Biomedical Research Collaboration Research Articles

It May Not Be So Typical: Distinguishing Frontotemporal Dementia From Behavioral Variant Alzheimer's Disease.

The Banner Alzheimer's Institute Case Conference is a weekly event in which physicians and staff discuss challenging and/or teaching cases of patients seen in clinical settings. These conferences are attended by a multidisciplinary group that includes Banner Alzheimer's Institute dementia specialists, community physicians (internal medicine, family medicine, and radiology), neuropsychologists, physician assistants, nurse practitioners, social workers, medical students, residents, and fellows. The Banner Alzheimer's Institute is located in Phoenix, Arizona, and it has an ambitious mission: to end Alzheimer's disease without losing a generation, set a new standard of care for patients and families, and forge a model of collaboration in biomedical research. The Institute provides high-level care and treatment for patients affected by Alzheimer's disease, dementia, and related disorders. In addition, the Institute offers extensive support services for families and many unique and rewarding research opportunities.

Analysis of ethics dumping and proposed solutions in the field of biomedical research in China.

As international academic exchanges and cooperation deepen, China has actively engaged in international biomedical research collaboration and achieved significant success. However, these accomplishments have been accompanied by ethical controversies and issues, with ethics dumping being a recurrently discussed focus among scholars. This paper reviews ethics dumping incidents in China's biomedical research field and analyzes the underlying causes to answer why China is often susceptible to ethics dumping. We argue that the primary reasons include weak ethical awareness among some researchers, an oversimplified research evaluation system, gaps in relevant ethics governance and oversight mechanisms, and limited capabilities of certain ethics committees. To address these issues, we propose five ethics governance recommendations: establishing refined ethics committees at various levels and types; advancing theoretical and practical research on science and technology ethics governance; strengthening legislation and regulation related to emerging science and technology; emphasizing self-regulation and capacity building of research institutions; and providing special protection and healthcare for victims of ethics dumping. The aim is to enhance China's research supervision system and prevent similar ethics dumping incidents from recurring.

The Danish-American Research Exchange (DARE): a cross-sectional study of a binational research education program

BackgroundMost medical educational programs emphasize clinical observation or clinical skill acquisition, fewer focus upon research. The Danish-American Research Exchange (DARE) program, sponsored by the Lundbeck Foundation, is unique in that the medical student initiates biomedical research collaboration between Danish and US medical institutions. To achieve this, Danish medical students (DARE students) conduct binational mentored research projects while based in the United States for 10 months. In addition, DARE students are introduced to interdisciplinary thinking about how to develop ultra-low-cost healthcare interventions through the ‘$10 Challenge’.MethodsWe conducted a cross-sectional study of DARE alumni over five consecutive years (2015–2020, n = 24). Research metrics included completion of a research project, primary authorship, and co-authorship of publications. The number of publications, prior to and after the DARE program were enumerated. For the first four cohorts, graduation from medical school and acceptance or intention to enter a joint MD-PhD program also were assessed. Two focus groups were conducted using constructivist grounded theory. Discussions were transcribed, redacted, and coded using Dedoose software.ResultsDARE Medical students were 31.2 years (range 24–35), the majority were women (67%;16/24). The majority (17/24;71%) completed a first author publication in a peer-reviewed journal with a median of 3.9 per DARE alumnus. DARE alumnus reported increased proficiency in biostatistics, epidemiology, coding and public speaking as well as stronger research qualities in creativity, critical thinking, comfort in approaching scientist in both the US and Denmark (p < 0.001 for all). Qualitative key themes included: increased confidence, a deepening of research inquiry and linkage to a research network.ConclusionsPreliminarily, this study suggests that medical students can initiate binational collaboration in medicine. Benefits include research productivity, intention to pursue academic medical careers, as well as positive impacts on motivation. This medical student-initiated research model lays the groundwork for using this model across other country pairs to promote binational collaboration.

Searching for a Cure: The Role of a Project Scaffolding Intervention In Scientific Collaborations

We investigate the use of formal interventions in early-stage discovery collaborations focused on curing devastating diseases. To advance their objectives, these collaborations must overcome profound differences in members’ specialized knowledge, despite having limited familiarity and prior histories of collaboration with one another. We conducted a field quasi-experiment using 26 biomedical research collaborations across the US beginning to work on treatments or cures for human diseases. We provided and tested the efficacy of a formal scaffolding intervention, focused on tentative problem solving and provisional planning. Results show that using this intervention allowed collaborations to integrate members’ disparate and diverse expertise into innovative research projects, which led to increased productivity. The effect of the intervention was mediated by the extent to which collaborators were able to align and coordinate with one another to complete project tasks. Elements of transactive memory (i.e., knowing who knows what) and nascent creative efficacy did not mediate this effect.

