Cognitive Abilities In Men Research Articles

Translocation of bacterial LPS is associated with self-reported cognitive abilities in men living with HIV receiving antiretroviral therapy

BackgroundGut damage allows translocation of bacterial lipopolysaccharide (LPS) and fungal β-D-glucan (BDG) into the blood. This microbial translocation contributes to systemic inflammation and risk of non-AIDS comorbidities in people living with HIV, including those receiving antiretroviral therapy (ART). We assessed whether markers of gut damage and microbial translocation were associated with cognition in ART-treated PLWH.MethodsEighty ART-treated men living with HIV from the Positive Brain Health Now Canadian cohort were included. Brief cognitive ability measure (B-CAM) and 20-item patient deficit questionnaire (PDQ) were administered to all participants. Three groups were selected based on their B-CAM levels. We excluded participants who received proton pump inhibitors or antiacids in the past 3 months. Cannabis users were also excluded. Plasma levels of intestinal fatty acid binding protein (I-FABP), regenerating islet-derived protein 3 α (REG3α), and lipopolysaccharides (LPS = were quantified by ELISA, while 1–3-β-D-glucan BDG) levels were assessed using the Fungitell assay. Univariable, multivariable, and splines analyses were performed.ResultsPlasma levels of I-FABP, REG3α, LPS and BDG were not different between groups of low, intermediate and high B-CAM levels. However, LPS and REG3α levels were higher in participants with PDQ higher than the median.Multivariable analyses showed that LPS association with PDQ, but not B-CAM, was independent of age and level of education. I-FABP, REG3α, and BDG levels were not associated with B-CAM nor PDQ levels in multivariable analyses.ConclusionIn this well characterized cohort of ART-treated men living with HIV, bacterial but not fungal translocation was associated with presence of cognitive difficulties. These results need replication in larger samples.

Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner.

The enzyme aromatase catalyzes the final step in estrogen biosynthesis, converting testosterone to estradiol, and is expressed in the brain of all mammals. Estrogens are thought to be important for maintenance of cognitive function in women, whereas testosterone is thought to modulate cognitive abilities in men. Here, we compare differences in cognitive performance in relation to brain aromatase availability in healthy men and women. Twenty-seven healthy participants were administered tests of verbal learning and memory and perceptual/abstract reasoning. In vivo images of brain aromatase availability were acquired in this sample using positron emission tomography (PET) with the validated aromatase radiotracer [11C]vorozole. Regions of interest were placed bilaterally on the amygdala and thalamus where aromatase availability is highest in the human brain. Though cognitive performance and aromatase availability did not differ as a function of sex, higher availability of aromatase in the amygdala was associated with lower cognitive performance in men. No such relationship was found in women; and the corresponding regression slopes were significantly different between the sexes. Thalamic aromatase availability was not significantly correlated with cognitive performance in either sex. These findings suggest that the effects of brain aromatase on cognitive performance are both region- and sex-specific and may explain some of the normal variance seen in verbal and nonverbal cognitive abilities in men and women as well as sex differences in the trajectory of cognitive decline associated with Alzheimer’s disease.

No difference in cognitive performance or gender role behavior between men with and without hypospadias

BackgroundHypospadias is a common malformation of the male external genitalia that results in urethral displacement with different levels of severity. Male genital development during the fetal period is dependent on androgen function, while the etiology of hypospadias differs and can be multifactorial. The psychosocial outcome is sometimes affected, but according to several studies acceptable. The question of whether hypospadias is associated with differences in psychosexual development has been investigated previously, with mixed results. There are no previous investigations of cognitive abilities in men with hypospadias. ObjectiveThe aim of this study was to investigate whether hypospadias is associated with differences in performance on cognitive tests and/or gender role behavior. ParticipantsEighty-six men with hypospadias were compared to male and female controls from the general population. ProcedureCognitive tasks, previously shown to yield group level sex differences and questions regarding self-reported childhood gender role behavior, were administered either at an outpatient clinic visit or via online participation. ResultsThe cognitive performance of men and women in the control groups differed significantly in the expected directions. Men and women also differed on self-reported childhood gender role behavior questions. There were no significant differences between men with and without hypospadias on any of the measures. Men with proximal hypospadias performed slightly lower on many of the cognitive tasks in comparison to men with distal hypospadias and controls. ConclusionIn general, hypospadias is not associated with differences in performance on cognitive tests that typically yield sex differences or with altered gender role behavior in childhood. Further studies on cognitive abilities in boys and men with proximal hypospadias are warranted.

