Cognitive Level Research Articles

Optimization of the cooperative electronic commerce model for sustainable development in the context of ecological environment conservation

AbstractThis study aims to explore how to optimize the cooperative electronic commerce model in a sustainable ecological environment to meet the needs of consumers while maximizing social and economic benefits. The empirical research method is adopted, which mainly includes a literature review, case analysis, and questionnaire. Firstly, through a literature review, this study introduces and analyses the concept of sustainable ecological environment and the development and optimization direction of cooperative electronic commerce model in detail, providing a theoretical basis and thought guidance for subsequent research. Secondly, this study selects several representative cooperative electronic commerce platforms for case analysis. It explores their operation mode, product characteristics, service quality, and social benefits to summarize the experience and lessons of optimizing cooperative electronic commerce model. Finally, a questionnaire is designed to sample the consumers of cooperative electronic commerce. By analysing the results of questionnaire, the following conclusions are drawn. (1) 54.3% of respondents said they had used the cooperative electronic commerce model, with agricultural products purchasing (23.5%) and community service (18.9%) using it more frequently. (2) The cognition level of sustainable development was high overall, with 62.6% believing that it was essential for the future. (3) A multiple linear regression model explored the relationship between using the cooperative electronic commerce model and sustainable development cognition. The results reveal that adopting cooperative electronic commerce model has a significant positive impact on the cognition of sustainable development, which indicates that the promotion and use of this model can promote cognition and practice of sustainable development.

Coparenting Representations and Interactions Among Parents of Preschoolers with an Autism Spectrum Disorder

SYNOPSIS Objective. Coparenting (CP) representations as assessed using self-report or interviews are associated with coparental behavior among families with typically developing (TD) children. The current study examined whether the same would apply among families with children with an Autism Spectrum Disorder (ASD), or that there would be no such association due to the communication and behavioral difficulties related to children’s diagnosis. Design. The CP representations of parents of 80 preschooler boys with ASD were assessed using self-report, and CP behaviors were assessed in the Lausanne Trilogue Play (LTP) procedure and in a novel Coparental conversation task. Results. More positive CP representations as reported by mothers, but not fathers, were associated with more positive Coparental behaviors during the LTP and during the parental conversation task, even after controlling for children’s cognitive level and severity of symptoms and for parents’ Broad Autism Phenotype and years of education. Conclusions. Coparenting as studied in families of TD children is applicable in families with children with ASD.

Peripheral CD4+ T cell phenotype and brain microglial activation associated with cognitive heterogeneity in aged rats.

Cognitive decline is a critical hallmark of brain aging. Although aging is a natural process, there is significant heterogeneity in cognition levels among individuals; however, the underlying mechanisms remain uncertain. In our study, we classified aged male Sprague‒Dawley rats into aged cognition-unimpaired (AU) group and aged cognition-impaired (AI) group by using an attentional set-shifting task. The transcriptome sequencing results of medial prefrontal cortex (mPFC) demonstrated significant differences in microglial activation and inflammatory response pathways between the two groups. Specifically, compared to AU rats, AI rats exhibited a greater presence of CD86-positive microglia and major histocompatibility complex class II (MHC-II)-positive microglia, along with elevated inflammatory molecules, in mPFC. Conversely, AI rats exhibited a reduction in the percentage of microglia expressing CD200R and the anti-inflammatory molecules Arg-1 and TGF-β. Additionally, peripheral blood analysis of AI rats demonstrated elevated levels of Th17 and Th1 cells, along with proinflammatory molecules; however, decreased levels of Treg cells, along with anti-inflammatory molecules, were observed in AI rats. Our research suggested that peripheral Th17/Treg cells and central microglial activation were associated with cognitive heterogeneity in aged rats. These findings may provide a new target for healthy aging.

Integration of Teaching Resources for English Majors under Local Autonomy: Collaboration and Development

In the process of local social governance, educational resources are the basic conditions for social governance, so the integration of English education resources has become the main research aspect of local governments and educational institutions. The integration of key educational resources needs to be supported by local education policies, education systems and education laws, and the corresponding regulations and laws should be improved, and the English cognitive level of the public and the environmental governance of education need to be intervened by local governments, as well as the extensive participation of the public. Laws and regulations should be improved under the guidance of the government to provide support for the integration of English education resources, and the public should widely participate in the integration of educational resources of English majors under the publicity of educational resources, so as to form a good interactive relationship to provide support for local education governance. Therefore, the necessary conditions for the integration of local governments, legal institutions, education departments and the general public, military and local English education resources play a role in promoting the development level of English and the creation of a social environment.

