Secondaryreconstruction after failedesophageal surgeryremains a challenging surgical problem. In circumstances when neither the stomach nor the small or large bowel is available or adequate as an esophageal replacement, skin or musculocutaneous flaps should be considered. We report a case of salvage esophageal reconstruction using a prefabricated muscle flap in combination with pedicled jejunum in a staged fashion that highlights some of the management issues in addressing this difficult clinical situation. Clinical Summary A 50-year-old man with a history of Barrett’s esophagus was found to have invasive adenocarcinoma in the distal third of his esophagus during surveillance endoscopy. He underwent en bloc esophagogastrectomy with 3-field lymph node dissection. On the fourth postoperative day ischemic necrosis of the gastric conduit developed, and the distal third of the conduit was resected. The left colic artery was sclerotic, so an isoperistaltic right colon interposition graft was used to connect the cervical esophagus to the gastric conduit remnant. Two weeks later, a right-sided empyema developed, and the colon interposition graft was found to be infarcted. The patient underwent decortication of the right lung and excision of the necrotic colon graft, and a cervical esophagostomy was created. Five months after the initial operation, the patient was referred to Massachusetts General Hospital/Harvard Medical School for an opinion on the options for esophageal reconstruction. Esophageal reconstruction was performed using a delayed, prelaminated, and tubularized pectoralis major muscle flap and pedicled jejunal interposition graft in a series of 3 staged procedures. Thefirst procedure was prelamination and delay of a right-sided pectoralis major muscle flap. A large fasciocutaneous flap was elevated to expose the entire pectoralis muscle. After the superior and lateral vascular bundles entering the pectoralis major were divided, a splitthickness skin graft from the right thigh was sutured over the entire muscle flap. The fasciocutaneous flap was then returned to the chest wall to cover the entire construct. One month later the pectoralis major flap was elevated, and the thoracoacromial vessels were divided, leaving the flap based on the internal thoracic artery perforators medially. The flap was tubularized by rolling it to create a skin-lined tube 22 cm in length. The proximal end of the tube was anastomosed to the distal cervical esophagus. The fasciocutaneous chest wall flap was advanced to cover the neoesophagus. At the distal end of the neoesophagus, the tube was sutured to the abdominal wall skin. This allowed salivary secretions to drain into an ostomy appliance affixed to the abdominal wall. Two months later a laparotomy was performed, and a Roux-en-Y jejunal segment was anastomosed to the distal end of the tubularized pectoralis major muscle flap (Figure 1). On postoperative day 7, the patient underwent a barium swallow that showed no anastomotic leaks with contrast flowing rapidly to the jejunum. The patient was able to discontinue enteral tube feedings and now is able to obtain 100% of his nutrition orally. Figure 2 shows the patient at the time of discharge from the hospital after the completed reconstruction.