Combat Substance Abuse Research Articles

Acceptability of Peer Networking Strategy in Combating Substance Abuse Among Undergraduates in Universities in Anambra State

Substance abuse among the youths has been on the increase despite efforts of government and other concerned institutions to combat it. The university system in Nigeria is not exempt from this cankerworm. These citadels of learning, as it is, grapple with the challenge of indiscriminate substance use among undergraduates. It is against the backdrop of the prevalence of substance abuse among undergraduates and the consequent failures of so many strategies to combat abuse that this study investigated the acceptability of peer networking as an alternative public relations strategy for combating substance abuse among undergraduates of universities in Anambra State. The study was conducted in the light of the Theoretical Framework of Acceptability (TFA) propounded by Sekhon et al (2017). Using a descriptive survey design, the study surveyed a sample of 200 undergraduates from universities in Anambra State to ascertain their perspective on the acceptability of the proposed peer networking strategy in combating substance abuse. A questionnaire titled ‘Peer Networking for Combating Substance Abuse Questionnaire (PNCSAQ) was developed and used to obtain data from the undergraduates. The PNCSAQ was validated and the reliability coefficient index of 0.86 was obtained. Data collected for the study were analysed with descriptive statistics. Findings indicated that undergraduates despite their diverse demographic characteristics accepted peer networking as a good strategy for combating substance abuse in the universities. Based on the findings, it was recommended among other things, that PR managers should employ the peer networking strategy in combating substance abuse among undergraduates in the universities.

EFFECTIVENESS OF THE THERAPEUTIC COMMUNITY INTERVENTION PROGRAM OF THE DEPARTMENT OF HEALTH-TREATMENT AND REHABILITATION CENTER (DOH-TRC)

This study aimed to assess the effectiveness of the Therapeutic Community Intervention Program operated by the Department of Health-Treatment and Rehabilitation Center (DOH-TRC) in the Philippines. The research focused on four components of the program, namely the Residential, Outpatient, Aftercare, and Recovery Home programs. The study determined the areas of success and those requiring improvement to enhance the overall effectiveness of each program. Structured questionnaires and surveys were administered to two groups of respondents-program staff and patients-who had received the respective intervention programs. The survey questions were designed to evaluate the effectiveness of various aspects of the programs, such as treatment plan individualization, program implementation fidelity, program structure, family involvement, patient support systems, post-treatment monitoring, relapse prevention, and post-recovery support. The statistical analysis revealed significant insights into the effectiveness of each program. The Residential and Recovery Home programs received high mean scores, indicating that staff and patients perceived them as highly effective. However, the Outpatient and Aftercare programs demonstrated areas requiring attention and improvement. The Outpatient Program showed that family support, patient anxiety towards reintegration into the community, and the absence of a program for patient and family interaction were significant concerns. For the Aftercare Program, areas of concern included the lack of a structured patient monitoring system and financial support for staff assigned to monitor aftercare patients. The findings offered valuable insights into areas that needed enhancement to ensure optimal patient outcomes. Based on the data findings, a comprehensive action plan was developed to improve the effectiveness of the Therapeutic Community Intervention Program. The action plan involved specific key performance indicators, activities, budget allocations, timelines, personnel involvement, and continuous quality improvement efforts tailored to each program. The study provided information on the advantages and disadvantages of the Therapeutic Community Intervention Program implemented by DOH-TRC. By implementing the proposed action plan, the center can further improve the effectiveness of its Residential, Outpatient, Aftercare, and Recovery Home programs, ultimately leading to better patient outcomes and contributing to the programs overall success in combating substance abuse and promoting lasting recovery. Continuous evaluation and improvement will be essential to ensure the program remains responsive to the evolving needs of its participants and consistently delivers high-quality care. KEYWORDS: Rehabilitation, Residential Program, Outpatient Program, Aftercare Program, Recovery Home Program