Human-computer interaction interface design of flight simulator based on situation awareness.

To meet the comprehensive requirements of drivers for Human-Computer Interaction (HCI) during operation and to enhance situation awareness (SA), this paper proposes a design and evaluation method for flight simulator HCI interfaces grounded in SA. Firstly, the widely adopted Endsley's SA model, which comprehensively covers processes relevant to individual drivers was selected as the foundational framework. The study concentrates on flight, cruise, and landing scenarios within the simulator, analyzing and restructuring the information architecture of the HCI interface. Secondly, a self-assessment scale was developed based on the three-level model of information processing for SA to measure drivers' SA cognitive levels. The core scenarios of the simulation training were analyzed to establish a design-making process. Thirdly, invite participants were invited to engage in simulated driving sessions on the flight simulator, where their SA cognitive levels were assessed. An analysis of detail features was performed on samples with high SA cognitive levels. Subsequently, drivers' requirements for the control layout features of the HCI interface design were gathered through surveys. The design detail features of the HCI interface associated with high SA cognitive levels were identified and synthesized into four distinct dimensions to guide the detailed design process. Finally, participants engaged in simulated driving using the finalized interface design, and their SA cognitive levels were reassessed. The results demonstrated that the HCI interface design derived from this method significantly improved SA cognitive levels compared to the original design.

Serum High Mobility Group Box 1 (HMGB1) Protein Levels and Cognitive Function in Epilepsy Patients: A Cross-Sectional Study

Background: Epilepsy is a neurological disease with a high incidence rate. Cognitive decline is one of the consequences of recurrent seizures. Neuroinflammation is closely related to the development of epilepsy and cognitive impairment. An increase in the expression and translocation of High Mobility Group Box 1 (HMGB1) from the nucleus to the extracellular space has been observed in epilepsy patients and experimental animal models. This study aimed to investigate the relationship between serum HMGB1 levels and cognitive function in epilepsy patients. Methods: This cross-sectional observational study involved 45 epilepsy patients. Cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina), and serum HMGB1 levels were measured using the ELISA technique. The relationship between cognitive function and HMGB1 levels was analyzed using the Kruskal-Wallis test, with a significance level set at p < 0.05. Results: The mean age of the participants was 28.5 years, with a higher proportion of females. The mean serum HMGB1 level was 22.6 ng/ml. No significant relationship was found between serum HMGB1 levels and cognitive function in epilepsy patients (p = 0.188). Conclusion: Serum HMGB1 protein levels were not associated with cognitive function in this sample of epilepsy patients.

Facilitating Students' Cognitive Engagement in Online Asynchronous Discussion Within a Remote English Foreign Language Learning Environment

This study examined the cognitive presence of students in an asynchronous online discussion in the Second Language Acquisition (SLA) course. The course combined synchronous meetings through Zoom sessions to support student participation in asynchronous discussions. The study involved a cohort of 36 participants from the two remote extended campuses of Pattimura University in Maluku. Through content analysis, two key aspects were examined: (1) student participation rates, and (2) the extent of students’ cognitive presence within the discussions. The content analysis findings revealed that although each student made a minimum of two contributions per topic during online asynchronous discussions, they exhibited a moderately high level of cognition, incorporating problem recognition, exploration, integration, and solution, not only in individual messages but also in the overall exchange of information within the discussion thread. These findings suggest that a combination of synchronous meetings through Zoom sessions, tailored prompts, feedback, and social interactions enhances students' active engagement and utilization of cognitive skills in online asynchronous discussions. Keywords: online asynchronous discussion, English foreign language learning, cognitive presence

Quantifying neurobehavioral profiles across neurodevelopmental genetic syndromes and idiopathic neurodevelopmental disorders.

