Prevalence Of Colorectal Polyps Research Articles

Prevalence of colorectal polyps in patients undergoing colonoscopy in Sulaimaniyah gastroenterology center: a retrospective study

Background & objectives: Colorectal cancers are believed to develop primarily through an adenoma-carcinoma sequence, with adenomatous polyps beginning as the primary precursor lesions. Thus, this study aimed to assess the prevalence of colorectal polyps with their characteristics and relation to age/gender and to aid in establishing a screening program to detect polyps and colorectal cancer in the early stages. Methods: In this retrospective study, the data of 2698 patients who underwent colonoscopy in Sulaimani Gastroenterology Center, Sulaimaniyah, Iraq, for various complaints and asymptomatic patients from January 2019 to February 2021 were studied regarding colorectal polyps. Patients sociodemographic data (age, gender, and residency), presented symptoms, surveillance rate for colon cancer and polyps, and disease follow-up were studied. Briefly, patients were given bowel preparation solutions the day before the colonoscopy, and the process was performed under conscious sedation. Results: The mean±SD age of patients was 52.0±17.59 years, and most were females (55.1%)(p=0.000) and from urban areas (62.12%) (p?0.05). Among the studied patients, 14.3% were diagnosed with polyps, of which 17.1% were males and 12.1% were females. The high prevalence rate was found in patients aged >60 years (23.8%), followed by 50-60 years (17.71%), and then 40-49 years (13.07%). Conclusion: Colorectal polyp was common among patients undergoing colonoscopy for several gastrointestinal symptoms, especially after the age of forty.

Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps

BackgroundMost colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps.MethodsInpatients admitted from January 2018 to May 2023 were screened through the hospital information system. Polyps were classified according to pathological morphology. The prevalence of polyps was described by frequency and 95% confidence interval. Univariate and multivariate logistic regression analyses were used to explore the risk factors for CCS and neoplastic polyps.ResultsIn total, 2329 individuals with 3550 polyps were recruited. Among all patients, 76.99% had neoplastic polyps and 44.31% had advanced adenomas. Tubular adenoma had the highest prevalence at 60.15%, and the prevalence of CCS was 3.86%. Patients with a colorectal polyp diameter ≥ 1.0 cm or number ≥ 3 were 8.07 times or 1.98 times more likely to develop CCS than were those with a diameter < 1.0 cm or number < 3, respectively (OR 8.07, 95%CI 4.48–14.55, p < 0.0001; and OR 1.98, 95%CI 1.27–3.09, p = 0.002). The risk of CCS with schistosome egg deposition was also significantly increased (OR 2.70, 95%CI 1.05–6.98). The higher the levels of carbohydrate antigen (CA) 724 (OR 1.01, 95%CI 1.00–1.02) and CA211 (OR 1.16, 95%CI 1.03–1.32) in patients with colorectal polyps were, the greater the risk of CCS. When colorectal neoplastic polyps were analyzed, we discovered that for each 1-year increase in age, the risk of neoplastic polyps increased by 3% (OR 1.03, 95%CI 1.02–1.04), p < 0.0001. Patients with a polyp diameter ≥ 1.0 cm had a 2.11-fold greater risk of neoplastic polyps compared to diameter < 1.0 cm patients (OR 3.11, 95%CI 2.48–3.92), p < 0.0001. In addition, multiple polyps and CA199 levels are risk factors for neoplastic polyps.ConclusionMore than 3/4 of colorectal polyp patients have neoplastic polyps. Patients are more inclined to develop CCS and neoplastic polyps if they have large polyps (> 1.0 cm) or multifocal polyps. The levels of the tumor markers CA724 and CA211 show some potential usefulness for predicting CCS and may be exploited for early identification of high-risk populations.

Fruit but not vegetable consumption is beneficial for low prevalence of colorectal polyps in a high-risk population: findings from a Chinese Lanxi Pre-colorectal Cancer Cohort study.

