Introduction: Colorectal cancer (CRC) is a major cause of morbidity and mortality in Western countries and also in Japan. Colonoscopy is associated with a reduced incidence of CRC, and colonoscopic removal of adenomatous polyps results in the prevention of death from CRC. Endoscopic polypectomy carries a definite risk for complications, such as bleeding or perforation. Recently, the high safety and efficacy of cold snare polypectomy (CSP) has been reported, however, the evaluation of factors associated with safety and efficacy of CSP is deficit. The aim of this study is to elucidate the predictive factors of complications and complete histological eradication of polyp. Methods: We retrospectively reviewed the colonoscopic database of patients who underwent CSP between December 2013 to November 2014 in terms of patient's characteristics, location, size, macroscopic appearance of each colorectal polyp, narrow band imaging with magnification (NBI-M), and endoscopist's experience. CSP were performed by 21 endoscopists consisted of 8 experts and 13 trainee. CSP were indicated for polyps presenting at colonoscopy with at least < 10-mm polyp. Univariate and multivariate analysis were performed to reveal the predictive factors associated with complications and complete histological eradication. Results: A total of 399 polyps in 216 patients without antithrombotics were removed. Of these, 355 polyps (89%) were ≤ 5 mm and 175 polyps (44%) were protruding lesions. Failure of tissue retrieval was noted in 3% of resected polyps. There was no intramucosal carcinoma. Colonoscopy with NBI-M was performed for 75 polyps (19%). Although immediate bleeding or hematochezia after procedure occurred in 30 polyps (7.5%) of 21 patients (9.7%), no delayed bleeding or perforation was observed. At multivariate analysis, protruded lesion was an independent risk factor associated with post-polypectomy bleeding (odds ratio [OR] 2.5; 95%CI 1.12-5.56). The overall rate of complete histological polyp eradication was obtained in 139 polyps (35%). Multivariate analysis elucidated that the observation of the polyp with NBI-M was an independent predictor associated with complete histological eradication (OR 2.27; 95%CI 1.36-3.78). Conclusion: CSP is a safe and effective technique for small and diminutive polyps. Macroscopic protruding appearance of polyp is a risk factor for post-polypectomy bleeding. A higher rate of complete histological eradication with CSP can be achieved by colonoscopy with NBI-M than with white-light imaging.
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