To examine neurobehavioral findings in three genetic syndromes (PTEN hamartoma tumor syndrome, Malan syndrome [mutations in the NFIX gene], and SYNGAP1-related disorder), a mixed group of other neurodevelopmental genetic syndromes (NDGS), idiopathic neurodevelopmental disorder, and neurotypical control participants. Using a longitudinal case-control design, caregivers reported neurobehavioral information for 498 participants (PTEN hamartoma tumor syndrome n = 112, Malan syndrome n = 24, SYNGAP1-related disorder n = 47, other NDGS n = 72, idiopathic neurodevelopmental disorder n = 54, neurotypical siblings n = 74, and unrelated neurotypical control participants n = 115) at three timepoints (baseline, and 1-month and 4-month follow-ups) using the online-administered Neurobehavioral Evaluation Tool (NET). NET scales had good scale and test-retest reliability. Unique patterns of neurobehavioral findings emerged, with SYNGAP1-related disorder and Malan syndrome showing generally more severe symptom and skill patterns than for other groups of patients. Patterns could be partly accounted for by estimated cognitive level, speech level, and the presence of autism spectrum disorder. However, even when accounting for these factors, group differences remained. Reliable change indices are reported. Genetic syndromes associated with neurodevelopmental disorders present with unique neurobehavioral profiles that can inform selection of outcome measures in future clinical trials. The NET may be a useful screening and monitoring instrument in clinical practice, where frequent in-person clinic attendance is difficult for many patients.

Measurement Invariance for Multilingual Learners Using Item Response and Response Time in PISA 2018

AbstractThis study examines potential assessment bias based on students' primary language status in PISA 2018. Specifically, multilingual (MLs) and nonmultilingual (non‐MLs) students in the United States are compared with regard to their response time as well as scored responses across three cognitive domains (reading, mathematics, and science). Differential item functioning (DIF) analysis reveals that 7–14% of items exhibit DIF‐related problems in scored responses between the two groups, aligning with PISA technical report results. While MLs generally spend more time on the test than non‐MLs across cognitive levels, differential response time (DRT) functioning identifies significant time differences in 7–10% of items for students with similar cognitive levels. It was noticeable that items with DIF and DRT issues show limited overlap, suggesting diverse reasons for student struggles in the assessment. A deeper examination of item characteristics is recommended for test developers and teachers to gain a better understanding of these nuances.

Question Paper Generation using Bloom’s Taxonomy

The "Question Paper Generator using Bloom's Taxonomy" is a high-tech, AI-based tool designed to make the generation of varied and well-balanced assessments easier for instructors. A wide variety of input sources, including syllabus documents, banks of questions, and even historical exams, are analysed and classified by NLP and machine learning into Bloom's Taxonomy cognitive levels: Remember, Understand, Apply, Analyse, Evaluate, and Create. The AI model is actually placed in an intuitive web application with which application with which educators can readily update such parameters as total marks, question difficulty, and the distribution of cognitive levels. This tool provides a logical interface where users can create assessments centered on standards for education and elicit thinking at different cognitive dimensions. Additionally, the web application feeds back a graphic report that plots through Bloom's Taxonomy in such a way that cognitive distribution is just and transparent. With the infusion of AI in a web- based setting, the tool brings forth practical and accessible solutions for educators in automating question papers creation to enrich their assessments. This application, therefore, holds best practices in instructional design through efficiency and scalability in the approach towards educational evaluation.

Proposal of a catalogue of criteria for the identification and classification of metaphorical collocations

Abstract This article focuses on metaphorical collocations, a special subtype of lexical collocations in which the cohesion between the constituents is based on a lexicalised metaphor (see Reder 2006; Volungevičienė 2008; Konecny 2010a, 2010b, 2023). The word combinations in question can develop from originally free sequences into recurrent patterns appearing in several semantically related collocations if they occur repeatedly in similar contexts (see Stojić and Košuta 2020, 2021). A case in point is the German collocation die Zeit verfliegt and its equivalents in Croatian, English and Italian: vrijeme leti (‘time flies’), time flies (by), and il tempo vola (via) (‘time flies (away)’), which convey a rapid movement and the feeling of time rushing by. The various patterns often also reflect cultural concepts and experiences; for example, a pattern that conceptualises time as a resource could be anchored in a cultural idea that regards time as something valuable. Metaphorical collocations thus frequently reflect superordinate conceptual metaphors that are located at a cognitive level and common to more than one language community. Nevertheless, the concrete language-specific manifestations may vary, and in many cases show only partial equivalence. Unlike idioms, where metaphor has long been recognised as a fundamental semantic process (see, e.g., Casadei 1996: passim; Dobrovol’skij and Piirainen 2009: 19–29), collocations have not been thoroughly examined in this regard. It is therefore necessary to gain a more detailed insight into the semantic-cognitive processes underlying the creation of lexical combinations to draw conclusions regarding their relevance for the emergence of collocational sequences. This requires an analysis of extensive authentic language material, which will allow for the development of a catalogue of criteria that facilitates the identification and classification of these specific linguistic phenomena. This paper focuses on uncovering such processes based on a study carried out using SketchEngine in web corpora of German, Croatian, English, and Italian with the aim of creating a clear framework for the identification of metaphorical collocations by elaborating criteria that can serve as guidelines and by attempting a classification into subtypes. The proposed criteria and typology can contribute to the systematic investigation of metaphorical collocations and should also open up perspectives for future work in this field.