The available evidence regarding the role of fruit and vegetable consumption in the development of colorectal polyps remains inconclusive, and there is a lack of data on different histopathologic features of polyps. We aimed to evaluate the associations of fruit and vegetable consumption with the prevalence of colorectal polyps and its subtypes in a high-risk population in China. We included 6783 Chinese participants aged 40-80 years who were at high risk of colorectal cancer (CRC) in the Lanxi Pre-colorectal Cancer Cohort (LP3C). Dietary information was obtained through a validated food-frequency questionnaire (FFQ), and colonoscopy screening was used to detect colorectal polyps. Dose-response associations of fruit and vegetable intake with the prevalence of polyps were calculated using multivariate-adjusted regression models, which was reported as odds ratios (ORs) with 95% confidence intervals (CIs). 2064 cases of colorectal polyps were ascertained in the LP3C during 2018-2019. Upon multivariable adjustments, including the diet quality, fruit consumption was inversely associated with the prevalence of polyps (P trend = 0.02). Participants in the highest tertile of fruit intake had a 25% lower risk (OR: 0.75; 95% CI 0.62‒0.92) compared to non-consumers, while vegetable consumption had no significant association with polyp prevalence (P trend = 0.86). In terms of colorectal histopathology and multiplicity, higher fruit intake was correlated with 24, 23, and 33% lower prevalence of small polyps (OR: 0.76; 95% CI 0.62‒0.94; P trend = 0.05), single polyp (OR: 0.77; 95% CI 0.62‒0.96; P trend = 0.04), and distal colon polyps (OR: 0.67; 95% CI 0.51‒0.87; P trend = 0.003), respectively. Fresh fruit is suggested as a protective factor to prevent colorectal polyps in individuals at high risk of CRC, and should be underscored in dietary recommendations, particularly for high-risk populations.

Association between triglyceride-glucose index and colorectal polyps: A retrospective cross-sectional study.

Colorectal polyps (CPs) are frequently occurring abnormal growths in the colorectum, and are a primary precursor of colorectal cancer (CRC). The triglyceride-glucose (TyG) index is a novel marker that assesses metabolic health and insulin resistance, and has been linked to gastrointestinal cancers. To investigate the potential association between the TyG index and CPs, as the relation between them has not been documented. A total of 2537 persons undergoing a routine health physical examination and colonoscopy at The First People's Hospital of Kunshan, Jiangsu Province, China, between January 2020 and December 2022 were included in this retrospective cross-sectional study. After excluding individuals who did not meet the eligibility criteria, descriptive statistics were used to compare characteristics between patients with and without CPs. Logistic regression analyses were conducted to determine the associations between the TyG index and the prevalence of CPs. The TyG index was calculated using the following formula: Ln [triglyceride (mg/dL) × glucose (mg/dL)/2]. The presence and types of CPs was determined based on data from colonoscopy reports and pathology reports. A nonlinear relation between the TyG index and the prevalence of CPs was identified, and exhibited a curvilinear pattern with a cut-off point of 2.31. A significant association was observed before the turning point, with an odds ratio (95% confidence interval) of 1.70 (1.40, 2.06), P < 0.0001. However, the association between the TyG index and CPs was not significant after the cut-off point, with an odds ratio (95% confidence interval) of 0.57 (0.27, 1.23), P = 0.1521. Our study revealed a curvilinear association between the TyG index and CPs in Chinese individuals, suggesting its potential utility in developing colonoscopy screening strategies for preventing CRC.

Nonalcoholic or metabolic-associated fatty liver disease and colorectal polyps: evidence from meta-analysis and two-sample Mendelian randomization.

Nonalcoholic or metabolism-associated fatty liver disease (NAFLD or MAFLD) and colorectal polyps are chronic conditions strongly linked to lifestyle factors. However, the precise causal link between NAFLD or MAFLD and the development of colorectal polyps is not yet fully understood. This study aimed to evaluate the association between NAFLD or MAFLD and the risk of colorectal polyps based on a meta-analysis and two-sample Mendelian randomization (MR) analyses. PubMed, Embase, Cochrane Library databases were searched for eligible studies to be included in the meta-analysis. We conducted a thorough search of the PubMed, Embase, and Cochrane Library databases to identify eligible studies prior to 22 March 2024. Subgroup analyses were performed based on sex, age, and geographical region. Causality between NAFLD/MAFLD and colorectal polyps was explored by using two-sample Mendelian randomization (MR) analyses. Based on an analysis of 17 studies encompassed within this meta-analysis, a significant correlation was identified between the presence of NAFLD/MAFLD and elevated incidence of colorectal polyps (NAFLD: OR = 1.57, 95% CI: 1.43-1.73, I2 = 38%, p = 0.06; MAFLD: OR = 1.67, 95% CI: 1.40-2.00, I2 = 77%, p = 0.002). However, current evidence does not support a causal relationship between NAFLD/MAFLD and the prevalence of colorectal polyps (OR = 0.9998315, 95% CI: 0.9987566-1.000907, P = 0.7587638). NAFLD/MAFLD demonstrated a significant positive correlation with an elevated risk of developing colorectal polyps. However, the MR analysis suggested that no causal relationship existed between NAFLD/MAFLD and colorectal polyps. Therefore, further research is required to identify the underlying mechanism of causal link between these diseases.

