Co-occurrence Cluster Research Articles

Spiritual Leadership Research: Past, Present and Future Using Bibliometric Analysis.

Given a dearth of comprehensive assessments, this study provided a quantitative and scientific analysis of 286 articles on spiritual leadership (SL) published in Scopus-indexed journals. Citation, cluster and co-citation analysis were employed to highlight the key works, sketch the intellectual framework and identify the research gaps. The most influential documents, journals, authors/researchers, countries and universities were also determined using citation analysis. Besides author co-citation and journal co-citation, analysis were alsoperformed to determine the intellectual structure of SL literature, followed by a thorough review of authors' keywords utilizing cluster analysis. Keyword co-occurrence cluster analysis led to the identification of five major clusters/streams: (a) spiritual leadership and well-being; (b) spiritual leadership and other types of leadership; (c) spiritual leadership and creativity; (d) spiritual leadership and employee-level outcomes; (e) spiritual leadership, sustainability and spirituality. Future research directions were suggested within each identified cluster. This study will assist regulators and academic scholars in understanding the nuts and bolts of spiritual leadership and identifying areas that require more research.

Research Dynamics and Frontiers of Environmental, Social, and Governance Disclosure: Bibliometric Visual Analysis Based on CiteSpace

Abstract: With the increasing global attention on sustainable development and corporate social responsibility, studying the dynamics and frontiers of Environmental, Social, and Governance (ESG) disclosure is of great significance to academia, corporate practice, and policy-making. This study employs CiteSpace for bibliometric visual analysis, utilizing methods such as keyword co-occurrence analysis, cluster analysis, and research theme evolution analysis to comparatively analyze the differences in ESG research between domestic and international contexts. The study reveals the hotspots, trends, and development directions of ESG disclosure research. The findings indicate a steady growth in the number of publications in the ESG disclosure research field, with research themes shifting from singular environmental information disclosure to a more comprehensive focus on social responsibility and governance structures. This study not only provides researchers with new perspectives, expanding and deepening the themes of ESG research, but also offers references for companies to enhance ESG disclosure and for policy-making, thus holding significant theoretical and practical implications.

Mental health issues of higher education students reflected in academic research: A text mining study

Objective: This study investigated mental health issues among higher education students to identify key concepts, topics, and trends over three periods of time: Period 1 (2000–2009), Period 2 (2010–2019), and Period 3 (2020–May 2024). Methods: The study collected 11,732 bibliographic records from Scopus and Web of Science, published between January 2000 and May 2024, and employed textual analysis methods, including keyword co-occurrence analysis, cluster analysis, and topic modeling. Results: In Period 1, general topics related to mental health disorders and treatments were identified. Period 2 showed prominence of well-being and help-seeking, as well as the emergence of digital mental health. Period 3 emphasized the impact of COVID-19 and increased technology usage. Conclusions: Based on the findings, we discussed the significance of the study and practical implications for clinicians and policymakers, as well as methodological implications for researchers. Additionally, the limitations of the study and future research were addressed.

Servitization and product service system: A literature review on value creation

In recent years, the concept of servitization has been widely applied in the management of enterprises. However, changing customer demands and competitive pressures of the market have compelled enterprises to seek innovation. Simultaneously, in the context of the Industry 4.0 trend, the rapid development of digital technologies has led to an increasing number of studies on the integration of servitization and digitization. Therefore, this study, based on VOSviewer, Gephi, Scimago Graphica, and Histcite, analyzes the current state and development trends of research on servitization and product service system innovation from the perspective of value creation. Initially, basic statistical characteristics such as the influential author, geographical cooperation, and highly cited papers are presented by collecting relevant data from the Web of Science core collection database. Subsequently, this study explores the research hotspots and evolutionary trends in servitization and product service system innovation through keyword co-occurrence analysis and cluster analysis. Lastly, from a literature analysis perspective, the application of advanced technologies in servitization, digital servitization from an ecosystem perspective, and the innovative use of microservices architecture in product service systems are summarized and forecasted as research directions, providing theoretical guidance for future research in servitization.