Формирование профессиональных компетенций студентов на занятиях по курсовому проектированию

The work of the student on the course work is the most eff ective form to enhance and optimize the teaching and learning process, a way of strengthening his professional and applied orientation, helps to strengthen the connection of educational process with teaching and research activities, is an eff ective means of intensifying the focus of professional training of the student. To modern specialist society has a long list of requirements, among which important value has the presence of graduates of certain abilities and skills independently to extract knowledge from diff erent sources, to systematize received information, analyze the problem. The formation of such skills occurs
 during the whole study period. The independent work of students plays a crucial role in the entire educational process. The implementation of the course work contributes to the formation of the subject of cognitive activity, requires the creation of a complex of pedagogical conditions for the development of sustainable, high-quality learning motivation; in it the big role self-mastery of general and professional competences. In “Lebedyansky Commerce and Economic College” is constantly working to improve the quality of education. In the long term, the criterion for assessing
 the quality of the coursework should be the assessment of the degree of creativity and independence of students when performing this type of research. As creativity is based on cognitive abilities of man and covers the areas of personality, process, result, it will contribute to the development of creative elements of scientifi c knowledge, formation of professional qualities of students. The role of training coursework is particularly relevant in the present time, when educational institutions set the task of formation at students of need to continuous self-education, which supposes the ability for own cognitive activity.

MP-22.07: Long-term androgen deprivation and cognitive function in men with prostate cancer

There is evidence that testosterone plays an important role in the modulation of cognitive function. The objective of this study was further examining cognitive abilities in men who underwent long-term treatment with GnRH-agonistic analogues for prostate cancer.

Variation of Sicilian pond turtles, Emys trinacris – What makes a species cryptic?

Abstract Variation of the Sicilian pond turtle, Emys trinacris, is described, based on morphological data of more than 200 adult and immature turtles and mtDNA sequences of 31 new known-locality specimens. Emys trinacris is morphologically more variable than thought before. There exist pronounced population-specific differences. Adults are barely distinguishable from Emys orbicularis galloitalica. Hatchlings of E. trinacris are, however, significantly different patterned, allowing immediate species determination. Moreover, hatchlings of E. trinacris seem to be on average smaller and lighter than in E. orbicularis. This could be related with different reproductive strategies. Coloration polymorphism of adult Sicilian pond turtles comprises fair part of variation known in E. orbicularis. Thus, adult E. trinacris might have preserved the whole array of variation of the last common ancestor with E. orbicularis. We hypothesize that similarity of certain southern E. orbicularis subspecies and E. trinacris on one hand and pronounced differences in size, coloration and pattern of northern E. orbicularis subspecies on the other result from stabilising selection in the north. While dark coloration and large body-size seem to be beneficial in the north, light coloration and small size could be simply not disadvantageous in the south, allowing coloration polymorphisms in E. trinacris and southern E. orbicularis subspecies. Further, the term 'cryptic species' and its meaning in regard to species concepts and bar-coding is discussed. It is concluded that species delineation based on mtDNA barcoding requires application of a Phylogenetic Species Concept. Under the Biological Species Concept, animal mtDNA is not always an ideal tool for delineating species boundaries because taxa with monophyletic mitochondrial gene trees are neither necessarily genetically isolated nor must represent the same Biological Species. Cryptic species are nothing special in nature because difficulties with their identification are due to deficits in cognitive abilities of man. This is illustrated by the fact that distinct live stages of 'cryptic species' may differ to various degrees from similar species, as is the case in hatchlings and adults of E. trinacris and E. o. galloitalica.