Colonoscopic and histopathological assessment of colorectal polyps among north Indian population

Background: Colonic polyps are the abnormal growths from the colonic mucosa, usually benign but there is a definite though a small risk for cancerous transformation. Scarce data about this condition is available from Northern India. In this study we aimed to determine the prevalence of colonic polyps in patients undergoing colonoscopy for various health indications. In addition, we studied the various characteristics of these polyps including the histological classification Methods: In this observational cross-sectional study we included adult patients (≥18 years) who underwent colonoscopy from July 2016 to June 2018 at a tertiary care hospital setting in New Delhi, India. The socio-demographic variables were ascertained for all patients. Data about indication of colonoscopy, the findings on colonoscopy, finding regarding the colonic polyps (type, number, size, location and histological type) was collected. Results: We found a total of 246 patients to have colonic polyps and total number of polyps found was 369.The median age of the patients was 56 years (IQR 44-68). Majority of the patients with polyps (74.8%) were males. Polyps were most commonly seen in left colon (35.36%). Histologically, most common type was adenomatous polyps 58.9% (Tubular adenoma in 44% and tubule-villous adenoma in 8%). Hyperplastic polyps were noted in 22% followed by inflammatory polyps in 14% polyps. Adenocarcinoma was reported in 2 polyps (0.8%). Conclusions: Prevalence of colorectal polyps in our study is lower compared to most of the western countries. On histology majority of polyps were adenomatous.

Association of CDH1 Germline Variants and Colon Polyp Phenotypes in Patients with Hereditary Diffuse Gastric Cancer.

Germline CDH1 variants resulting in E-cadherin loss of function result in an increased risk of diffuse type gastric cancer and lobular type breast cancer. However, the risk of developing other epithelial neoplasms, specifically colorectal cancer, is unknown. Patients enrolled in a prospective natural history study of hereditary gastric cancer who underwent at least one colonoscopy were evaluated. Out of 300 patients with CDH1 pathogenic or likely pathogenic variants, 85 underwent colonoscopy. More than half of patients (56%, 48/85) had at least one colorectal polyp. Most of those patients (83%, 40/48) had at least one precancerous polyp (adenoma or sessile serrated lesion). More than half (56%) of patients younger than age 45 had a colorectal polyp. Of those with polyps, the most frequent CDH1 variant type was canonical splice site (27%, 13/48) followed by nonsense (21%, 10/48). There was no association between CDH1 variant type and increased likelihood of colorectal polyps. In summary, a majority of CDH1 variant carriers who underwent colonoscopy had colorectal polyps detected, and most subjects were less than 45 years old. This study of colorectal cancer risk based on the prevalence of colorectal polyps in the CDH1 population requires further investigation to appropriately counsel patients on colorectal cancer screening. Clinical trial registry website: https://clinicaltrials.gov/. Clinical trial number: NCT03030404.

Prevalence of colorectal polyps and associated risk factors in Egyptian population: A single center study

Prevalence of colorectal polyps and associated risk factors in Egyptian population: A single center study

Association of egg consumption with colorectal polyp prevalence: findings from the Lanxi Pre-Colorectal Cancer Cohort (LP3C) in China.

Eggs contain high-quality protein, lavish vitamins and other bioactive nutrients but are rich in cholesterol. Our study is designed to assess the association of egg intake with polyp prevalence. A total of 7068 participants at a high risk of CRC from the Lanxi Pre-Colorectal Cancer Cohort Study (LP3C) were recruited. A food frequency questionnaire (FFQ) was utilized to obtain dietary data through a face-to-face interview. Cases of colorectal polyps were identified by electronic colonoscopy. The logistic regression model was exploited to achieve odds ratios (ORs) and 95% confidence intervals (CIs). Overall 2064 cases of colorectal polyps were identified in the 2018-2019 survey of LP3C. A positive association of egg consumption with colorectal polyp prevalence was found after the multivariable adjustment [ORQ4 vs. Q1 (95% CI): 1.23 (1.05-1.44); Ptrend = 0.01]. However, a positive relationship disappeared after further adjustment for dietary cholesterol (Ptrend = 0.37), which explained that the harmful role of eggs could be ascribed to the high content of dietary cholesterol. Besides, a positive trend was found between dietary cholesterol and polyp prevalence [OR (95% CI): 1.21 (0.99-1.47); Ptrend = 0.04]. Furthermore, replacing 1 egg (50 g d-1) with an equal amount of total dairy products was related to 11% lower colorectal polyp prevalence [OR (95% CI): 0.89 (0.80-0.99); P = 0.03]. In summary, higher egg consumption was correlated with a higher polyp prevalence among the Chinese population at a high risk of CRC, which was ascribed to the high content of dietary cholesterol in eggs. Besides, individuals with the highest dietary cholesterol tended to have a higher polyp prevalence. Reducing the consumption of eggs and replacing eggs with total dairy products as alternative protein sources may prevent the occurrence of polyps in China.

