This article describes the distinguished career of Andrew M. Sessler, the visionary former director of the Lawrence Berkeley National Laboratory (LBNL), one of the most influential accelerator physicists, and a strong, dedicated human-rights activist. Andy died on 17 April 2014 from cancer at age 85. He grew up in New York City, and attended Harvard (BA in Mathematics, 1949) and then Columbia (PhD in Physics, 1953.) After an NSF postdoc at Cornell with Hans Bethe and a stint on the faculty at the Ohio State University in 1954–59, he joined the Lawrence Radiation Laboratory (now LBNL) in 1959, and spent the remainder of his career there. Although Andy left his mark on several areas of physics, including nuclear structure theory, elementary-particle physics, and many-body problems, his lasting and most important contributions came from his efforts in accelerator physics and engineering, to which he devoted most of his life's work. In collaboration with his colleagues of the legendary Midwestern Universities Research Association, he developed theories for the RF acceleration process and the collective instability phenomena, helping to realize the colliding-beam accelerators with which most of the high-energy-physics discoveries of the last few decades have been made. His work in connection with the free-electron-laser (FEL) amplifier for high-power microwave generation constructed at the Lawrence Livermore National Laboratory anticipated the optical-guiding and the self-amplified spontaneous-emission principles, upon which the success of the X-ray FELs as the fourth-generation light sources is based. Throughout his career Andy made major contributions to issues related to the impact of science and technology on society. He helped usher in a new era of research on energy efficiency and sustainable-energy technology and was instrumental in building the research agendas in those areas for the Atomic Energy Commission (AEC) and later the Department of Energy. With a lifelong interest in promoting the human rights of scientists, Andy was instrumental in initiating the American Physical Society's Committee on International Freedom of Scientists and in raising funds to endow the APS Andrei Sakharov Prize. He and Moishe Pripstein cofounded Scientists for Sakharov, Orlov, and Sharansky; the group's protests along with those of other groups led to the release of the three Soviet dissidents. More importantly, Andy's voice and example became a major force in helping call the world's attention to the plight of scientists trapped in places where their human rights and their ability to do science were severely compromised. Andy received many honors, including the AEC's Ernest Orlando Lawrence Award in 1970, the APS's Dwight Nicholson Medal in 1994, and the Enrico Fermi Award from the US Department of Energy in 2014.