The Dockstore: enhancing a community platform for sharing reproducible and accessible computational protocols.

Dockstore (https://dockstore.org/) is an open source platform for publishing, sharing, and finding bioinformatics tools and workflows. The platform has facilitated large-scale biomedical research collaborations by using cloud technologies to increase the Findability, Accessibility, Interoperability and Reusability (FAIR) of computational resources, thereby promoting the reproducibility of complex bioinformatics analyses. Dockstore supports a variety of source repositories, analysis frameworks, and language technologies to provide a seamless publishing platform for authors to create a centralized catalogue of scientific software. The ready-to-use packaging of hundreds of tools and workflows, combined with the implementation of interoperability standards, enables users to launch analyses across multiple environments. Dockstore is widely used, more than twenty-five high-profile organizations share analysis collections through the platform in a variety of workflow languages, including the Broad Institute's GATK best practice and COVID-19 workflows (WDL), nf-core workflows (Nextflow), the Intergalactic Workflow Commission tools (Galaxy), and workflows from Seven Bridges (CWL) to highlight just a few. Here we describe the improvements made over the last four years, including the expansion of system integrations supporting authors, the addition of collaboration features and analysis platform integrations supporting users, and other enhancements that improve the overall scientific reproducibility of Dockstore content.

Twenty Years of Leading the Way among Cohort Studies in Community-Driven Outreach and Engagement: Jackson State University/Jackson Heart Study.

Background: History has recorded the tremendous concerns and apprehension expressed by African Americans about participating in research studies. This review enumerates the collaborative techniques that were utilized by the Jackson State University (JSU) Jackson Heart Study (JHS) community-focused team to facilitate recruitment and retention of the JHS cohort and to implement health education and health promotion in the JHS communities. Methods: This review describes the evolution of the JSU JHS community initiatives, an innovative community-driven operation, during the period 1999–2018. Results: JSU JHS community-focused investigators published approximately 20 manuscripts, including community-led research and publications with community lead authors and co-authors, research and publications in collaboration with other JHS staff, through other JSU-funded projects. The JSU JHS community-focused unit also initiated the JHS Community Training Activities, developed the Community Health Advisory Network (CHAN), and trained and certified 137 Community Health Advisors. In addition, the JSU JHS community-focused unit developed the Collaborative Community Science Model (CCSM) that symbolized its approach to community engagement and outreach, and a Trust Scale for ascertaining African Americans’ willingness to engage in biomedical research collaborations. Conclusion: This review offers educators, public health professionals, and research investigators a useful starting point for the development, selection, or improvement of techniques to motivate, inspire, and engage community residents in a community–academia partnership that yielded maximum benefits in the areas of health education, health promotion and interventions, and biomedical research. Substantial, meaningful community engagement is possible when prioritizing elimination of health disparities and long-term improvement in health care access in the target populations.

Promoting Interprofessional Collaboration in Biomedical Research

Promoting Interprofessional Collaboration in Biomedical Research

Beyond a Disease Registry: An Integrated Virtual Environment for Adrenal Cancer Research

Many biomedical research collaborations are focused on the establishment of web-based databases that capture phenotypic and in some cases genotypic information, targeted to specific diseases – so called disease registries. Such resources are often used for clinical matchmaking and allow information on patients and patient disorders to be shared by clinicians with wider biomedical research communities outside of a given hospital setting, and potentially with patients and/or patient advisory groups. Whilst addressing aspects of clinical collaborations through making targeted biomedical data accessible - such registries are really only a starting point for what can be achieved to support research collaborations. In particular, registries should ideally be augmented with a portfolio of additional service offerings that facilitate secure research collaborations: bio-banking and bio-sample data tracking capabilities; support for feasibility analysis on clinical trials and studies; offer seamless data transfer to/from clinical trials; provide search and analytical capabilities in a user-driven research environment. Such a feature rich, Internet-based virtual research environment (VRE) has been established as part of the European Union funded ENS@T-CANCER (http://www.ensat-canser.eu) project that has a particular focus on supporting research into four primary types of adrenal tumors. This paper provides an overview of the ENS@T-CANCER VRE, outlining its core capabilities and how it has galvanized previously and largely fragmented, country-specific database and registry efforts. To illustrate the utility of the ENS@T-CANCER VRE for clinical trials we focus on the full 4-phase, international, multi-centre Prospective Monoamine Tumor (PMT) clinical trial and its utilisation of capabilities provided by the VRE.

