CO2 heat pump water heater has raised considerable attention as an environmentally efficient technology for hot water production. However, after long-term operation, the deterioration of component performance will not only directly cause system performance degradation, but also lead to a deviation of discharge pressure from the actual optimum under different discharge pressure control strategies, further resulting in additional performance loss. So far, the additional performance loss in the long run has not been in-depth investigated. In this study, based on a validated system model of CO2 heat pump water heater with component performance degradation factors, the long-term additional loss of system performance under eight different discharge pressure control strategies are compared. The results reveal that additional performance loss in the long-term operation can be significant under certain control strategy and working conditions. As for the investigated system, the control strategy with the parameter group of ambient and gas cooler outlet temperatures is favorable for application under the nominal operating condition with long-term degradation of heat exchangers, and the average additional loss of COP (coefficient of performance) can be decreased to 0.62%. As for the compressor degradation, the optimal refrigerant charge management strategy is preferred with an average COP loss as low as 0.05% under certain working conditions. In facing with year-round performance degradation, the control strategy with the parameter group of evaporating temperature and gas cooler outlet temperature shows better robustness, since the average additional annual performance loss can be reduced to only 2.52%.