In this work, a series of Co–Cu–ZrO2 nanomaterials with different metal compositions were prepared by a reverse co-precipitation method, and used as catalyst for the production of methane from CO2 methanation reaction. The physicochemical properties of the catalysts were characterized by means of X-ray fluorescence (XRF), X-ray diffraction (XRD), N2-physisorption and hydrogen temperature-programmed reduction (H2-TPR). The binary Co–ZrO2 catalyst appeared to be predominant in the methanation process. The addition of Cu to the binary Co–ZrO2 catalyst decreased the reduction temperature of the catalysts and improved the inter-dispersion of mixed metal oxides. The Co–Cu–ZrO2 catalyst with the ratio of 20:40:40 achieved a superior CH4 yield of 58% at a reaction temperature and pressure of 300°C and 3MPa. Moreover, this catalyst exhibited a great stability as only a 0.6% reduction of initial CH4 yield was observed after 48h of a time-on-stream experiment.