Less than half of those who need mental health counseling receive it globally, underscoring the urgent need for psychology-focused intervention. According to data, 30.9% of Nigerians experience psychological anguish. This study investigated the efficacy and moderators of group cognitive behaviour therapy in psychologically distressed schoolchildren with adventitious blindness in Nigeria. A total of 98 students with adventitious blindness were recruited and participated in this study. The participants were assessed at three points using Perceived Emotional Distress Inventory. A mixed model ANCOVA with repeated measures shows that the CBT treatment had a dependable significant effect in decreasing psychological distress. The results showed that sociodemographic factors do not significantly moderate the efficacy of CBT treatment on the reduction of psychological distress in schoolchildren with adventitious blindness. In conclusion, the effect of a group cognitive behavioural therapy had a consistent significant reduction in psychological distress and none of their sociodemographic characteristics moderated the effects. Therefore, cognitive-behavioural practitioners should collaborate with special schools to diagnose and provide CBT treatment to schoolchildren living with adventitious blindness.