Stroke remains a leading cause of mortality and long-term disability worldwide, with variable recovery trajectories posing substantial challenges in anticipating post-event care and rehabilitation planning. In response, we established the NeuralCup consortium to address these challenges by benchmarking predictive models of stroke outcome through a collaborative, data-driven approach. This study presents the findings of 15 participating teams worldwide who used a comprehensive dataset including clinical and imaging data, to identify and compare predictors of motor, cognitive, and emotional outcomes one-year post-stroke. Analyses integrated traditional and novel approaches, including machine learning algorithms to discover 'optimal recipes' for predicting each domain. The differences in these 'optimal recipes' reflect distinct brain mechanisms in response to different tasks. Key predictors across all domains included lesion characteristics, T1-weighted MRI sequences, and demographic factors. Additionally, the integration of FLAIR imaging and white matter tract analysis significantly improved the prediction of cognitive and motor outcomes, respectively. These findings support a multifaceted approach to stroke outcome prediction, underscoring the potential of collaborative data science to develop personalized care strategies that enhance recovery and quality of life for stroke survivors.
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