Magic Mushrooms

Psilocybin is a naturally occurring compound present in numerous mushroom species characterised by its hallucinogenic and psychedelic effects. Although it has a negative reputation, psilocybin has demonstrated therapeutic potential for treating mental health disorders by allowing the brain to make new neural connections which help the neural pathways adapt and break out of certain cognitive patterns related to mental illness. In recent studies, psilocybin has shown antidepressant effects, significantly reducing depressive and anxious symptoms in affected individuals. After single or low dosage, mood disorder symptoms remained in remission for 6 to 12 months. In contrast, conventional antidepressants often require multiple doses over long treatment periods to achieve similar effects. Other findings have shown that therapeutic use of psilocybin helps combat substance abuse and addictive disorders and can be applied as a cessation tool. Despite years of controversy surrounding the benefits of psilocybin, recent scientific evidence supports psilocybin’s immense potential in helping those with mental health disorders like Major Depressive Disorder (MDD), Generalised Anxiety Disorder (GAD), Post Traumatic Stress Disorder (PTSD), Obsessive-Compulsive Disorder (OCD), and addiction disorders. With such promising results, psilocybin could be incorporated into clinical use and its therapeutic effects should continue being researched.

Exploring Roles of Stakeholders in Combating Substance Abuse in the DIMAMO Surveillance Site, South Africa.

The increasing prevalence of substance abuse in rural areas of Limpopo Province is a concern for most stakeholders including the families, South Africa Police Service, and social workers. Combating Substance Abuse requires the active roles of various stakeholders in the rural community, due to limited resources for prevention, treatment, and recovery. To report on the roles of stakeholders in tackling Substance Abuse during the awareness campaign conducted in the deep rural community of Limpopo Province, DIMAMO surveillance area. Qualitative narrative design was adopted to explore the roles of stakeholders in combating Substance Abuse during the awareness campaign conducted in the deep rural community. The population consisted of different stakeholders who play an active role in reducing Substance Abuse. The triangulation method was used for data collection (interviews, observations, and taking field notes during presentations). Purposive sampling was used to select all the available stakeholders who actively combat substance abuse in the communities. Thematic narrative analysis was used to analyze the interviews conducted with and content presented by the stakeholders to generate the themes. The prevalence of Substance Abuse among the youth in the Dikgale community is high with a growing trend of Crystal Meth, "nyaope," and Cannabis(marijuana). The prevalence is worsened by the diverse challenges experienced by the families and stakeholders which impact the strategies targeted to combat Substance Abuse. The findings indicated the need for strong collaborations among the stakeholders (including school leadership) to successfully combat Substance Abuse in rural areas. The findings demonstrated a need for a well-capacitated healthcare services with adequate rehabilitation centers and well-trained healthcare providers for combating Substance Abuse to minimize victim stigmatization.

Magic Mushrooms

Psilocybin is a naturally occurring compound present in numerous mushroom species characterised by its hallucinogenic and psychedelic effects. Although it has a negative reputation, psilocybin has demonstrated therapeutic potential for treating mental health disorders by allowing the brain to make new neural connections which help the neural pathways adapt and break out of certain cognitive patterns related to mental illness. In recent studies, psilocybin has shown antidepressant effects, significantly reducing depressive and anxious symptoms in affected individuals. After single or low dosage, mood disorder symptoms remained in remission for 6 to 12 months. In contrast, conventional antidepressants often require multiple doses over long treatment periods to achieve similar effects. Other findings have shown that therapeutic use of psilocybin helps combat substance abuse and addictive disorders and can be applied as a cessation tool. Despite years of controversy surrounding the benefits of psilocybin, recent scientific evidence supports psilocybin’s immense potential in helping those with mental health disorders like Major Depressive Disorder (MDD), Generalised Anxiety Disorder (GAD), Post Traumatic Stress Disorder (PTSD), Obsessive-Compulsive Disorder (OCD), and addiction disorders. With such promising results, psilocybin could be incorporated into clinical use and its therapeutic effects should continue being researched.

Trends in Substance Use and Abuse During COVID-19 Among the General Population.

COVID-19 pandemic has brought many public health issues, including substance use and abuse. Individuals abusing substances are vulnerable to severe infections caused by SARS-CoV-2 virus as well as impairment of the immune system, mental health, and physical health. Despite considerable efforts to minimize and prevent substance use, the use of tobacco, alcohol, and illicit substances is ever increasing resulting in morbidity and mortality which significantly leads to socio-economic costs. A quantitative review of the literature searched in PubMed and Google Scholar databases yielded a total of 1416 studies among which 27 cross-sectional studies, conducted on the general population of 15 and above years of age, were selected based on the eligibility criteria. A sample of 1,021,118 individuals were investigated in this study. The most commonly used substances were marijuana (100%), methadone (69.86%), and large cigar (60%). A total of 26 substances were reported to have been used during pandemic, 13 of which showed trends in usage (increased/decreased/no change). Of the total sample, 45.89% were males, 54.14% females, and 1.28% others. Everyone and anyone is susceptible to alcohol, tobacco, and other substance use and abuse at different stages of their lives. Therefore, the need for effective preventive strategies is critical in community efforts to combat substance abuse. Combined efforts from local and global stakeholders will lead to curbing the issue of substance use and abuse worldwide.