Does science need bioethicists? Ethics and science collaboration in biomedical research.

Biomedical research is an increasingly multidisciplinary activity bringing together a range of different academic fields and forms of expertise to investigate diseases that are increasingly understood to be complex and multifactorial. Recently the discipline of ethics has been starting to find a place in large-scale biomedical collaborations. In this article we draw from our experience of working with the Malaria Genomic Epidemiology Network (MalariaGEN) and other research projects to reflect upon the integration of ethics into biomedical research. We examine the way in which ethics input may be valuable to research, the forms it tends to take, and also the problems and limitations of such collaborations.

Computational approaches for predicting biomedical research collaborations.

Biomedical research is increasingly collaborative, and successful collaborations often produce high impact work. Computational approaches can be developed for automatically predicting biomedical research collaborations. Previous works of collaboration prediction mainly explored the topological structures of research collaboration networks, leaving out rich semantic information from the publications themselves. In this paper, we propose supervised machine learning approaches to predict research collaborations in the biomedical field. We explored both the semantic features extracted from author research interest profile and the author network topological features. We found that the most informative semantic features for author collaborations are related to research interest, including similarity of out-citing citations, similarity of abstracts. Of the four supervised machine learning models (naïve Bayes, naïve Bayes multinomial, SVMs, and logistic regression), the best performing model is logistic regression with an ROC ranging from 0.766 to 0.980 on different datasets. To our knowledge we are the first to study in depth how research interest and productivities can be used for collaboration prediction. Our approach is computationally efficient, scalable and yet simple to implement. The datasets of this study are available at https://github.com/qingzhanggithub/medline-collaboration-datasets.

From global bioethics to ethical governance of biomedical research collaborations

One of the features of advanced life sciences research in recent years has been its internationalisation, with countries such as China and South Korea considered ‘emerging biotech’ locations. As a result, cross-continental collaborations are becoming common generating moves towards ethical and legal standardisation under the rubric of ‘global bioethics’. Such a ‘global’, ‘Western’ or ‘universal’ bioethics has in turn been critiqued as an imposition upon resource-poor, non-Western or local medical settings. In this article, we propose that a different tack is necessary if we are to come to grips with the ethical challenges that inter-continental biomedical research collaborations generate. In particular we ask how national systems of ethical governance of life science research might cope with increasingly global research collaborations with a focus on Sino-European collaboration. We propose four ‘spheres’ – deliberation, regulation, oversight and interaction – as a helpful way to conceptualise national systems of ethical governance. Using a workshop-based mapping methodology (workshops held in Beijing, Shanghai, Changsha, Xian, Shenzen and London) we identified three specific ethical challenges arising from cross-continental research collaborations: (1) ambiguity as to which regulations are applicable; (2) lack of ethical review capacity not only among ethical review board members but also collaborating scientists; (3) already complex, researcher-research subject interaction is further complicated when many nationalities are involved.

Abstract ED05-02: The Clinical and Translational Science Award Program: Transdisciplinary teams in cancer prevention research

