This paper reports cluster-based cooperative spectrum sensing (CB-CSS) over Weibull, Nakagami, Rician, and Rayleigh fading channels in cognitive radio networks (CRNs). The performance assessment of centralized cooperative spectrum sensing (CCSS) and CB-CSS with different fusion rules over the Weibull fading channel is presented. The goal is to improve detection performance in a practical and efficient manner for CB-CSS. For this purpose, an expression for the optimal inter-fusion rule threshold (fusion rule between cluster head (CH) and fusion center (FC)) is proposed to minimize total error probability (TEP) over Weibull for CB-CSS. Simulations are conducted using analytical equations for missed detection and false alarm probability. The obtained expression for optimal inter-fusion rule threshold which minimizes TEP is verified by the results. The proposed model is validated with other fading channels such as Nakagami, Rician, and Rayleigh to show the superiority of the approach. It is observed that for a given range of detection threshold and for 4 × 6 cluster size (4 clusters and 6 CR users inside each cluster), the lowest total error probability is achieved over the Weibull fading channel. Minimum TEP over the Weibull fading channel for given network parameters is TEP = 1.656 × 10 − 6 when intra- and inter-fusion rules are l = 1 (OR fusion) and c = 3 . The least number of clusters and users essential to achieving target error bound over different fading channels are also determined.