Current trends and hotspots of depressive disorders with colorectal cancer: A bibliometric and visual study

BACKGROUND Depression is strongly associated with colorectal cancer (CRC). Few bibliometric analyses have systematically summarized the research focus and recent progress in this field. AIM To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and depression. METHODS Articles on depression in CRC patients were collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to visualize bibliometric networks. RESULTS From 2001 to 2022, Supportive Care in Cancer , the United States, Tilburg University, and Mols were the most productive and influential journal, country, institution, and author name. Co-occurrence cluster analysis of keywords placed quality of life, anxiety, and psychological stress in the center of the visual network diagram. Further clustering was performed for the clusters with studies of the relevant mechanism of action, which showed that: (1) Cytokines have a role essential for the occurrence and development of depressive disorders in CRC; (2) MicroRNAs have a role essential for the development of depressive disorders in CRC; (3) Some anticancer drugs have pro-depressant activity; and (4) Selective serotonin reuptake inhibitors have both antitumor and antidepressant activity. CONCLUSION Life quality and psychological nursing of the cancer population were key topics. The roles of cytokines and microRNAs, the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.

The Role of Akkermansia muciniphila on Improving Gut and Metabolic Health Modulation: A Meta-Analysis of Preclinical Mouse Model Studies.

Akkermansia muciniphila (A. muciniphila) and its derivatives, including extracellular vesicles (EVs) and outer membrane proteins, are recognized for enhancing intestinal balance and metabolic health. However, the mechanisms of Akkermansia muciniphila's action and its effects on the microbiome are not well understood. In this study, we examined the influence of A. muciniphila and its derivatives on gastrointestinal (GI) and metabolic disorders through a meta-analysis of studies conducted on mouse models. A total of 39 eligible studies were identified through targeted searches on PubMed, Web of Science, Science Direct, and Embase until May 2024. A. muciniphila (alive or heat-killed) and its derivatives positively affected systemic and gut inflammation, liver enzyme level, glycemic response, and lipid profiles. The intervention increased the expression of tight-junction proteins in the gut, improving gut permeability in mouse models of GI and metabolic disorders. Regarding body weight, A. muciniphila and its derivatives prevented weight loss in animals with GI disorders while reducing body weight in mice with metabolic disorders. Sub-group analysis indicated that live bacteria had a more substantial effect on most analyzed biomarkers. Gut microbiome analysis using live A. muciniphila identified a co-occurrence cluster, including Desulfovibrio, Family XIII AD3011 group, and Candidatus Saccharimonas. Thus, enhancing the intestinal abundance of A. muciniphila and its gut microbial clusters may provide more robust health benefits for cardiometabolic, and age-related diseases compared with A. muciniphila alone. The mechanistic insight elucidated here will pave the way for further exploration and potential translational applications in human health.

Metabolic reprogramming in hepatocellular carcinoma: a bibliometric and visualized study from 2011 to 2023.

Metabolic reprogramming has been found to be a typical feature of tumors. Hepatocellular carcinoma (HCC), a cancer with high morbidity and mortality, has been extensively studied for its metabolic reprogramming-related mechanisms. Our study aims to identify the hotspots and frontiers of metabolic reprogramming research in HCC and to provide guidance for future scientific research and decision-making in HCC metabolism. Relevant studies on the metabolic reprogramming of HCC were derived from the Web of Science Core Collection (WoSCC) database up until November 2023. The bibliometrix tools in R were used for scientometric analysis and visualization. From 2011 to 2023, a total of 575 publications were obtained from WoSCC that met the established criteria. These publications involved 3,904 researchers and 948 organizations in 37 countries, with an average annual growth rate of 39.11% in research. These studies were published in 233 journals, with Cancers (n = 29) ranking first, followed by Frontiers in Oncology (n = 20) and International Journal of Molecular Sciences (n = 19). The top ten journals accounted for 26% of the 575 studies. The most prolific authors were Wang J (n = 14), Li Y (n = 12), and Liu J (n = 12). The country with the most publications is China, followed by the United States, Italy, and France. Fudan University had the largest percentage of research results with 15.48% (n = 89). Ally A's paper in Cell has the most citations. A total of 1,204 keywords were analyzed, with the trend themes such as "glycolysis," "tumor microenvironment," "Warburg effect," "mitochondria," "hypoxia ," etc. Co-occurrence network and cluster analysis revealed the relationships between keywords, authors, publications, and journals. Moreover, the close collaboration between countries in this field was elucidated. This bibliometric and visual analysis delves into studies related to metabolic reprogramming in HCC between 2012 and 2023, elucidating the characteristics of research in this field, which has gradually moved away from single glycolipid metabolism studies to the integration of overall metabolism in the body, pointing out the trend of research topics, and the dynamics of the interaction between the tumor microenvironment and metabolic reprogramming will be the future direction of research, which provides blueprints and inspirations for HCC prevention and treatment programs to the researchers in this field.