Abstract National CTSA Program The Clinical and Translational Science Awards (CTSA) program supports a national consortium of 60 medical research institutions that are transforming the way biomedical research is conducted. Its goals are to accelerate the translation of laboratory discoveries into treatments for patients, to engage communities in clinical research efforts, and to train a new generation of clinical and translational researchers. www.ctsacentral.org/ctsa-consortium Launched in 2006 by the National Institutes of Health (NIH), the CTSA program has enabled innovative research teams to speed discovery and advance science aimed at improving our nation's health. Led by NIH's National Center for Advancing Translational Sciences, the CTSA program encourages collaborative teams of investigators to tackle complex health and research challenges and then find ways to turn these discoveries into practical solutions for patients. These teams are already making progress across a broad range of diseases. Team Science The full complexities of the biological, technological and public health problems in cancer prevention are not effectively addressed by individual investigators working in isolation. It has been suggested that the challenges posed will require cross-disciplinary engagement and collaboration that extends to long term interactions among groups of investigators in an approach that has been termed team science. At UCLA, our Clinical and Translational Science Institute (CTSI) is the key to transforming our environment to establish transdisciplinary team science as our operating principle in clinical and translational investigation. CTSA Consortia Together, CTSAs are working on a national coordinated approach to recruit, educate, train and promote the development of clinical and translational investigators conducting research to improve human health. One example of this is the University of California Biomedical Research, Acceleration, Integration &amp; Development (UC BRAID). The five UC medical campus CTSAs, in collaboration with the UC Office of the President have identified system-wide collaboration in biomedical research as an opportunity to enhance clinical and translational research efforts. In response, they launched an initiative in 2010 to identify policy changes and areas of collaboration to accelerate biomedical research across the UC biomedical campuses. The UC BRAID program, is this effort to accelerate clinical and translational research. Working groups in 1) Biospecimen banking, 2) Contracting, 3) Drug and Devise Discovery and Development 4) Informatics, and 5) IRB harmonization have been developed to identify short- and long-term solutions to shared challenges. These groups have been working to identify policy changes, new infrastructure, or processes that will reduce the barriers to clinical and translational research. http://www.ucbraid.org/ Examples will be provided illustrating team science among investigators as well as institutional consortia that facilitate robust infrastructure for clinical and translational investigation. Citation Format: Steven M. Dubinett. The Clinical and Translational Science Award Program: Transdisciplinary teams in cancer prevention research. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr ED05-02.

Sectoral collaboration in biomedical research and development

This paper explores the role of sectors in scientific research and development networks by drawing on bibliometric analyses and innovation systems and triple helix literatures. I conducted a bibliometric study of Vancouver Canada's worldwide infection and immunity network and examined network structure through sociograms, social network metrics, as well as relational contingency table and ANOVA network analyses. Universities are the key network sector followed by hospitals and government organisations. The private sector plays a weak role. Most sectors show a preference for collaborating within, as opposed to across, sectors. This trend is most pronounced in hospitals and least pronounced among firms. Hospitals and universities collaborate well above statistical expectations. I discuss the implications of these findings for future science policy and studies of research and development networks.

A study in the growth of international biomedical research collaboration in Korea

This article is a study about international scientific collaboration, specifically as it relates to the biotechnology sector in Korea. The Korean biotechnology sector is compared to other major centres for biotechnology in the world, and we give recommendations to improve it. The importance of international collaboration is stressed. This article lists the different types of international collaboration, and the current trends in the international scientific community. Then the focus is narrowed specifically to the biotechnology sector, where collaboration is examined in greater detail. Trends in the United States and the European Union are examined to give a greater context to the discussion. Within this comprehensive frame of reference, Korean biotechnology achievements are discussed, problems observed in Korean biotechnology are listed and possible solutions to these problems are given.

Semantic Web for Health Care and Life Sciences: a review of the state of the art

Semantic Web for Health Care and Life Sciences: a review of the state of the art

Building biomedical web communities using a semantically aware content management system

Web-based biomedical communities are becoming an increasingly popular vehicle for sharing information amongst researchers and are fast gaining an online presence. However, information organization and exchange in such communities is usually unstructured, rendering interoperability between communities difficult. Furthermore, specialized software to create such communities at low cost-targeted at the specific common information requirements of biomedical researchers-has been largely lacking. At the same time, a growing number of biological knowledge bases and biomedical resources are being structured for the Semantic Web. Several groups are creating reference ontologies for the biomedical domain, actively publishing controlled vocabularies and making data available in Resource Description Framework (RDF) language. We have developed the Science Collaboration Framework (SCF) as a reusable platform for advanced structured online collaboration in biomedical research that leverages these ontologies and RDF resources. SCF supports structured 'Web 2.0' style community discourse amongst researchers, makes heterogeneous data resources available to the collaborating scientist, captures the semantics of the relationship among the resources and structures discourse around the resources. The first instance of the SCF framework is being used to create an open-access online community for stem cell research-StemBook (http://www.stembook.org). We believe that such a framework is required to achieve optimal productivity and leveraging of resources in interdisciplinary scientific research. We expect it to be particularly beneficial in highly interdisciplinary areas, such as neurodegenerative disease and neurorepair research, as well as having broad utility across the natural sciences.