Sex Differences and Individual Differences in Cognitive Performance and Their Relationship to Endogenous Gonadal Hormones and Gonadotropins.

Sexually dimorphic cognitive performance in men (n=42) and women (n=42) was related to testosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and sex hormone binding globulin, measured in 10-ml blood samples collected between 0900 and 1030 and, among women, during the follicular phase of the menstrual cycle. Significant sex differences favored men on spatial tasks (Mental Rotation and Judgment of Line Orientation) and on an inhibition task and favored women on a verbal task (category fluency). However, there were no significant relationships between any of the hormones and cognitive performance, suggesting that there are few, if any, consistent, substantial relationships between endogenous, nonfluctuating levels of gonadal hormones or gonadotropins and these cognitive abilities in men or women.

Dermatoglyphic Asymmetry is Related to Perceptual Asymmetry and to Interhemispheric Transmission

The numbers of ridges on the fingertips is asymmetrical between hands and is also sexually dimorphic. Most people have more ridges on the right hand (rightward dermatoglyphic asymmetry; R >) and men typically have more ridges than women. The direction of dermatoglyphic asymmetry has been shown to be related to patterns of cognitive abilities in men and women and to perceptual asymmetry in homosexual men. W e assessed presumptively heterosexual, right-handed men and women who had either R > (n = 35) or L > (n = 30) ridge count, on: (1) dichotic listening to words; (2) two tachistoscopic tasks sampling visual field asymmetries (dot location and letter identification); and (3) a tachistoscopic task designed to examine interhemispheric transmission. L > subjects had a smaller right-ear advantage than R > subjects, but this was accounted for by an increased incidence of an atypical left-ear advantage in the L > group. Visual field asymmetries were also smaller in the L > group but the asymmetry measures did not reach significance, with the exception of an increased incidence of an atypical field advantage (left) for letter recognition only. On the interhemispheric transfer task, L > subjects performed relatively faster on tasks requiring interhemispheric comparisons than did R > subjects. These findings confirm an association between the direction of dermatoglyphic asymmetry and aspects of brain organisation.

Dermatoglyphic Asymmetry is Related to Perceptual Asymmetry and to Interhemispheric Transmission

The numbers of ridges on the fingertips is asymmetrical between hands and is also sexually dimorphic. Most people have more ridges on the right hand (rightward dermatoglyphic asymmetry; R >) and men typically have more ridges than women. The direction of dermatoglyphic asymmetry has been shown to be related to patterns of cognitive abilities in men and women and to perceptual asymmetry in homosexual men. W e assessed presumptively heterosexual, right-handed men and women who had either R > (n = 35) or L > (n = 30) ridge count, on: (1) dichotic listening to words; (2) two tachistoscopic tasks sampling visual field asymmetries (dot location and letter identification); and (3) a tachistoscopic task designed to examine interhemispheric transmission. L > subjects had a smaller right-ear advantage than R > subjects, but this was accounted for by an increased incidence of an atypical left-ear advantage in the L > group. Visual field asymmetries were also smaller in the L > group but the asymmetry measures did not reach significance, with the exception of an increased incidence of an atypical field advantage (left) for letter recognition only. On the interhemispheric transfer task, L > subjects performed relatively faster on tasks requiring interhemispheric comparisons than did R > subjects. These findings confirm an association between the direction of dermatoglyphic asymmetry and aspects of brain organisation.

Synchronization in neuronal transmission and its importance for information processing

The cognitive abilities of man and his extensive memorizing capabilities are assumed to rely on cortical processing. Yet very little is known about the detailed mechanisms of these processes. One of the common approaches for studying cortical activity is by recording the activity of a single unit by means of a microelectrode. Typically, the function of such a single unit is investigated by studying the modulations of its firing rate. In the present chapter we show that it is possible to obtain additional information by studying spatiotemporal firing patterns.