Recent Progress on Physiologically Based Pharmacokinetic (PBPK) Model: A Review Based on Bibliometrics.

Physiologically based pharmacokinetic/toxicokinetic (PBPK/PBTK) models are designed to elucidate the mechanism of chemical compound action in organisms based on the physiological, biochemical, anatomical, and thermodynamic properties of organisms. After nearly a century of research and practice, good results have been achieved in the fields of medicine, environmental science, and ecology. However, there is currently a lack of a more systematic review of progress in the main research directions of PBPK models, especially a more comprehensive understanding of the application in aquatic environmental research. In this review, a total of 3974 articles related to PBPK models from 1996 to 24 March 2024 were collected. Then, the main research areas of the PBPK model were categorized based on the keyword co-occurrence maps and cluster maps obtained by CiteSpace. The results showed that research related to medicine is the main application area of PBPK. Four major research directions included in the medical field were "drug assessment", "cross-species prediction", "drug-drug interactions", and "pediatrics and pregnancy drug development", in which "drug assessment" accounted for 55% of the total publication volume. In addition, bibliometric analyses indicated a rapid growth trend in the application in the field of environmental research, especially in predicting the residual levels in organisms and revealing the relationship between internal and external exposure. Despite facing the limitation of insufficient species-specific parameters, the PBPK model is still an effective tool for improving the understanding of chemical-biological effectiveness and will provide a theoretical basis for accurately assessing potential risks to ecosystems and human health. The combination with the quantitative structure-activity relationship model, Bayesian method, and machine learning technology are potential solutions to the previous research gaps.

A mapping-knowledge-domain analysis of ERP research on language processing.

The event-related potentials (ERPs) technique represents a newly developed methodology in cognitive neuroscience and has significantly extended the scope of linguistic studies, offering valuable insights into cognitive processes related to language. While extant literature reviews have addressed specific facets of ERP research on language processing, a comprehensive overview of this domain remains notably absent. This study aims to fill this gap by pioneering a mapping-knowledge-domain analysis of ERP research on language processing using Citespace, a visualized bibliometric software. The current study conducted a meticulous survey and evaluation of relevant literature extracted from the Web of Science core collection. Initially, this study outlines the spatial-temporal distribution within this domain. Subsequently, employing document co-citation analysis, keyword co-occurrence analysis, cluster analysis, and burst detection analysis, this study delved deeper into the research landscape. Findings reveal that key areas in ERP research on language processing predominantly focus on sentence comprehension, reading comprehension, and mismatch negativity, with notable emphasis on topics such as speech perception, temporal dynamics, and working memory. The current study advocates for future investigations to concentrate on larger linguistic units, explore the integration of ERP components and their functional significance, and scrutinize individual differences among participants. These directions are imperative for advancing the understanding of language processing mechanisms.

Emotional labour in nursing research: A bibliometric analysis.

This study aims to conduct a comprehensive bibliometric analysis to explore the trajectory and thematic developments of emotional labour research in nursing. Utilizing descriptive and bibliometric analysis techniques. The data analysis and graphical presentation were conducted using the Bibliometrix Package in R software. The Web of Science Core Collection (WoSCC) database was searched on October 20, 2023. From 1992 to 2023, 842 authors published relevant articles, yielding 779 author keywords. There has been a general upward trend in the number of articles published over the past 30 years, with an annual growth rate of 11.71%. Keyword co-occurrence cluster analysis revealed the main focus areas of research on emotional labour antecedents and consequences, regulatory modalities, training and education, as well as research methods and application scenarios. Emotional labour significantly influences nursing staff's well-being and patient care outcomes. Effective management and education regarding emotional labour are crucial for enhancing nursing staff performance and patient care quality. Future research should focus on long-term effects, training efficacy, regulatory strategies across clinical settings, and innovative approaches to address current challenges. This study provides valuable insights into the unique trajectory and thematic developments of emotional labour research in nursing. The findings underscore the importance of addressing emotional labour in nursing practice and education to improve patient care outcomes and nursing staff well-being. Adherence to recognized bibliometric reporting methods, following relevant EQUATOR guidelines. This study is based solely on existing literature and did not involve patients or the public in its design, conduct, analysis, interpretation, or preparation.

A bibliometric analysis of non-coding RNA studies in acute pancreatitis.