Patterns and Types of Colorectal Polyps Among Adults in Imo State Nigeria

Background: Colorectal cancer is one of the major health problems in the world. It used to be thought that it is a disease of people in developed countries, but recent studies has shown increasing incidence in developing countries. In Nigeria, most patients present cases late when curative resection is impossible. In order to achieve higher success, it becomes essential that knowledge and awareness for early symptoms and detection methods and screening tools have to be identified. This study aimed to elucidate the patterns and types of colorectal polyps among adults aged 40 – 65 years of age in Imo State Nigeria. Methods: The sample of the study comprised one thousand (1000) adults drawn through a multistage sampling method, and included both urban and rural dwellers from the selected communities in Imo State, Nigeria. These were screened for Fasting Occult Blood Test (FOBT). Out of the, 40 (4. 0%) of the subjects found to be positive, a further random selection was used to select 20 (50.0%) for virtual colonoscopy for detection of colorectal polyps. Results: Findings showed that there was evident in the low prevalence of colorectal polyps (20%). Also, there was a significant association between the patterns of colorectal polyp and awareness of colorectal polyp among the participants (p= 0.001; X2= 7.153). Conclusion: There are different types of colon polyps with differing tendencies to become malignant and abilities to predict the development of polyps to cancer. It is important to recognize families with members who have genetic conditions causing polyps because some of these conditions are associated with a very high incidence of colon cancer, and the cancer can be prevented if discovered early

Clinical, endoscopic, histopathological characteristics of patients with colorectal polyps - Endoscopy Gastroenterology Center, Hue University of Medicine and Pharmacy Hospital

Background: Colorectal polyps are a relatively common diseases in the group of lower gastrointestinal tract diseases. The prevalence of colorectal polyps ranges from 20 to 50%. Polyps are formed due to excessive hyperplasia of the mucosa and the malignancy rate of colorectal polyps is higher than other sites. Objectives: (1) To describe some clinical and endoscopic features of colorectal polyps; (2) To evaluate the histopathological characteristics and the relationship between histopathology and some clinical and endoscopic features of colorectal polyps. Subjects: The patients aged 16 years old and older who were diagnosed with colon polyps at the Center for Gastroenterology - Endoscopy at Hue University of Medicine and Pharmacy Hospital from April 1st, 2020 to March 30th, 2021. Methods: Cross-sectional, retrospective description. Results: Study on 67 patients who were dianosiged as having colorectal polyps through endoscopy, in which, 48 patients underwent polypectomy and histopathology. The mean age is 55.8 ± 15.7 years old, the most common age group is ≥ 45 years old, male/female is 2/1. The time from symptoms onset to disease detection is usually 6 months to less than 1 year (37.4%). The common clinical symptoms: abdominal pain (83.6%), diarrhea (29.9 %), constipation (28.4%), dysentery syndrome (13.4%), bloody stools (31.3%). The position of polyps: anus (1.5%), rectum (47.8%), sigmoid colon (40.3%), descending colon (31.3%), transverse colon (22.4%), ascending colon (28.4) %), cecum (13.4%). The proportion of patients having ≥ 2 polyps (59.7%), 1 polyp (40.3%). Polyp sizes: 5 - &lt; 10 mm (50.7%), &lt; 5 mm (37.4%), ≥ 10 mm (11.9%). The percentage of sessile polyps is higher than that of pedunculated polyps at each locations. Histopathological types: adenomatous polyps (60.4%), hyperplastic polyps (20.8%), malignant polyps (4.2%). Polyps with dysplasia (64.6%), mild – grade dysplasia (56.3%), severe-grade dysplasia (8.3%). The differences were statistically significant between the grade of dysplasia and the polyp size groups, between the histopathology and the grade of dysplasia (p &lt; 0.05). Conclusions: Colorectal polyps are more common in patients ≥ 45 years old, male are much more of having than female. Abdominal pain, bloody stools are common symptoms. Common polyp phenotypes are sessile polyps, ≥ 2 polyps, 5 - &lt; 10 mm in size, mainly in the rectum. Adenomatous polyps are the most common histopathological type, with the high rate of dysplasia. Key words: clinical, endoscopy, histopathology, colorectal polyps.

