The research intends to find the internal influence mechanism of interpersonal relationship on college students' mental health. College students have many mental health problems, which can easily lead to extreme events. It is of great research value to explore the relationship among interpersonal relationship, safety awareness, college planning, and mental health. GHQ, WHOQOL-BREF, SWBS-CC, LSIB, and TSCS scales were used, revised questionnaire for cluster sampling of college students, 1661 valid samples. SPSS 26.0 and PROCESS V4.1 were used for analysis, and nonparametric Bootstrap method was used to test the significance level of the mediating effect. There are significant differences in interpersonal relationship, safety awareness, and college planning between high mental health group and low mental health group. There are differences in safety awareness between genders. There is a positive correlation among interpersonal relationship, safety awareness, college planning, and mental health. Interpersonal relationship has a positive predictive effect on mental health. There are three mediating pathways of interpersonal relationship on mental health: independent mediating effect pathway of safety awareness, independent mediating effect pathway of college planning, and chain mediating effect pathway through safety awareness and college planning. This study reveals the Influence mechanism of interpersonal relationships on college students' mental health. The relationship between interpersonal relationship and mental health is affected by the multiple mediating effects of safety awareness and college planning. It provides a new perspective for preventing and intervening mental health problems. College students' personality has plasticity, which can be interfered by mediating mechanism. The present findings could help college students actively participate in interpersonal communication, improve safety awareness, and make a good college planning, so as to enhance the mental health level of college students.
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