Non-coding RNA (ncRNA) is a type of RNA that does not code for proteins and plays a crucial role in the onset, progression, diagnosis, and therapy of acute pancreatitis. However, bibliometric, and visual analyses of studies on acute pancreatitis and ncRNA are lacking. This study seeks to provide a bibliometric overview of the knowledge structure and research hotspots of ncRNA in the field of acute pancreatitis research. Literature search and collection of information in the field of ncRNA-related research in acute pancreatitis from 2000-2023 through the Web of Science Core Collection. Use CiteSpace and VOSviewer to visually analyze countries, institutions, authors, and keywords. A total of 563 articles have been published in the field of ncRNA-related research in acute pancreatitis, and the number of publications in this field is gradually increasing. The largest number of publications was from China. Four clusters were produced by the co-occurrence cluster analysis of the top 89 keywords: studies of ncRNA in inflammation, autophagy, and apoptosis in acute pancreatitis; studies related to microRNA expression in pancreatic cancer among ncRNA; studies related to microRNAs as diagnostic and therapeutic markers in acute pancreatitis; and studies related to ncRNA in acute pancreatitis; The key words "injury," "pathway" and "extracellular vesicles" are the key words of emerging research hotspots. In conclusion, ncRNA research in acute pancreatitis is an established discipline. Researchers can use the research hotspots and frontiers in this field as a guide for choosing their research direction.

Global trends in tumor microenvironment-related research on tumor vaccine: a review and bibliometric analysis.

Tumor vaccines have become crucial in cancer immunotherapy, but, only a limited number of phase III clinical trials have demonstrated clinical efficacy. The crux of this issue is the inability of tumor vaccines to effectively harmonize the tumor microenvironment with its intricate interplay. One factor that can hinder the effectiveness of vaccines is the natural immunosuppressive element present in the tumor microenvironment. This element can lead to low rates of T-cell response specific to antigens and the development of acquired resistance. Conversely, anticancer vaccines alter the tumor microenvironment in conflicting manners, inducing both immune activation and immunological evasion. Hence, comprehending the correlation between tumor vaccines and the tumor microenvironment would establish a foundation for forthcoming tumor treatment. Our review explores the realm of research pertaining to tumor vaccinations and the tumor microenvironment. Our objective is to investigate the correlation between tumor vaccines and the tumor microenvironment within this domain. We then focus our review on the dominant international paradigms in this research field and visually illustrates the historical progression and emergent patterns observed in the past. From January 1, 1999 to February 7, 2023, 1420 articles on the interplay between tumor vaccines and the tumor microenvironment were published, according to The Clarivate Web of Science (WOS) database used in our review. A bibliometric review was designed for this collection and consisted of an evaluation. The evaluation encompassed various discernible attributes, including the year of publication, the journals in which the articles were published, the authors involved, the affiliated institutions, the geographical locations of the institutions, the references cited, and the keywords employed. Between the years 1999 and 2022, publications saw a significant increase, from 3 to 265 annually. With 72 papers published, Frontiers in Immunology had the most manuscripts published. The Cancer Research publication garnered the highest number of citations, amounting to 2874 citations. The United States exerts significant dominance in the subject, with the National Cancer Institute being recognized as a prominent institution in terms of both productivity and influence. Furthermore, Elizabeth M. Jaffee was recognized as the field's most prolific and influential author with 24 publications and 1,756 citations. The co-occurrence cluster analysis was conducted on the top 197 keywords, resulting in the identification of five distinct clusters. The most recent high-frequency keywords, namely immune therapy, dendritic cell, tumor microenvironment, cancer, and vaccine, signify the emerging frontiers in the interaction between tumor vaccines and the tumor microenvironment. Our review uncovers insights into contemporary trends, global patterns of collaboration, fundamental knowledge, research areas of high interest, and emerging frontiers in the field of TME-targeted vaccines.

Global Scientific Trends in Continuous Renal Replacement Therapy from 2000 to 2023: A Bibliometric and Visual Analysis

Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear. Method: The WoSCC database was used to analyze CRRT research evolution and theme trends. VOSviewer was used to construct coauthorship, co-occurrence, co-citation, and network visualizations. CiteSpace is used to detect bursts for co-occurrence items. Several important subtopics were reviewed and discussed in more detail. Results: Global publications increased from 56 in 2000 to 398 in 2023, a 710.71% increase. Blood Purification published the most manuscripts, followed by the International Journal of Artificial Organs. The USA, the San Bortolo Hospital, and Bellomo were the most productive and impactful institution, country, and author, respectively. Based on co-occurrence cluster analysis, five clusters emerged: (1) clinical applications and management of CRRT; (2) sepsis and CRRT; (3) CRRT anticoagulant management; (4) CRRT and antibiotic pharmacokinetics and pharmacodynamics; and (5) comparison of CRRT and intermittent hemodialysis. COVID-19, initiation, ECOMO, cefepime, guidelines, cardiogenic shock, biomarker, and outcome were the latest high-frequency keywords or strongest bursts, indicating the emerging frontiers of CRRT. Conclusions: There has been widespread publication and citation of CRRT research in the past 2 decades. We provide an overview of current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers.