Association of gallbladder diseases with risk of gastrointestinal polyps

BackgroundIt has not yet been determined whether gastroscopy and colonoscopy screening help patients with gallbladder diseases. We aim to retrospectively investigate the relationship between gallbladder diseases and gastrointestinal polyps in order to provide a theoretical basis for the early screening of gastrointestinal polyps in patients with gallbladder disease.MethodsThis is a retrospective cross-sectional study involving 1662 patients who underwent gastroscopy, colonoscopy, and abdominal ultrasound as part of their health check-up from January 2015 to July 2020. We also compared the patients with and without gallbladder diseases to determine the prevalence of gastrointestinal polyps.ResultsPatients with gallbladder polyps had greater odds of having colorectal polyps (adjusted odds ratio (OR)=1.77, 95% confidence interval [Cl]: 1.23 to 2.54, p=0.002) and gastric plus colorectal polyps (adjusted OR=2.94, 95%Cl: 1.62 to 5.32, p<0.001) than those without. Patients with multiple gallbladder polyps had greater odds of having colorectal polyps (adjusted OR=2.33, 95% CI: 1.33 to 4.07, p=0.003) and gastric plus colorectal polyps (adjusted OR=3.95, 95% CI: 1.72 to 9.11, p=0.001), and patients with gallbladder polyps had greater odds of having left-colon polyps (adjusted OR=1.90, 95% CI: 1.25 to 2.88, p=0.003) and colorectal adenoma (adjusted OR=1.78, 95% CI: 1.19 to 2.66, p=0.005). We also noted that women with gallbladder polyps had a higher prevalence of colorectal polyps (OR=2.13, 95% CI: 1.20 to 3.77, p=0.010) and gastric plus colorectal polyps (OR=3.69, 95% CI: 1.58 to 8.62, p=0.003). However, no positive correlation was observed between gallbladder stones and gastrointestinal polyps.ConclusionsGallbladder polyps are significant indicators of colorectal and gastric plus colorectal polyps. Hence, gastroscopy and colonoscopy screening should be performed for patients with gallbladder polyps, particularly female patients and those with multiple gallbladder polyps.

Clinical, Endoscopic, Histopathological Characteristics Of Colorectal Polyps In Adults At Gastroenterology – Endoscopy Center, Hue University Of Medicine and Pharmacy Hospital

Background: Colorectal polyps are relatively common diseases in the group of lower gastrointestinal tract diseases. The prevalence of colorectal polyps ranges from 20 to 50%. Polyps are formed due to excessive hyperplasia of the mucosa and the malignancy rate of colorectal polyps is higher than other sites. Target: Describe some clinical, endoscopy and histopathology characteristics. Subjects: The patients aged 16 years old and older who were diagnosed colon polyps at the Center for Gastroenterology - Endoscopy at Hue University of Medicine and Pharmacy Hospital from April 1st, 2020 to April 30th, 2021. Methods: Crosssectional, retrospective description. Results: The mean age was 55.8 ± 15.7 years old, the most common age was ≥ 45 years old, male/female was 2/1. The common clinical symptoms: abdominal pain (83.6%), diarrhea (29.9%), constipation (28.4%), dysentery syndrome (13.4%), bloody stools (31.3%). The position of polyps: anus (1.5%), rectum (47.8%), sigmoid colon (40.3%), descending colon (31.3%), transverse colon (22.4%), ascending colon (28.4)%), cecum (13.4%). The proportion of patients ≥ 2 polyps (59.7%), 1 polyp (40.3%). Polyp sizes: 5 - &lt; 10 mm (50.7%), &lt; 5 mm (37.4%), ≥ 10 mm (11.9%). The percentage of sessile polyps was higher than that of pedunculated polyps at each locations. Histopathological types: adenomatous polyps (60.4%), hyperplastic polyps (35.4%), malignant polyps (4.2%). Polyps with dysplasia (64.6%), mild - grade dysplasia (56.3%), severe-grade dysplasia (8.3%). The differences were statistically significant between the grade of dysplasia and the polyp size groups, between the histopathology and the grade of dysplasia (p &lt; 0.05). Conclusions: Colorectal polyps are more common in patients ≥ 45 years old, male are much more than female. Abdominal pain, bloody stools are common symptoms. Common polyp phenotypes are sessile polyps, ≥ 2 polyps, 5 - &lt; 10 mm in size, mainly in the rectum. Adenomatous polyps are the most common histopathological type, with the high rate of dysplasia Key words: clinical, endoscopy, histopathology, colorectal polyps