Survey of fear and compliance of Insulin Degludec and Insulin Aspart injection in type 2 diabetes mellitus patients and analysis of influencing factors.

This study aims to investigate the fear and compliance of Insulin Degludec and Insulin Aspart (IDegAsp) injection in type 2 diabetes mellitus (T2DM) patients and study the factors influencing patient compliance. A total of 120 patients with T2DM treated from February 2019 to March 2022 were investigated and analyzed for fear and compliance on the Diabetes Fear of Injecting and Self-testing Questionnaire of diabetic patients and were divided into compliance and noncompliance groups according to the results to analyze the factors affecting patient compliance. The study found a high level of fear of IDegAsp injection among the 120 T2DM patients, with an average Diabetes Fear of Injecting and Self-testing Questionnaire score of (39.19 ± 4.59) points. Scores for medication compliance, dietary compliance, blood sugar monitoring, and lifestyle changes were (10.48 ± 1.52) points, (12.18 ± 2.27) points, (0.84 ± 0.12) points, and (9.13 ± 2.21) points, respectively. There was no significant difference between the compliance and noncompliance groups in terms of gender, age, lifestyle, educational level, occupation, current treatment method, family monthly income per capita, and medical payment method (P > .05). However, there were significant differences influenced by disease duration, complications, cognitive level, self-efficacy level, comorbidity count, and living status (P < .05). Multifactorial analysis showed that educational level, disease duration, complications, cognitive level, self-efficacy level, comorbidity count, and living status all affected patient compliance (P < .05). Educational level, disease duration, complications, cognitive level, self-efficacy level, comorbidity count, and living status are important factors affecting the fear and treatment compliance of IDegAsp injection in T2DM patients. These findings have implications for improving patient compliance and alleviating treatment fear.

Task-based pronunciation teaching: Lack of auditory precision but not memory hinders learning

This study examined the impact of individual differences in perception and cognition on the effectiveness of task-based pronunciation teaching (TBPT). Seventy young adult Chinese speakers were randomly assigned to either an experimental or control group. The experimental group participated in a 30-min TBPT session, engaging in meaning-oriented tasks designed to help them notice and practice two English vocalic contrasts: [ɛ]-[æ] (e.g., “set” vs. “sat”) and [ɪ]-[i] (e.g., “sit” vs. “seat”). Participants’ learning patterns were then assessed based on their aptitude on perceptual (auditory processing) and cognitive (working memory) levels. Analysis of pre- and post-test results, conducted through forced-choice identification tasks, revealed significant improvements in vowel performance (approximately 10% gain), particularly among participants with normative auditory precision. However, the effectiveness of TBPT was limited among those with lower auditory precision. These findings highlight the negative impact of lower-order aptitude, specifically auditory processing, on the efficacy of TBPT.

Neural bases of social facilitation and inhibition: how peer presence affects elementary eye movements.

Social Facilitation/Inhibition (SFI) refers to how others' presence influences task performance positively or negatively. Our previous study revealed that peer presence modulated saccadic eye movements, a fundamental sensorimotor activity. Pro- and anti-saccades were either facilitated or inhibited depending on trial block complexity (Tricoche et al., 2020). In the present fMRI study, we adapted our paradigm to investigate the neural basis of SFI on saccades. Considering inter- and intra-individual variabilities, we evaluated the shared and distinct neural patterns between social facilitation and inhibition. We predicted an involvement of the saccade-related and attention networks, alongside the Theory-of-Mind (ToM) network, with opposite activity changes between facilitation and inhibition. Results confirmed peer presence modulation in fronto-parietal areas related to saccades and attention, in opposite directions for facilitation and inhibition. Additionally, the ventral attention network was modulated during inhibition. Default mode regions, including ToM areas, were also modulated. Finally, pupil size, often linked to arousal, increased with peers and correlated with dorsal attention regions and anterior insula activities. These results suggest that SFI engages task-specific and domain-general networks, modulated differently based on observed social effect. Attention network seemed to play a central role at both basic (linked to arousal or vigilance) and cognitive control levels.