Research Hotspots on Fresh Cold Chain Logistics Based on CiteSpace

With the rapid development of today's logistics industry, fresh cold chain logistics, as one of the important branches of the logistics industry, is an important means to ensure the quality and safety of fresh products, and its development has attracted more and more attention. In this paper, 181 papers related to fresh cold chain in Chinese core journals and CSSCI journals from 1998 to 2023 in CNKI database were taken as research objects, and the methods of keyword co-occurrence map, cluster map, and emergent word detection provided by visualization software CiteSpace were used to sort out and summarize the collected data, and explore the research hotspots and frontiers in the field of logistics process of fresh cold chain products. At the same time, China's agricultural product cold chain logistics research groups are in a fragmented state, and distribution mode and fresh e-commerce are the current hot spots of agricultural product cold chain logistics research; At present, there are still problems such as long supply chain, many circulation links, high cost and loss in the cold chain logistics of agricultural products, and in-depth discussions should be carried out from the aspects of intelligent logistics and cold chain logistics in the future.

Bibliometric analysis of the current situation of research on the integration of Jiangxi’s red cultural resources into college students’ ideological and political education

Abstract Jiangxi is rich in red cultural resources, and the integration of red stories into the ideological and political education of university courses is an important topic worth exploring in the curriculum design of all university teachers. In this paper, we selected 1596 pieces of literature on the research of integrating red culture into college students’ civic education, included in Chinese and foreign language databases between 2004 and 2023, and used CiteSpace software to visualize and analyze the annual number of publications, authors, keywords and other aspects of the literature. Co-occurrence relationship analysis, cluster analysis, and emergence analysis of high-frequency keywords were conducted through bibliometrics to study the cutting-edge trends and hotspots of research in this field. The study shows that the current research on the integration of red culture into the current situation of college students’ ideological education is in a period of rapid development, and the research trends and hotspots in this field mainly focus on “red resources” and “curriculum ideology”, with the emergence intensities of 8.925 and 5.934 respectively. This study comprehensively grasps the research hotspots and development frontier trends in this field, provides a reference basis for the choice of research direction in this field, and provides ideas for promoting in-depth ideological and political education in Jiangxi universities.

Bibliometric and visualized analysis of cancer nanomedicine from 2013 to 2023.

Cancer nanomedicine has been an emerging field for drug development against malignant tumors during the past three decades. A bibliometric analysis was performed to characterize the current international trends and present visual representations of the evolution and emerging trends in the research and development of nanocarriers for cancer treatment. This study employed bibliometric analysis and visualization techniques to analyze the literature on antitumor nanocarriers published between 2013 and 2023. A total of 98,980 articles on antitumor nanocarriers were retrieved from the Web of Science Core Collection (WoSCC) database and analyzed using the Citespace software for specific characteristics such as publication year, countries/regions, organizations, keywords, and references. Network visualization was constructed by VOSviewer and Citespace. From 2013 to 2023, the annual global publications increased 7.39 times, from 1851 to 13,683. People's Republic of China (2588 publications) was the most productive country. Chinese Academy of Sciences (298 publications) was the most productive organization. The top 5 high-frequency keywords were "nanoparticles," "drug delivery," "nanomedicine," "cancer," and "nanocarriers." The keywords with the strongest citation bursts recently were "cancer immunotherapy," "microenvironment," "antitumor immunity," etc., which indicated the emerging frontiers of antitumor nanomedicine. The co-occurrence cluster analysis of the keywords formed 6 clusters, and most of the top 10 publications by citation counts focused on cluster #1 (nanocarriers) and cluster #2 (cancer immunotherapy). We further provided insightful discussions into the identified subtopics to help researchers gain more details of current trends and hotspots in this field. The present study processes a macro-level literature analysis of antitumor nanocarriers and provides new perspectives and research directions for future development in cancer nanomedicine.