Association of Meat Subtypes With Colorectal Polyp Prevalence: Finding From the Lanxi Pre-colorectal Cancer Cohort in China.

BackgroundAlthough the detrimental effect of red meat on colorectal cancer (CRC) incidence has been extensively reported, no previous studies have comprehensively linked different meat subtypes with colorectal polyp occurrence. The aim was to assess the association of meat and subtypes with colorectal polyp prevalence for the high-risk CRC Chinese population. Besides, we also focused on the association according to sizes, subsites, and multiplicity of polyps.MethodsHigh-risk CRC patients aged 40–80 years were enrolled into the Lanxi Pre-colorectal Cancer Cohort (LP3C) between March 2018 and December 2019. Cross-sectional analyses were conducted by using the baseline data from LP3C. A validated food frequency questionnaire (FFQ) was employed to collect dietary information. Odds ratios (ORs) and 95% confidence intervals (95% CIs) of colorectal polyp prevalence were estimated by multivariate logistic regression.Results2,064 colorectal polyp cases were identified among 6,783 eligible participants in the survey of LP3C (March 2018 and December 2019). Total meat intake was positively related to rectum polyp prevalence (Pfor trend = 0.01) but was not linked to total colorectal polyps after multivariable adjustment. For meat subtypes, higher poultry consumption was significantly related to a higher polyp prevalence [ORQ4vs.Q1 (95% CI): 1.20 (1.02–1.42); Pfor trend = 0.03]. Processed red meat intake was linked to an increased small polyp prevalence (Pfor trend = 0.03) while unprocessed red meat had a relation with a higher rectum polyp prevalence (Pfor trend = 0.04). Furthermore, seafood intake had a significant association with a higher multiple polyp prevalence [ORQ4vs.Q1 (95% CI): 1.70 (1.31–2.21); Pfor trend < 0.001].ConclusionThe finding was that poultry meat consumption was related to a higher polyp prevalence. Besides, total meat consumption, processed and unprocessed red meat consumption, seafood consumption had a positive relation with certain polyp subtypes prevalence. Generally recommending reducing total meat consumption, including poultry, processed and unprocessed red meat, and seafood intake, may prevent colorectal polyps.

Detection of Colonic Polyps During Colonoscopy in a Tertiary Care Center of Nepal.

Colorectal cancer is the third leading cause of cancer death in the world. Most colon cancer develop from the polyps. Data on the prevalence of colorectal polyps in Nepal is lacking. The objective was to determine the prevalence of colorectal polyps, site of occurrence and adenomas among various age groups. All polyps after removal by polypectomy was sent for histopathological examination. Study was done in 1027 consecutive patients who underwent colonoscopy in the pre-specified time after excluding patients with colorectal cancer, Inflammatory Bowel Disease and polyposis syndromes. Among 1027 patients, the mean age was 45 years. 292 (28.43%) were below 40 years, whereas, 735 (71.57%) were above 40 years. Polyps were detected in 12.95% of overall patients and in 9.73% of patients over age 40. The most common location of polyps was rectum (46.62%). 43.61% were adenomatous polyps, 11.28% were hyperplastic polyps, 18.05% were juvenile polyps, 22.56% were inflammatory polyps and 1.50% were malignant adenocarcinoma. Polyp detection rate was 12.95%, whereas adenoma detection rate was 5.84%. 46.55% had advanced adenomas. A positive correlation between the size of polyp and adenomatous variety was found [Chi-square value ?2 = 8.42 (>3.841), p value <0.05]. Prevalence of adenomatous polyps was significantly higher above the age of 40 [Chi-square value ?2 = 11.53 (>3.841), p value<0.05]. Conclusions: The prevalence of polyp increases with age. With increasing age and size of polyp, the prevalence of adenomatous polyp increases significantly. One out of every eight people over 40 years had a colonic polyp.

