This article is the result of a qualitative study that aimed to understand how the lives of people living with HIV (PLHIV) were reorganized after at least one year of living with the disease. For this purpose, interviews were conducted with some generating questions preceded by characterization of the subjects. The methodology chosen for organizing the data was the Collective Subject Discourse (CSD), having as theoretical reference psychoanalysis and scientific productions related to the theme. The result refers to a thematic axis named “Subjective experience and adaptation from the disease”, which constituted three collective subject discourses (CSD), these were named by the central ideas (ICS): (1) resignification from the disease, (2) biopsychological repercussions of the diagnosis; and (3) silence with self-protection. It was concluded that there is not just one way to reorganize life from the diagnosis, but it is correct to state that the stigma of the disease has a direct influence on all subjects.