture distinct features of the liver in an in vivo microenvironment. Three-dimensional (3D) cultures of liver cells in 3D scaffolds, as spheroids or cell sheets, allow for a high degree of cell-cell and cell-matrix interaction and an in vivo-like architecture. More recently, decellularized matrices have been used as scaffolds that support ideal cell-matrix interactions. Microfabrication technologies initially used to pattern semiconductors in the integrated circuit industry have grown out of this field and now encompass a variety of methods to etch patterns onto both 2D and 3D scaffolds to allow incorporation of custom-made features resembling the fluid network and organization in native liver. This improvisation permits for enhanced vascularization and oxygen diffusion to the in vitro liver tissue. In this review, we discuss the various configurations that have been implemented in the in vitro culture of liver cells and their application in liver therapeutics in the form of implantable liver tissue constructs and tools for drug screening.

Prioritizing sustainability strategies for global extractive sector firms

PurposeThis paper seeks to examine the importance of corporate social and environmental initiatives to extractive sector firms and by measuring the level of social, environmental and economic sustainability in 128 countries around the world and applying these measures to a framework comprised of a sustainability indices matrix, and identifying certain strategic approaches to social and environmental practices.Design/methodology/approachThe matrix contains eight categories of sustainability attainment and a k‐means cluster analysis is employed to identify what countries belong to each of these categories and to what extent these clusters identify countries with similar characteristics that may impact the focus of corporate social and environmental performance practices for extractive sector firms wishing to pursue projects in those countries.FindingsThe study finds that, in those jurisdictions where social and environmental sustainability is well established, extractive sector firms are required to deal with established rules and regulations that require a more reactive strategic approach. The various combinations of sustainability levels amongst the many countries around the globe require various combinations of strategies related to corporate social and environmental performance.Practical implicationsThe realization that, today, extractive sector firms who choose to ignore the need for appropriate corporate social and environmental performance are risking increased costs arising from social and environmental damage created by their projects supports the need to create pro‐active strategies for addressing social and environmental responsibility.Originality/valueThis paper's contribution is the development of a framework for measuring the component levels of sustainable development and clustering a large number of countries into specific categories with recommended approaches to social and environmental sustainability strategies.

A High Performance Three-Phase Telecom Supply Incorporating a HF Switched Mode Rectifier with a Phase Shifted PWM Controller

Telecom supplies need to conform to low Total Harmonic Distortion (THD) and high Power Factor (PF) as per IEC 61000-3-2 and IEEE 519-1992 standards. These high rating power supplies use a three phase utility in which low THD and high PF are realized via various passive and active wave shaping schemes. In this paper, a new design for three phase telecom power supplies is presented with circuit parameter values optimized for high performance in terms of a low THD, high PF, low ripple and high line and load regulation using a suitable combination of various strategies. The performance of the power supply is validated by extensive simulations.