Borderline Personality Disorder: Clinical Guidelines for Treatment.

Borderline personality disorder (BPD) is fundamentally a syndrome composed of symptoms (primarily of emotional dysregulation) and a number of true personality traits (such as inordinate anger, impulsivity, and a tendency to stress-related paranoid ideation). Whereas schizotypal personality disorder, with its cognitive peculiarities (ideas of reference, odd beliefs, eccentric speech), is closely linked as a genetic condition-"borderline" to the major condition schizophrenia-BPD is less closely linked to bipolar disorder. Some cases of BPD are linked genetically to and are in the "border" of bipolar disorder. But the condition can also arise from adverse post-natal factors: parental cruelty or neglect, or incest. In some BPD patients, both are present: risk genes for bipolar disorder and adverse conditions within the family. The genetic risk is often overlooked. To avoid this, initial evaluations should always include a careful and extensive family history for mood disorders, and should extend out to grandparents, aunts, uncles, and cousins. Where the history suggests a genetic link to bipolar disorder, a mood stabilizer such as lithium or lamotrigine, even in modest doses, may be particularly beneficial, more so than conventional antidepressants. In some patients, ADHD was present in childhood, BPD was diagnosed during or after puberty, and a form of bipolar disorder becomes apparent during their 20s. As for the psychotherapeutic component, the patient's cognitive style and capacity for introspection will help determine whether a primarily expressive (psychoanalytically oriented) technique is preferable or a primarily cognitive-behavioral technique. Flexibility is necessary, since during emotional crises, supportive and limit-setting interventions will be needed, along with psychotropic medications, and where necessary, programs to help combat substance abuse (which is common among patients with BPD).

The role of glia in the physiology and pharmacology of glucagon-like peptide-1: implications for obesity, diabetes, neurodegeneration and glaucoma.

The medical applications of glucagon-like peptide-1 receptor (GLP-1R) agonists is evergrowing in scope, highlighting the urgent need for a comprehensive understanding of the mechanisms through which GLP-1R activation impacts physiology and behaviour. A new area of research aims to elucidate the role GLP-1R signalling in glia, which play a role in regulating energy balance, glycemic control, neuroinflammation and oxidative stress. Once controversial, existing evidence now suggests that subsets of glia (e.g. microglia, tanycytes and astrocytes) and infiltrating macrophages express GLP-1Rs. In this review, we discuss the implications of these findings, with particular focus on the effectiveness of both clinically available and novel GLP-1R agonists for treating metabolic and neurodegenerative diseases, enhancing cognition and combating substance abuse. LINKED ARTICLES: This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc.

Self-Efficacy and Its Influence on Job Satisfaction Among Substance Abuse Prevention Program Teachers

Drug prevention and education program had been implemented in schools through special Substance Abuse Prevention Program (PPDa). The purpose of this study was to identify self-efficacy, job satisfaction and their relationships among PPDa teachers. This study also measured the differences in self-efficacy and job satisfaction based on gender and experiences in handling PPDa program. The researcher used snowball sampling technique to recruit 150 PPDa teachers in Malaysia. The translation version of 'General Self-efficacy Scale' and Job Descriptive Index (JDI) were used to achieve the research objectives. The findings showed that PPDa teachers are at the moderate level of self-efficacy and low level of job satisfaction. There was no significant difference in self-efficacy based on gender and experience in handling PPDa program. There was also no significant difference in job satisfaction based on experience in handling PPDa program. However, there was a significant difference in job satisfaction based on gender. The findings also revealed that there was a significant positive relationship between self-efficacy and the level of job satisfaction (rs=.277, p=0.01). The findings revealed that further enhancement could improve teachers’ self-efficacy and job satisfaction to combat substance abuse in school level.

Compulsory income management: Combatting or compounding the underlying causes of homelessness?

