As a kind of clean energy, the exploration and development of coalbed methane (CBM) are of great importance and significance. In this paper, the CBM reservoir parameters of a working area in Western Guizhou Province, China, were predicted by using 3D seismic exploration technology, and the sweet-spot area was evaluated based on the prediction results. In terms of data interpretation, while the traditional technology is extended to the study of CBM, new technologies and methods suitable for CBM were also actively explored, especially in the quantitative prediction methods of parameters such as coal seam thickness, CBM content, coal body structure, in situ stress, etc., and a three-highs quantitative prediction technology of CBM sweet spots characterized by high precision, high resolution, and high coincidence was explored, which is based on logging evaluation and petrophysics. In addition, in the comprehensive evaluation of multiparameter sweet spots, the multiparameter weighted step-by-step evaluation method based on inversion was innovatively proposed, which made the prediction of CBM sweet spots more focused, effective, and practical, and the distribution law of sweet spots was more consistent with the geological law, providing enough basis for subsequent well location deployment. Based on this method, the C409 coal seam was selected as the sweet spot.