Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a significant precursor to hematological malignancies and is associated with several age-related diseases. We leveraged public data to explore differences in the mutational landscape of CHIP between males and females and across diverse racial populations.DNMT3A mutations were substantially more prevalent in females than in males (38.94% vs. 31.37%, p-value: <0.001, q-value: <0.001). While ASXL1 mutations were more frequent in males than females (5.82% vs 2.69%, p-value: <0.001, q-value: <0.001). In the racial cohorts with sufficient sample sizes, STAT5B and CSF1R mutations were most frequent in Asian (1.40% and 0.84%), followed by Black (0.98% and 0.24%) and White populations (0.29% and 0.09%), (p-value: 0.001 and 0.001, q-value: 0.023 and 0.023). Several other CHIP mutations were enriched in Black: RARA, SMAD2, CDKN1B, CENPA, CTLA4, EIF1AX, ELF3, MSI1, MYC, SOX17, AURKA. On the other hand, H3C1, H3C4, MYCL were enriched in the Asian cohort.Our analysis highlights sex and racial differences in the CHIP mutations among patients with cancer. As CHIP continues to gain recognition as a critical precursor to malignancies and other diseases, understanding how these differences contribute to CHIP underlying mechanisms and clinical implications is critical.