AbstractCompulsory Income Management (CIM) is a form of conditional welfare that involves the mandatory quarantining of a portion of welfare recipients’ social security payments. Quarantined funds are accessible via a government‐issued debit card, with restrictions surrounding where and on what funds can be spent. Official justifications of CIM have framed these policies as attempts to combat substance abuse and gambling problems, and to thus secure better outcomes for welfare recipients and their families. Central to this narrative has been the argument that welfare quarantining will ensure more money is spent on ‘essentials’, including accommodation. No existing studies, however, have specifically interrogated the impacts of CIM on housing security. This article responds to this gap in the literature by reviewing existing research concerning CIM's impacts and locating this research within broader debates regarding the causes of homelessness and the efficacy of individualised policy interventions. In doing so, it highlights CIM's potential to exacerbate housing insecurity not only through technical issues such as rental transfer failures, but also by contributing to underlying stressors such as economic disadvantage; relationship difficulties, poor health and addiction; and social stigma. The article concludes that – far from addressing the structural causes of homelessness – CIM has enflamed them.

Family Communication Patterns, Inoculation Theory, and Adolescent Substance‐Abuse Prevention: Harnessing Post‐Inoculation Talk and Family Communication Environments to Spread Positive Influence

Inoculation theory offers a robust way to combat substance abuse among children. The theory can guide a messaging strategy that prepares for challenges before they are fully experienced. We argue that inoculation as a messaging strategy could be made even more robust by harnessing family communication patterns and post‐inoculation talk to lead to more, and better, parent–child dialogue. We build on the literature on inoculation and family communication patterns to offer four propositions to guide future work in this area, including the efficacy of inoculating parents against tendencies to avoid conversations about substance abuse with their children and the likelihood of inoculation‐based messages leading to continuing talk in families.

Influence of regional differences in substance use disorders

Objective: In this study, it was planned to determine regional differences in terms of sociodemographic and clinical features of patients with substance use disorder. Methods: The files of 557 patients diagnosed with substance dependence between January 2016 and June 2016 were retrospectively reviewed. Age, education, marital status, number of hospital admissions, type of substance used, duration of substance use, province and geographical region of the patients were evaluated. Results: The mean age of 557 patients was 27.73±8.33 and 97.1% were male, 65.7% were primary school graduates and 42.4% were single. Of the patients, 63.2% were living in the Western Black Sea (WBS), 15.4% in the Central Anatolia (CA), 13.1% in the Marmara region (MR) and 8.3% in other regions. The most common multiple substance was used mostly cannabis (Cn) except CA. The age at onset of substance was the lowest on MR (8-15 years). In all regions, a request for voluntary treatment was more than the other forms of referral. The rate of detainees/convicts is lower in the WBS compared to other regions. There was no significant difference between the mean duration of substance use, age and number of applications in terms of geographical regions. Discussion: When the results of this study were evaluated together with the previous studies, it indicates that the substance used and the age of onset differed not only between the regions experienced but also within the same region over the years. Regional differences may require the use of different strategies to combat substance abuse. Therefore, such studies should be repeated at regular intervals and new monitoring tools should be used.

Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference

Stress increases the likelihood of cocaine relapse in humans and animals, even following a prolonged extinction/abstinence period. Exercise has previously been shown to reduce stress and decrease the likelihood of drug dependence, while also reducing cravings in humans and inhibiting relapse behaviors due to other risk factors in rodents. The present study evaluated the efficacy of exercise to reduce stress-induced relapse to cocaine in a rodent model. Young adult female Sprague Dawley rats were tested for cocaine conditioned place preference (CPP), then split into sedentary or exercise (six weeks of one-hour daily treadmill running, five days per week) groups. Following cocaine CPP, rats were tested for extinction behavior, and then tested for stress-primed reinstatement (15 min immobilization) following the six-week intervention period. Exercise inhibited stress-induced reinstatement of cocaine CPP despite increasing serum corticosterone levels following 15 min of immobilization, suggesting that chronic aerobic exercise intervention may result in adaptations of stress pathways. These findings suggest that exercise may help prevent stress-induced drug relapse, adding to a growing body of evidence supporting the utility of exercise to combat substance abuse.

