Clinical Features Of Melanoma Research Articles

Asymmetry analysis of melanoma based on ABCD rule

Malignant melanoma is a malignant tumor that is extremely harmful and prone to lymphatic metastasis. If it cannot be diagnosed and effectively treated at an early stage, it will cause irreversible consequences. There is a lot of evidence that if you can get the exact treatment in the early stage, it can effectively improve the recovery rate. At this stage, clinical diagnosis of melanoma is mainly performed manually, which has defects such as low overall efficiency. This article is based on ABCD rule, combined with the clinical features of melanoma in dermoscopic images, to determine the benign and malignant melanocytes. Firstly, the image processing technology and pattern recognition technology are used to acquire and preprocess the dermoscopic image, and the image feature points are extracted. Then, the microscopic asymmetry and macroscopic asymmetry of the image were analyzed. Finally, the symmetry score was calculated by TDS to judge the benign and malignant of melanocytes. It is expected to assist dermatologists in diagnosing melanoma, provide timely feedback information to patients and provide targeted treatment for patients, improve the efficiency and accuracy of medical clinical diagnosis, achieve the purpose of curing, and reduce the harm of melanoma to human health.

JAAD Game Changers: Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

JAAD Game Changers: Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

Incidence of melanoma in organ transplant recipients in Alberta, Canada.

Many studies have documented the increased risk of non-melanoma skin cancers in organ transplant recipients (OTRs). However, the incidence of melanoma is less well defined. To date, there have been no studies on the incidence of melanoma in Canadian OTRs. Herein, we determine the incidence and clinical features of melanoma in a cohort of OTRs in Southern Alberta, Canada. We used the Southern Alberta Transplant database to identify kidney and liver transplant recipients between the years 2000 and 2012. This population was cross-referenced with the Alberta Cancer Registry for a diagnosis of melanoma. The clinical features of all cases were obtained, and the standardized incidence rate was calculated. We identified 993 OTR patients, representing 5955 person-years. Only one patient developed a melanoma post-transplant, and this was a nodular melanoma. The age-standardized incidence rate was 11 per 100000 (0.6 per 5955), compared to 13.4 per 100000 in the general Alberta population (incidence rate ratio of 1.29, with 95% confidence interval of 0.17 to 9.82). This is the first Canadian study to investigate the association between organ transplantation and melanoma. Our study did not identify an increased risk of developing a de novo melanoma post-transplant.

Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

The incidence of melanoma in situ (MIS) is increasing, but little is known about its clinical and epidemiologic features. We sought to determine trends in diagnosis and clinical features of MIS. Incident cases of melanoma were collected prospectively from the Nurses' Health Study (1976-2010) and Health Professionals Follow-up Study (1986-2010). MIS incidence increased from 2 to 42 per 100,000 person-year among women, and from 11 to 73 per 100,000 person-year among men, exceeding the rate of increase of invasive melanomas. Melanoma mortality initially increased during the follow-up period then plateaued. Men were more likely than women to develop in situ melanomas on the upper half of the body (P<.001). Invasive melanomas were diagnosed at a younger age than MIS (P<.001), and were more likely to be found on the lower extremities than MIS (P<.001). This is a strictly descriptive study without examination into mechanisms. We found epidemiologic and clinical differences for in situ and invasive melanomas, which support further examination into the variations in etiologic pathways. The lack of improvement in mortality despite the increase in detection of in situ relative to invasive lesions further highlights the need to improve invasive melanoma-specific clinical screening features.

Melanoma Review: Epidemiology, Risk Factors, Diagnosis and Staging

<i>Study Aim: </i>Cutaneous melanoma accounts for approximately 4% of all skin cancers diagnosis each year in the USA but is responsible for 75% of skin cancer deaths. Physicians need to have an up to date knowledge about the epidemiology, risk factors, and clinical features of melanoma in order to make an early diagnosis and provide appropriate management decisions to improve survival in this aggressive malignancy. We will be presenting an extensive, up to date, literature review of cutaneous melanoma including the epidemiology, risk factors, diagnosis and staging. <i>Method: </i>An extensive literature review was performed using the following search engines: Pubmed, Ovid, Miromedex, and Dynamed. We limited our literature search to research papers written in English using the following keywords: cutaneous melanoma, epidemiology of melanoma, risk factors for melanoma, diagnosis of melanoma, clinical classification and staging of melanoma. <i>Results: </i>As a result of our extensive literature review we present an up to date review on the epidemiology, pathogenesis, risk factors, diagnosis, classification and staging of cutaneous melanoma. <i>Conclusion: </i>Physicians need to have an up to date knowledge about the epidemiology, risk factors, and clinical features in order to make an early diagnosis and provide appropriate management decisions in order to improve the survival patients with this aggressive malignancy.

Clinical and histopathological characteristics in relation to aetiological risk factors in cutaneous melanoma: a population-based study.

In this population-based, case-control study from Sweden using data collected from 1988 to 1990, an increased risk of melanoma was associated with the number of sunburns, propensity to freckle, the number of raised naevi and a family history of melanoma. Furthermore, a decreased risk was associated with occupational sun exposure. The purpose of this study was to investigate whether different histopathological features of the melanoma and clinical factors were related to the different aetiological risk factor patterns. All the confirmed primary cutaneous melanomas (n = 366) were included in the study. Both univariate analyses with tests for interaction and multivariate analyses were performed. Patients with melanoma on the trunk and patients with thin melanomas had an excess of close relatives with a history of melanoma (odds ratios [ORs] = 2.7 and 2.3, respectively). A relationship was also seen between melanomas in younger persons and a family history of melanoma (OR = 2.6). The presence of raised naevi on the arm had a tendency to be closer related to melanoma of the nodular type (OR = 4.3) than melanoma of the superficial spreading type (OR = 1.6). Patients with outdoor occupations during summer had a decreased risk of developing melanoma on the extremities. Melanoma diagnosed in patients born before 1939 had an association with sunburns (OR = 1.9) and freckling (OR = 2.0), while melanomas in patients born in 1939 or later were related to a family history of melanoma (OR = 2.2). These results suggest that different histopathological and clinical features of melanoma are associated with different risk factor patterns, which may imply diverging tumour genesis.

Avoiding sampling error in the biopsy of pigmented lesions

PREVENTION AND early detection are the most important interventions in decreasing the morbidity and mortality rates of cutaneous melanoma. The public health problem posed by melanoma is already significant and continues to grow rapidly. Fortunately, education of patients and physicians about clinical features of melanoma, such as the appearance of a new dark spot on the skin, a changing mole, and the ABCs of melanoma, has led to increased awareness about pigmented lesions in general. 1-4 Nevertheless, a significant number of individuals still have yet to even hear of the term melanoma and fewer still are aware of the clinical appearance of these lesions. 5 Given the increasing incidence of this dangerous neoplasm, it is sure to continue to cause significant morbidity and mortality for years to come. Although dermatologists are taught that the identification of cutaneous melanoma on clinical inspection is generally straightforward, it may be difficult, if not