The Bissau HIV cohort was initiated in 2007 and a cohort profile was published in 2014.1 The aim was to gain insights into different HIV types, human immunodeficiency virus 1 (HIV-1), human immunodeficiency virus 2 (HIV-2) and HIV 1/2-dual infections and human t-lympotropic virus 1 (HTLV-1) and tuberculosis and other co-infections. It was established at Hospital Nacional Simão Mendes (HNSM), the main hospital in Bissau, as a collaboration between researchers from the Bandim Health Project [https://www.bandim.org/], Aarhus University Hospital and local nurses and doctors from HNSM. The original cohort was singl-centred at HNSM and, by the time of the original cohort article in 2014, included 3765 patients. The cohort was continuously updated when patients arrived at the clinic for antiretroviral treatment (ART) supplies and clinical evaluations. Besides ART and clinical outcomes, the cohort has also been used to study co-infections such as HTLV,2,3 Hepatitis B and C,4 tuberculosis,5,6 cryptococcus,7 cytomegalovirus (CMV),8 pneumocystic jiroveci9 and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)10 that are prevalent.