The Origins of the Anglo-American Research Alliance and the Incidence of Civilian Neuroses in Second World War Britain

From August 1940 until May 1941, Germany subjected Great Britain to air bombardments by night and day. Desmond Flower recalled how London shook as the first bombs hit the docks, while in early September 1940, nurse Frances Faviell described London's casualties as, “bodies, limbs, blood and flesh mingled with little hats, coats, and shoes”.1 Despite this onslaught and the ‘“Blind savagery” of night attacks’, The Times described a courageous dignity among the citizenry.2 Continuing this pattern in his private correspondence, the Edinburgh psychiatrist David Kennedy Henderson would write in the New Year to his American colleague, Adolf Meyer, that: In such times as these the potential neurotic or psychotic pulls himself together a bit, he wants to put on a face as good and as great as any other man, he rises to the occasion and in consequence consultation work and admission to hospital are rather less than in ordinary times.3 Such public and private sentiments were commonplace and echoed the personal, societal, and political need to appear courageous, as well as controlled, unified, and unwavering in morale.4 In various ways, it was a language of reassurance: one that comforted the British population at home while also heightening the confidence of her allies abroad that Britain would carry on. This rhetoric of fortitude was becoming one of the lifelines of Britain's national sovereignty.5 Scholars often discount the effects of such rhetoric on the production of science and the practice of medicine, yet such rhetoric is significant, especially when explored from outside the more traditional perspective of national history.6 This paper does that by emphasizing the connected context of biomedical science in Britain and North America during the early years of the Second World War. At the time of the blitz, physicians and scientists on both sides of the Atlantic began developing informal structures and institutions to support a transnational biomedical research collaboration for the combined defence of Anglo-America.7 As this biomedical collaboration formalized slowly within institutions and government directives, relations at times became problematic.8 One area where differences arose concerned questions about the causes and incidence of civilian neuroses in Britain. Were air raids, for instance, causing increases? The rhetoric of the times suggested they were not, but was that merely the consequence of social policy? In Britain by 1940, physicians, cradled in the experience of treating patients with neuroses during the First World War, and now acting as advisers to the Ministry of Health and the Ministry of Pensions, had crafted “a double-barrelled approach” to mental illness. This, according to Ben Shephard, treated real neurotics while discouraging civilian and military cases of war neuroses by suppressing “all mention of quasi-medical terms like ‘shell-shock’”, denying pensions for such cases, and making it “impossible for ‘neurosis’ to be used as grounds for getting discharged from the Army”.9 These policies, however, were not well understood by civilian scientists and physicians in the United States, who alleged that their collaborators were under-reporting the direct effects of the bombing on the civilian population. These differences exacted a toll by politicizing the transnational collaboration's aims, methods, and even its scientific conclusions. Nevertheless, the origins of this Anglo-American biomedical research alliance lay in a realm of assumed shared values, while the tensions of that assumption became inextricable from the joint endeavour in cooperation. The international context of the question of civilian neuroses in Britain, therefore, provides a site from which we can survey the resulting political tensions between government agencies and friends alike. This paper uses the case of this transnational collaboration to examine the limits of scientific objectivity in wartime Britain, while also calling attention to the ways this alliance helped to foster the transformation from the informal world of inter-war biomedicine to the structured government science found in Britain and North America in the post-war period.10

...and solicits US collaboration

Yu Peng, China's vice minister of health, has met with National Institutes of Health (NIH) director, Harold Varmus, in an effort to improve biomedical research collaboration between the two countries.

Local, Domestic and International Scientific Collaboration in Biomedical Research

Collaboration practices and partners vary greatly per scientific area and discipline and influence the scientific performance. Bibliometric indicators are used to analyse international, domestic and local collaboration in publications of Spanish authors in three Biomedical subfields: Neurosciences, Gastroenterology and Cardiovascular System as covered by theSCI database. Team size, visibility and basic-applied level of research were analysed according to collaboration scope. International collaboration was linked to higher visibility documents. Cluster analysis of the most productive authors and centres provides a description, of collaboration habits and actors in the three subfields. A positive correlation was found between productivity and international and domestic collaboration at the author level.

