Introduction: In immunocompromised individuals, the normally benign opportunistic fungal infection mucormycosis can manifest as fulminant systemic disease. Gastrointestinal mucor infection is extremely rare, and can present as non-specific symptoms such as abdominal discomfort, intestinal obstruction, or rectal bleeding. Without aggressive treatment, mucor infection carries a high mortality especially in the immunocompromised population. A 76-year-old female with a history of atrial fibrillation, recently started on systemic steroids for suspected amiodarone-induced pulmonary fibrosis, presented with complaints of abdominal pain, diarrhea, and rectal bleeding. A colonoscopy was performed and revealed multiple near circumferential ulcers affecting approximately 5 cm of colon located 10-15 cm proximally to the rectum. Biopsies of the ulcers revealed invasive mucormycosis. Steroids were discontinued and she was initiated on amphotericin B at 5mg/kg daily, which was later increased to 10 mg/kg daily due to an poor clinical response. Surgical intervention with colonic resection of the invaded segment, in addition to systemic antifungal therapy, was presented as treatment to the patient. Despite these recommendations, the patient refused surgical intervention due to fear of surgical complication. Choosing treatment with antifungal therapy alone, she continued with gradual hemodynamic decline, eventually requiring presser support. She soon developed pancytopenia and later developed a co-infection with Staph aureus pneumonia with significant pleural effusions. She ultimately died from progression of her infections within 2 weeks of the initial onset of symptoms. Mucormycosis is a rare etiology of colitis with very few reported cases of patient survival without surgical resection of the infected tissue. Similar to our patient, most reported cases result in mortality with antimicrobial treatment alone. Quick recognition of infection of the gastrointestinal tract by mucormycosis in immunocompromised individuals is essential, as prognosis depends on speed of diagnosis and debridement of the infected body area.Figure 1: Near circumferential ulcerated colonic mucosa in the rectum.