The Effectiveness of Remote Exercise Rehabilitation Based on the "SCeiP" Model in Homebound Patients With Coronary Heart Disease: Randomized Controlled Trial.

While exercise rehabilitation is recognized as safe and effective, medium- to long-term compliance among patients with coronary heart disease (CHD) remains low. Therefore, promoting long-term adherence to exercise rehabilitation for these patients warrants significant attention. This study aims to investigate the impact of remote exercise rehabilitation on time investment and related cognitive levels in homebound patients with CHD. This study utilizes the SCeiP (Self-Evaluation/Condition of Exercise-Effect Perception-Internal Drive-Persistence Behavior) model, alongside WeChat and exercise bracelets. A total of 147 patients who underwent percutaneous coronary intervention in the cardiovascular department of a grade III hospital in Jiangsu Province from June 2022 to March 2023 were selected as study participants through convenience sampling. The patients were randomly divided into an experimental group and a control group. The experimental group received an exercise rehabilitation promotion strategy based on the "SCeiP" model through WeChat and exercise bracelets, while the control group followed rehabilitation training according to a standard exercise rehabilitation guide. The days and duration of exercise, levels of cardiac rehabilitation cognition, exercise planning, and exercise input were analyzed before the intervention and at 1 month and 3 months after the intervention. A total of 81 men (55.1%) and 66 women (44.9%) were recruited for the study. The completion rate of exercise days was significantly higher in the experimental group compared with the control group at both 1 month (t145=5.429, P<.001) and 3 months (t145=9.113, P<.001) after the intervention. Similarly, the completion rate of exercise duration was significantly greater in the experimental group (t145=3.471, P=.001) than in the control group (t145=5.574, P<.001). The levels of autonomy, exercise planning, and exercise input in the experimental group were significantly higher than those in the control group at both 1 month and 3 months after the intervention (P<.001). Additionally, the experimental group exhibited a significant reduction in both process anxiety and outcome anxiety scores (P<.001). Repeated measures ANOVA revealed significant differences in the trends of cognitive function related to cardiac rehabilitation between the 2 patient groups over time: autonomy, F1,145(time×group)=9.055 (P<.001); process anxiety, F1,145(time×group)=30.790 (P<.001); and outcome anxiety, F1,145(time×group)=28.186 (P<.001). As expected, the scores for exercise planning (t145=2.490, P=.01 and t145=3.379, P<.001, respectively) and exercise input (t145=2.255, P=.03 and t145=3.817, P<.001, respectively) consistently demonstrated superiority in the experimental group compared with the control group at both 1 and 3 months after the intervention. Interestingly, we observed that the levels of exercise planning and exercise input in both groups initially increased and then slightly decreased over time, although both remained higher than the preintervention levels (P<.001). The remote health intervention based on the "SCeiP" model effectively enhances exercise compliance, exercise planning, exercise input, and cognitive levels during cardiac rehabilitation in patients with CHD. Chinese Clinical Trial Registry ChiCTR2300069463; https://www.chictr.org.cn/showproj.html?proj=192461.

Addressing mental health challenges in college students: A biomechanical approach to mitigating stress and cognitive load through physical intervention strategies

The main objective of this investigation is to find out how biomechanical actions, such as physical activity programs, balanced adjustments, and mindfulness-based posture correction, are successful at reducing Cognitive Load (CL) and levels of stress among college students. Mechanical adjustments decreased stress, physical activity reduced CL, and mindfulness-based posture correction improved Mental Health (MH), according to a long-term experiment with 28 students from four distinct educational fields. Investigators examined students’ stress, CL, and BH levels monthly. The outcome results dealt with all three predictions. A student’s Perceived Stress Scale (PSS) score dropped from 24.66 to 18.10 (mean difference = 6.56, t = 4.82, p = 0.0001) after experiencing practical changes, demonstrating a significant decrease in stress levels. Following the exercise support, CL, as determined by the NASA Task Load Index (NASA-TLX), dropped from 65.38 to 54.23 (mean difference = 11.15, t = 5.29, p = 0.00005). Ratings for BH increased significantly after exercising mindfulness-based posture correction (from 78.63 to 85.13; mean difference = −6.50, t = −4.92, p = 0.00007). The median variation in PF (VO2 Max) went from 40.46 to 45.11 (t = −3.78, p = 0.0012), and the difference in value was −4.65.

The funnel effect of reserves prompted by leisure activities across the Alzheimer's disease continuum.