Analysis of Viral Advertising Research Hotspots and Trends Based on Bibliometric Methods

With the popularity and development of social media, viral advertising has also gained tremendous development. Viral advertising as a useful promotional strategy can increase the publicity effectiveness of a brand or product. The purpose of this study is to better understand the research and progress of viral advertising and to explore future research directions. This study examined the viral advertising literature on the Web of Science database from 2004-2022, using bibliometric methods to analyze the data in terms of the annual number of publications, source journals, citations, authors, countries and institutions, and keywords. The results reveal the publishing trend of viral advertising research, the most influential literature and journals, as well as the most productive countries, institutions, and authors, including collaborative partnerships among them. The keyword co-occurrence analysis, cluster analysis, and time evolution analysis identified the research hotspots, themes, and evolution trends of viral advertising. This bibliometric study presents an overall profile of research in the field and proposes a research framework for the study of viral advertising that can serve as a reference, providing valuable guidance for advancing research in this area.

A bibliometric and visualized analysis of hepatic ischemia-reperfusion injury (HIRI) from 2002 to 2021

Hepatic ischemia-reperfusion injury (HIRI) is a complex pathological phenomenon dominated by the innate immune system and involves a variety of immune cells. This condition frequently occurs during hepatectomy, liver transplantation or hemorrhagic shock. HIRI represents an important factor in the poor prognosis of patients after liver surgery. However, there is still a lack of effective intervention to reduce the incidence of HIRI. In this study, we aimed to describe the overall structure of scientific research on HIRI over the past 20 years and provide valuable information and guidelines for future researchers. Bibliometric analysis was used to comprehensively review developments in HIRI and changes in our understanding of HIRI over the past two decades. We identified a total of 4267 articles on HIRI that were published over the past 20 years of which basic research was predominant. Collaboration network analysis revealed that China, the University of California Los Angeles, and Ronald W Busuttil were the most influential country, institute, and scholar, respectively. Co-occurrence cluster analysis revealed that ischemic preconditioning, liver cirrhosis, hepatic I/R injury, autophagy, acute liver failure, oxygen, donation after circulatory death, Nlrp3, remote organ, and microdialysis were the top 10 clusters. Keyword burst detection indicated that autophagy, inflammation, and early allograft dysfunction represent the current research hotspots. In summary, this is the first bibliometric analysis of HIRI research. Our timely analysis of these hotpots and research trends may provide a framework for future researchers and further promote research on the key mechanisms and therapeutic measures in this field.

Emerging trends and research foci in autophagy of pancreatic cancer: a bibliometric and visualized study.

The purpose of this study was to analyze the trends by year, country, institution, journal, reference and keyword in publications on the autophagy of pancreatic cancer (PC) and to predict future research hotspots. The Web of Science Core Collection was used to search for publications. The contributions of various countries/regions, institutes, authors, identified research hotspots, and promising future trends were analyzed using the VOSviewer1.6.16 and CiteSpace6.6.R2 programs. We also summarized autophagy relevant clinical trials of PC. A total of 1293 papers on the autophagy of PC published between 2013 and 2023 were included in the study. The average number of citations per article was 33.76. The China had the most publications, followed by USA, and a total of 50 influential articles were identified through co-citation analysis. Clustering analysis revealed clusters of keywords: metabolic reprogramming and ER stress, mTOR-mediated apoptosis, extracellular trap as the most concerned clusters. The co-occurrence cluster analysis showed pancreatic stellate cell, autophagy-dependent ferroptosis, autophagy-related pathway, metabolic rewiring, on-coding RNA as the highly concerned research topics in recently. The number of publications and research interest have generally increased over the past few years. The China and USA have made prominent contributions to the study of the autophagy of PC. The current research hotspots mainly focus not only on the related modulation, metabolic reprogramming, ferroptosis of tumor cells themselves, but also on tumor microenvironments such as autophagy associated pancreatic stellate cells and new treatments targeting autophagy.

Research status and trend of PPP in the US and China: visual knowledge mapping analysis

ABSTRACT Public-private-partnership (PPP) model has been widely used in public services and infrastructure projects, and many relevant studies on PPP have emerged. Based on CiteSpace and VOS viewer, this study aims to comprehensively analyze the research status and development trend of the PPP model in China and US. Firstly, the essential statistical characteristics of authors, institutions, and publications are given based on the relevant data collection in Web of Science core collection database. Secondly, the research hotspots and evolution trends of PPP by scholars in China and US are discussed by carrying out keywords co-occurrence analysis and cluster analysis. Finally, from the literature analysis and keyword co-occurrence network over time, the research directions, such as payment risks for the government during the operation period, early termination mechanism and system compensation mechanism, government supervision, and related information, are summarized and forecast, to provide theoretical guidance for the future research on PPP.