Sino-American collaboration in biomedical research and training: American and Chinese physiological societies look toward new horizons

ARTICLESSino-American collaboration in biomedical research and training: American and Chinese physiological societies look toward new horizonsCraig C. MalbonCraig C. MalbonPublished Online:01 Mar 1991https://doi.org/10.1152/ajpcell.1991.260.3.C670MoreSectionsPDF (757 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Download PDF FiguresReferencesRelatedInformation Cited ByRenal Medullary Oxidative Stress, Pressure-Natriuresis, and HypertensionHypertension, Vol. 52, No. 5Prediction of Clinical Response After Renal Angioplasty: Respective Value of Renal Doppler Sonography and ScintigraphyAmerican Journal of Roentgenology, Vol. 181, No. 4The Renal Kallikrein-Kinin System: Its Role as a Safety Valve for Excess Sodium Intake, and Its Attenuation as a Possible Etiologic Factor in Salt-Sensitive Hypertension29 September 2008 | Critical Reviews in Clinical Laboratory Sciences, Vol. 40, No. 1B 2 receptor activation reduces Erk1 and Erk2 phosphorylation induced by insulin-like growth factor-1, platelet-derived growth factor-BB, and high glucose in rat isolated glomeruliCanadian Journal of Physiology and Pharmacology, Vol. 80, No. 4Distinct Modulation of Superficial and Juxtamedullary Arterioles by Prostaglandin in Vivo.Hypertension Research, Vol. 25, No. 6Optimal strategies for preventing progression of renal disease: Should angiotensin converting enzyme inhibitors and angiotensin receptor blockers be used together?Current Hypertension Reports, Vol. 2, No. 5Regional Renal Haemodynamics of Angiotensin II Infusion under Prostaglandin, Kinin or Converting Enzyme Inhibition in the Wistar Rat8 July 2009 | Blood Pressure, Vol. 9, No. 2-3Differing effects of enalapril and losartan on renal medullary blood flow and renal interstitial hydrostatic pressure in spontaneously hypertensive rats.Journal of Hypertension, Vol. 17, No. 9Local Renal Medullary L-NAME Infusion Enhances the Effect of Long-Term Angiotensin II TreatmentHypertension, Vol. 33, No. 1ACE Inhibitors and Renal Vascular Responses in the Spontaneously Hypertensive Rat29 June 2016 | Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 3, No. 2Renal Medullary Blood Flow and Renal Medullary Antihypertensive Mechanisms3 July 2009 | Clinical and Experimental Hypertension, Vol. 20, No. 1Renal hemodynamic response to ureteral obstruction during converting enzyme inhibitionUrological Research, Vol. 24, No. 4Relative Contribution of Angiotensin II, Bradykinin, and Prostaglandins to the Renal Effects of Converting Enzyme Inhibition in Rats After Chronic Myocardial InfarctionJournal of Cardiovascular Pharmacology, Vol. 28, No. 1ACE Inhibition Prevents and Reverses L-NAMEExacerbated Nephrosclerosis in Spontaneously Hypertensive RatsHypertension, Vol. 27, No. 2Role of Kinins in the Renal Response to Enalaprilat in Normotensive and Hypertensive RatsHypertension, Vol. 27, No. 2DO KININS MEDIATE CARDIOPROTECTIVE AND RENOPROTECTIVE EFFECTS OF CILAZAPRIL IN SPONTANEOUSLY HYPERTENSIVE RATS WITH RENAL ABLATION?Clinical and Experimental Pharmacology and Physiology, Vol. 22, No. s1IMPACT OF CYCLO-OXYGENASE BLOCKADE ON JUXTAMEDULLARY MICROVASCULAR RESPONSES TO ANGIOTENSIN II IN RAT KIDNEYClinical and Experimental Pharmacology and Physiology, Vol. 22, No. 10Nitric Oxide and Prostaglandins in the Prolonged Effects of Losartan and Ramipril in HypertensionHypertension, Vol. 26, No. 2The Renal Medulla and HypertensionHypertension, Vol. 25, No. 4The effect of kinin and prostaglandin inhibitors on the renal response to angiotensin-converting enzyme inhibition: a micropuncture study in the dogPflügers Archiv European Journal of Physiology, Vol. 427, No. 3-4 More from this issue > Volume 260Issue 3March 1991Pages C670-C672 Copyright & PermissionsCopyright © 1991 the American Physiological Societyhttps://doi.org/10.1152/ajpcell.1991.260.3.C670History Published online 1 March 1991 Published in print 1 March 1991 Metrics