The informatization construction of college English Flipped classroom, as a means of teaching, especially an effective application of language teaching, is worth our repeated use. After the exam oriented English learning in the early and high school stages, the majority of students passively accept English learning and lack initiative. After entering the university, their requirements for English learning will also be improved accordingly, hoping that learning is a relaxed and pleasant form, and Flipped classroom teaching plays such a role in this process. According to the author's visit to some college students, Flipped classroom is a popular teaching mode in college English teaching, and students are more willing to carry out autonomous learning and improve learning efficiency through this flipped mode. Through this article, we know the importance and practicality of the informatization construction of Flipped classroom in college English teaching, which helps us to find the best way to improve and ultimately achieve better teaching goals.