SUBSTANCE ABUSE AND THE WORKPLACE: A SITUATION ANALYSIS

Substance abuse among the employed in South Africa has increased in recent years with major economic consequences for employers. Specialist outpatient treatment programmes are available to employers, yet few employees are inducted into these programmes. A situation analysis was conducted to explore possible reasons for this state of affairs. This article provides an overview of workplace-related limiting factors in combating substance abuse and also covers the resources needed to deal with the problem of substance abuse in the workplace. The authors suggest collaboration between employers and outpatient treatment centres as a viable solution.

Combating substance abuse with the potential of geographic information system combining multivariate analysis

Substance abuse problems have been a growing concern for people from all over the world. The objective of this study is to demonstrate the usefulness of a combination between a geographic information system and a multivariate analysis in substance abuse research. However, due to the limited studies on a combination of both these methods in the substance abuse field, we review some other studies in various fields indicating the potential of this method in future substance abuse studies. As the expertise of GIS lies in spatial analysis and the multivariate analysis lies in analyzing huge data thus being capable of interpreting the results very well, we hope this method will attract researchers to applying it in their studies and can consequently and indirectly help in combating substance abuse problems. Keywords: substance abuse; geographic information system; multivariate analysis; spatial analysis; combat

Substance abuse at Jordanian universities: Perspectives of pre-service special education teachers

ABSTRACTThe aim of this large-scale in-depth interview study was to investigate special education student-teachers’ perspectives on substance abuse and measures for combating it in Jordanian universities. Participants were 202 special education pre-service teachers who were purposively selected from three universities for open-ended interviews following a broadly structured guide. Content analysis was used to examine responses which were summarized into five major themes: (1) prevalence of substance abuse among students, (2) reasons for substance abuse, (3) the university experience as a risk for substance abuse, (4) adequacy of substance abuse services, and (5) possible solutions for addressing substance abuse. Informants perceived substance abuse among their student peers as pervasive, with the leading substances being tobacco and water-pipe smoking, followed by marijuana, synthetic marijuana (“joker”) and alcohol for men. For women, water-pipe smoking was perceived as the most common with tobacco notable. Students expressed that the university experience was a risk for substance abuse, that substance abuse education at their university was inadequate, and that a desire for more services to combat substance abuse existed. Recommendations are provided concerning the role of universities in substance abuse education and programs to combat substance abuse.

A Systems Dynamic Model for Drug Abuse and Drug-Related Crime in the Western Cape Province of South Africa.

The complex problem of drug abuse and drug-related crimes in communities in the Western Cape province cannot be studied in isolation but through the system they are embedded in. In this paper, a theoretical model to evaluate the syndemic of substance abuse and drug-related crimes within the Western Cape province of South Africa is constructed and explored. The dynamics of drug abuse and drug-related crimes within the Western Cape are simulated using STELLA software. The simulation results are consistent with the data from SACENDU and CrimeStats SA, highlighting the usefulness of such a model in designing and planning interventions to combat substance abuse and its related problems.

APhA honors outstanding achievements at Annual Meeting

Each year, APhA recognizes exceptional contributors to the profession at the Annual Meeting. The following award winners will be honored at APhA2014 in Orlando.

1-Methyl-1,2,3,4-Tetrahydroisoquinoline, an Endogenous Amine with Unexpected Mechanism of Action: New Vistas of Therapeutic Application

This review outlines the effects of 1,2,3,4-tetrahydroisoquinoline (TIQ) and its derivative, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), endogenous substances imbued with high pharmacological potential and broad spectrum of action in brain. 1MeTIQ has gained special interest as a neuroprotectant, and its ability to antagonize the behavioral syndrome produced by well-known neurotoxins (e.g., MPTP; rotenone). This review is thus focused on mechanisms of action of 1MeTIQ in behavioral, neurochemical, and molecular studies in rodents; also, effects of TIQ and 1MeTIQ on dopamine metabolism; and neuroprotective properties of TIQ and 1MeTIQ in vitro and in vivo. Finally, antiaddictive properties of 1MeTIQ will be described in cocaine self-administered rats. Findings implicate TIQ and especially its methyl derivative 1MeTIQ in unique and complex mechanisms of neuroprotection in various neurodegenerative illnesses of the central nervous system. We believe that MAO inhibition, free radicals scavenging properties, and antagonism to the glutamatergic system may play an essential role in neuroprotection. In addition, the results strongly support the view that 1MeTIQ has a considerable potential as a drug for combating substance abuse, through the attenuation of craving.

News and Notes

News and Notes