Addendum8 December 2004free access A novel eukaryotic factor for cytosolic Fe–S cluster assembly Amit Roy Amit Roy Search for more papers by this author Natalia Solodovnikova Natalia Solodovnikova Search for more papers by this author Tracy Nicholson Tracy Nicholson Search for more papers by this author William Antholine William Antholine Search for more papers by this author William E Walden William E Walden Search for more papers by this author Amit Roy Amit Roy Search for more papers by this author Natalia Solodovnikova Natalia Solodovnikova Search for more papers by this author Tracy Nicholson Tracy Nicholson Search for more papers by this author William Antholine William Antholine Search for more papers by this author William E Walden William E Walden Search for more papers by this author Author Information Amit Roy, Natalia Solodovnikova, Tracy Nicholson, William Antholine and William E Walden The EMBO Journal (2004)23:4878-4878https://doi.org/10.1038/sj.emboj.7600518 This article corrects the following: A novel eukaryotic factor for cytosolic Fe–S cluster assembly15 September 2003 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info In the above article, the authors twice made the statement that Cfd1p was the first iron–sulfur cluster assembly factor to be found in the cytoplasm. Other recent publications have suggested that proteins that have been shown to function in Fe–S cluster assembly in mitochondria may exist at low levels in the cytoplasm (Land and Rouault, 1998; Tong and Rouault, 2000; Nakai et al, 2001). Since this article went to press, two additional papers have added to these findings (Tong et al, 2003; Nakai et al, 2004). While some investigators have questioned whether Cfd1p is indeed the first reported cytosolic Fe–S cluster assembly factor, we emphasize that the significance of our finding is in identifying a new class of cluster assembly factor whose localization is exclusively cytoplasmic and whose function is demonstrably cytoplasmic as well. References Land T, Rouault TA (1998) Targeting of a human iron–sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization. Mol Cell 2: 807–815CrossrefCASPubMedWeb of Science®Google Scholar Nakai Y et al (2001) Nuclear localization of yeast Nfslp is required for cell survival. J Biol Chem 276: 8314–8320CrossrefCASPubMedWeb of Science®Google Scholar Nakai Y et al (2004) Yeast Nfslp is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. J Biol Chem 279: 12363–12368CrossrefCASPubMedWeb of Science®Google Scholar Tong WH, Rouault T (2000) Distinct iron–sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. EMBO J 19: 5692–5700Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Tong WH et al (2003) Subcellular compartmentalization of human Nfu, an iron–sulfur cluster scaffold protein, and its ability to assemble a [4Fe–4S] cluster. Proc Natl Acad Sci USA 100: 9762–9767CrossrefCASPubMedWeb of Science®Google Scholar Next ArticlePrevious Article Read MoreAbout the coverClose modalView large imageVolume 23,Issue 24,December 8, 2004Calendar of Science - Inspired by Mayan calendars, this design contains representations of model organisms at different developmental stages, RNA, DNA, protein motifs, all centered around a symbol of biological science, the microscope. Holly A Field currently works on organogenesis of the liver and pancreas in Didier YR Stainier's lab at the University of California, San Francisco, USA. Volume 23Issue 248 December 2004In this issue ReferencesRelatedDetailsLoading ...