Catalytic thermochemical conversion offers a sustainable method to upgradeoil-based feedstocks into highly valuable biofuel, aligning with the modern biorefinery concept. Herein,aseries of IrRe/SAPO-11 catalysts with different Ir to Re molar ratios compared to reference Ir/SAPO-11 and Re/SAPO-11 catalysts was prepared using a wetness impregnation method. These catalysts were used for the direct production of sustainable aviation fuels (SAFs) via efficient hydrodeoxygenation and hydroisomerization of triglycerides.The catalyst screening confirmed that the optimum IrRe/SAPO-11 catalyst, with an equivalent Ir to Re molar ratio, exhibited the highesthydrodeoxygenation activity under milder operation conditions thanthe conditions used in previous studies. Increasing thereaction temperature up to 330 °C enhanced the formation of iso-alkanes in the liquid product, achieving a freezing point of -31.4 °C without additional cold flow improvers. Furthermore, a long-term stability experiment demonstrated that the developed Ir-Re system exhibited exceptional performance over 150 h. This excellent catalytic activity and stability of the bifunctional IrRe/SAPO-11 catalyst was owing to its suitable interface between metallic and oxide sites, mixed mesoporous structures, reduced catalyst size, and increased Lewis acid ratio, as confirmed by our comprehensive characterizations.