Association of preserved vegetable consumption and prevalence of colorectal polyps: results from the Lanxi Pre-colorectal Cancer Cohort (LP3C).

Although fresh vegetable consumption has been linked with a lower risk of colorectal polyps, a precursor lesion for colorectal cancer (CRC), the association between preserved vegetable consumption and colorectal polyps is unknown. We aimed to assess the association of preserved vegetable intake with the prevalence of colorectal polyps with the consideration of subsites, sizes and multiplicity of polyps. We analyzed the cross-sectional data from 40-80 years Chinese at a high risk of CRC from the Lanxi Pre-colorectal Cancer Cohort (LP3C) baseline survey, which was conducted between March 2018 and December 2019. Dietary information was obtained via a validated food frequency questionnaire. Multivariate logistic regression was employed to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of preserved vegetable consumption and the prevalence of colorectal polyps. Of 6783 eligible participants in 2018-2019 survey of LP3C, 2064 prevalent colorectal polyp cases were identified. In the multivariable-adjusted model, preserved vegetable consumption was positively associated with the prevalence of colorectal polyps (OR for fourth vs. first quartile: 1.18; 95% CI 1.01-1.36; P trend = 0.02). The similar association was also detected for small polyps [ORQ4 vs Q1 (95% CI): 1.17 (1.00-1.37); P trend = 0.03]. The similar trend was detected for multiple polyps [OR Q4 vs Q1 (95% CI):1.27 (0.98-1.64); P trend = 0.04], proximal colon polyps [ORQ4 vs Q1 (95% CI): 1.12 (0.90-1.38); P trend = 0.07], and single polyp [ORQ4 vs Q1 (95% CI) for 1.15 (0.98-1.35); P trend = 0.06]. No significant association was observed for distal colon [ORQ4 vs Q1 (95% CI) 1.19 (0.98-1.45); P trend = 0.09]. Replacing one serving per day of preserved vegetables with fresh vegetables was related to 20%, 23%, and 37% lower prevalence of overall, small, and multiple polyps, respectively. Preserved vegetable consumption was associated with a higher prevalence of colorectal polyps in a Chinese population at a high risk of CRC. Replacing preserved vegetables with fresh vegetables may be conducive to lower prevalent colorectal polyps.

Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly.

Colorectal polyps are precursor lesions of colorectal cancer and are known to be associated with obesity, low physical activity, and unhealthy behavior. This cross-sectional study analyzed the prevalence of colorectal polyps based on cardiorespiratory fitness (CRF), muscle strength, and health behavior in older adults. Participants were asymptomatic and included 1024 men and 472 women aged 65–80 years who visited the health care center. Colonoscopy was performed under conscious sedation, and cardiorespiratory fitness was measured as the maximum oxygen uptake using gas analysis. Muscle strength was determined using isokinetic equipment, and physical activity, alcohol consumption, and smoking status were investigated using questionnaires. Waist circumference was measured at the thickest part of the middle of the abdomen. Logistic regression analysis was used to calculate the prevalence of colorectal polyps using odds ratios (ORs) based on the variables. The incidence of colorectal polyps was 65.2% in men and 48.5% in women. The ORs of colorectal polyps for obesity were 1.151 (95% confidence interval [CI], 1.010–2.291) and 1.178 (95% CI, 1.015–2.612) in men and women, respectively. The OR for colorectal polyps in male current smokers was 1.884. The ORs for low CRF were 1.985 and 1.841 in men and women, respectively, compared with high CRF. The prevalence of polyps increased with low muscle strength (men’s OR 1.343 women’s OR 1.440) and physical activity in both men (OR 1.693) and women (OR 1.861). In conclusion, lower CRF and muscle strength were associated with an increased prevalence of colorectal polyps in men and women. In both sexes, high waist circumference and low physical activity increased the prevalence of colorectal polyps.

