Abstract Aims To report on the outcomes of patients undergoing colon capsule endoscopy (CCE) in Scotland (ScotCap) using a national CCE registry. Methods Patients undergoing CCE in NHS Scotland between August 1st, 2021 and August 1st, 2022 were included in this study. Patients were vetted to undergo CCE by clinicians in 5 NHS Scotland health boards. Patient data were collected prospectively by an eHealth system managing CCE referral and report sign off. CCE procedure data were collected by the ScotCap managed service carrying out CCE procedures. Data from both sources were compiled in the national CCE registry managed by Public Health Scotland. Results 1290 patients were included in this study. The median age of patients was 59 years and 58.5% of patients were female. A haemoglobin count was available for 1062 (82.3%) patients and the mean value was 139g/L. Faecal immunochemical test results were available for 1105 (85.7%) patients and of those with a test result, 903 (81.7%) had a result ≥10 µgHb/g. The rate of complete test, adequate bowel preparation and successful test (complete test with adequate bowel preparation) was 66.4%, 63.8% and 62.1%, respectively. Following CCE, 41.2%, 36.7%, 20.9% and 1.1% of patients required no further test, colonoscopy, flexible sigmoidoscopy and gastroscopy, respectively. One patient was reported to have experienced capsule retention with obstruction. Conclusions These are the first reported outcomes from the Scottish national CCE registry, and the largest reported series of CCE to date, which demonstrate a significant proportion of patients avoid colonoscopy when CCE is deployed nationally.