Reserves' mechanisms explain inconsistencies between accumulation of neuropathological damage and clinical manifestations. Leisure activities are believed to promote reserves. This study evaluates whether cognitive, social, and physical leisure activities performed over life-span predict current cognitive functioning in normal aging and Alzheimer's disease (AD) continuum. 35 AD, 24 amnestic-Mild Cognitive Impairment (a-MCI) patients, 21 individuals with subjective cognitive complaint (SCD), and 25 controls underwent a questionnaire developed to quantify leisure activities in different life periods, the Addenbrooke's Cognitive Examination-Revised (ACE-R), and T1-weighted 3T-MRI scans for brain volumetrics and cortical thickness quantification. Partial/total leisure activities' scores and demographic and brain variables were entered as predictors, while ACE-R scores as dependent variables in linear regression analyses. Current level of cognition was predicted by (i) social and physical activities performed in middle age and current cognitive activity in AD; (ii) cognitive and social activities performed in middle age, current age and cortical thickness in a-MCI; (iii) recreational activities the set of lifetime, current age, and brain features in SCD; (iv) education and the set of lifetime leisure activities over lifespan in controls. This study shows a funnel effect due to gradual reduction of stimulatory activities in the transition from healthy aging to AD. Reserve indices taking into account different types of stimulatory activities allow to capture even smallest residual effects of reserves accumulated over lifespan, until their complete depletion at advanced AD stages. These results may help target tailored interventions during normal and pathological aging.

Sleep Hygiene for the Prevention of Hospital Delirium in Neurocritical Care Patients

Background Delirium is a state of altered level of consciousness often leading to confusion, inattention, and changes to levels of cognition. Delirium increases average length of stay in the hospital and costs the US health care system approximately $148 billion each year in associated medical costs. Sleep hygiene is an important factor in delirium prevention for all hospitalized patients. Objectives This quality improvement project was designed to increase implementation of an evidence-based sleep hygiene bundle in the neurocritical care population in order to decrease rates of hospital-acquired delirium. Methods This project followed the Plan, Do, Study, Act (PDSA) framework to facilitate a continuous quality improvement intervention at a mid-Atlantic academic medical center in the neurocritical care population. The continuous quality improvement included the incorporation of “sleep” as a topic into the daily rounding checklist, thus optimizing the ability to improve adherence to a multicomponent sleep hygiene bundle. The intervention includes the preintervention-postintervention occurrences of delirium and use of the daily rounding checklist. Results Nursing adherence to documentation of delirium assessments was high at approximately 99%. Following the intervention, there was a 41% decrease in the number of patients who screened positive for hospital-acquired delirium. Discussion The improvement in cases of hospital-acquired delirium may be attributed to the project intervention. Recommendations for future interventions include analysis of training on sleep plans, focus on nursing education regarding delirium assessment tools, or a measure of staff and/or patient satisfaction related to the intervention.

Implementation of Integrated Discovery Learning Model of Generic Science Skills to Improve HOTS

The purpose of this study was to determine the increase in students' high-order thinking skills after the application of the discovery learning model integrated with generic science skills on chemical equilibrium material in class XI of SMA Negeri 5 Tanjung Balai. The sampling technique was carried out using the random sampling technique, namely taking one class randomly by drawing lots. The design of this study was a one group pretest-posttest design. In learning, the test instruments used were cognitive levels C1 to C6, namely multiple choice questions. Through hypothesis testing using one sample T-Test, data significance was obtained &lt; 0.05 so that it can be concluded that Ha is accepted, which means that the average value of students taught with the discovery learning model integrated with generic science skills on chemical equilibrium material reached a minimum of 75.

Hippocampal Synaptic Plasticity Reduction Leads to Decreased Resilience to Depression and Anxiety in the ASCL-Mouse Model

A substantial body of research has been conducted with the objective of elucidating the role of synaptic plasticity in the aetiology of depression and anxiety. Despite the fact that numerous existing tests have demonstrated a correlation between neuroplasticity and depression, the precise role of synaptic plasticity remains unclear. The objective of this experiment is to elucidate the impact of hippocampal synaptic plasticity on resilience to depression and anxiety. The experiment comprises a preliminary test and a series of main experiments. The preliminary tests are conducted to eliminate the potential effects of apoptosis caused by the BAX gene. The main experiments then assess anxiety and cognitive levels by dividing subjects into multiple groups and administering a battery of tests. In a 40-week period, the mice will be modified and will experience major depression as a result of an 8-week UCMS treatment.