Prevalence of Colorectal Polyps in Patients with Chronic Hepatitis C Virus Infection in a Multi-Ethnic Hospital Population

Prevalence of Colorectal Polyps in Patients with Chronic Hepatitis C Virus Infection in a Multi-Ethnic Hospital Population

Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients

BackgroundColitis is generally considered a risk factor for colon neoplasia. However, not all types of colitis seem to have equal neoplastic transformation potential.AimTo determine the prevalence of colorectal polyps in a predominantly African American population with inflammatory bowel disease (IBD) and Non-IBD/Non-Infectious Colitis (NIC).MethodsWe retrospectively evaluated medical records of 1060 patients previously identified with colitis at Howard University Hospital, based on ICD-10 code. Among these, 485 patients were included in the study: 70 IBD and 415 NIC based on a thorough review of colonoscopy, pathology and clinical reports. Logistic regression analysis was applied to estimate the risk of polyps in patients with IBD compared to those with NIC after adjusting for age and sex. A subgroup analysis within the IBD group was performed.ResultsOf the 485 patients, 415 were NIC and 70 were IBD. Seventy-three percent of the NIC patients and 81% of the IBD patients were African Americans. Forty six percent of IBD and 41% of NIC cases were male. IBD patients were younger than NIC patients (median age of 38 years vs. 50, P < 0.001). The prevalence of all types of polyps was 15.7 and 8.2% in the IBD and NIC groups, respectively (P = 0.045). Among patients with polyps, the prevalence of inflammatory polyps was higher in the IBD group (55%) compared to the NIC group (12%). After adjusting for age, sex and race, odds ratio of inflammatory polyps in IBD patients was 6.0 (P = 0.016). Adenoma prevalence was 4.3% (3/70) in IBD patients and 3.9% (16/415) in the NIC patients (p = 0.75). The anatomic distribution of lesions and colitis shows that polyps occur predominantly in the colitis field regardless of colitis type. More polyps were present in the ulcerative colitis patients when compared to Crohn’s disease patients (27% vs. 5%, P < 0.001) within the IBD group.ConclusionOur study shows that inflammatory polyps are more common in IBD patients when compared to NIC patients. Most polyps were in the same location as the colitis.

Tu1505 THE PREVALENCE OF COLONIC POLYPS AND COLORECTAL CANCER IN PATIENTS WITH GASTRIC NEOPLASM: A SYSTEMATIC REVIEW AND META-ANALYSIS

Gastric adenomas are neoplastic with similar microscopic findings to those seen in colonic adenomas. Around 8-59% of gastric adenomas are associated with synchronous gastric carcinoma and hence repeat upper endoscopic surveillance after one year is usually recommended. On the other hand, the data has been scarce and inconsistent with regards to their association with colonic polyps and colorectal cancer. We aimed to analyze the previously published literature evaluating the association between gastric neoplasm and colonic polyps and colorectal cancer. We conducted a systematic literature search in PubMed, MEDLINE, EMBASE, and Cochrane databases from inception through November 2019 to identify studies evaluating the association between gastric adenomas or gastric neoplasms and colonic polyps, advanced adenomas, and colorectal cancer. Gastric neoplasm was universally defined in these studies as either malignancy or adenoma. Studies were examined, and relevant data was extracted and analyzed using Comprehensive Meta-Analysis (CMA), version 3 software. A random-effect meta-analysis approach was used to pool the data and an odds ratio (OR) was calculated for the overall effect estimate. A total of 134,317 patients from seven studies were identified and included in our analysis. The pooled OR for colonic polyps among patients with gastric neoplasm was 1.958 (95% CI:1.511-2.538; p=0.0001) compared to controls with modest heterogeneity (I2 =21.025%). (Fig 1a) Similarly, the pooled OR for advanced colonic adenomas in patients with gastric neoplasm was 2.129 (95% CI: 1.582–2.866; p=0.0001) compared to controls. (Fig 1b)Individuals with gastric neoplasm had an OR of 4.71 (95% CI: 1.296–17.139; p=0.019) for having synchronous colonic adenocarcinoma compared to controls. (Fig 1c)A subgroup analysis including only patients with gastric adenoma found an OR of 1.79 (95% CI: 1.341-2.403; P=0.0001) for having associated colonic polyps compared to controls. (Fig 2) No publication bias was found using Egger’s regression intercept. Our study findings indicate that the prevalence of colorectal polyps, advanced adenomas, and adenocarcinoma is significantly higher in patients with gastric adenomas and/or gastric malignancy compared to the general population. As such, screening colonoscopy may be justified in these patients following the diagnosis of gastric neoplasm for early detection and timely management of colonic neoplasia, particularly for patients over the age of 50 years.Fig 2Forrest plot, the pooled odds ratio evaluating the association between gastric adenoma and colonic polyps.View Large Image Figure ViewerDownload Hi-res image Download (PPT)