Clinical Features Of Infectious Mononucleosis Research Articles

Childhood infectious mononucleosis

Epstein-Barr virus (EBV) is a human herpesvirus that is ubiquitous in nature, and most of the world population is infected by it. Infectious Mononucleosis (IM) is the most common clinical syndrome caused by EBV. This study was conducted to valuate epidemiological and clinical features of Infectious Mononucleosis caused by EBV in children. In it were enrolled 107 children 0-14 years old hospitalized with the diagnosis of Infectious Mononucleosis. Children ranged from 8-months old to 12.5years old, median age was 4.74 years. Fever was the most prominent feature in 97% of cases followed by lymphadenitis and pharyngitis in 79% and 78% of cases. Hepatitis was found in 55% of children. Classic syndrome of Infectious Mononucleosis was more prevalent in older children. Conclusively the probability of developing Infectious Mononucleosis after primary EBV infection correlates with age, young children are often moderately ill, presenting with atypical or partial Infective Mononucleosis syndrome.

Clinical Characteristics and Empirical Research Model of Infectious Mononucleosis Complicated with Mycoplasma pneumoniae or/and Cytomegalovirus Infection.

To study the clinical features of infectious mononucleosis (IM) caused by Epstein-Barr virus (EBV) mixed with Mycoplasma pneumonia (MP) or/and cytomegalovirus (CMV)infection, collected 201 hospitalized children who met the IM diagnostic criteria, the clinical manifestations, laboratory tests, complications, treatment, and outcome were compared among EBV infection alone and EBV mixed with MP or/and CMV infection. Most of the children with IM were preschoolers, more frequently occurred in boys than girls. EBV patients with MP had the longest duration of fever. When mixed pathogen infections were involved, the white blood cell count of preschool children was significantly increased, while splenomegaly was more common in older children. In the cases of EBV infection alone, abnormal liver function was positively correlated with age (P = 0.044). Mixed pathogen infections were more common in children with IM, occurring in all age groups, and some clinical characteristics were related to the age of onset and the pathogen of the infection.

Clinical features of infectious mononucleosis in children, depending on the etiological factor

Objective: The objective is to analyze clinical and laboratory features of infectious mononucleosis (IM) depending on disease etiology.Methods: 102 children with IM aged from 1 to 15 y.o. were examined. Polymerase chain reaction and immunoenzyme method were used to verify disease etiology.Results: In patients with Epstein–Barr virus and mixed infection, the most pronounced manifestations of lymphoproliferative syndrome and tonsillitis, high content of atypical mononuclear cells in peripheral blood are detected. Aspects of IM of cytomegaloviral etiology were notable for the prevalence of toxic syndrome along with other less pronounced clinical and laboratory manifestations of the disease.Conclusions: The detected features of the aspects of IM depending on etiological factor allow to prognosticate a variant and a character of the disease course and to early improve the therapy.

A Case of Infectious Mononucleosis-like Syndrome Induced by Ceftriaxone and Isepamicin in a Patient with Systemic Lupus Erythematosus

A severe adverse reaction to certain drug could be associated with hypersensitivity syndrome, showing the clinical features of infectious mononucleosis including maculopapular rash, fever, lymphadenopathy, leukocytosis, atypical lymphocytes, liver dysfunction, and renal disturbance. We report a systemic lupus erythematosus patient who developed infectious mononucleosis-like syndrome with administration of ceftriaxone/isepamicin for the treatment of pneumonia. This case warrants careful attention to infectious mononucleosis-like syndrome associated with antibiotics administration, especially in febrile patients with known autoimmune diseases such as systemic lupus erythematosus.

Epstein-Barr Virus

1. Anne K. Junker, MD* 1. *Associate Professor, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia and Children’s & Women’s Health Centre of British Columbia, Vancouver, BC, Canada Author Disclosure Dr. Junker did not disclose any financial relationships relevant to this article. After completing this article, readers should be able to: 1. Outline the epidemiology of primary Epstein-Barr virus (EBV) infection. 2. Describe and explain the physiologic basis of the clinical features of infectious mononucleosis. 3. Describe and explain the physiologic basis of the common complications of infectious mononucleosis. 4. List the diagnostic tests that can help distinguish acute primary from distant past EBV infection. 5. Review the EBV-associated lymphoproliferative disorders and malignancies. EBV was identified initially in 1964 in tumor tissue from a patient who had African Burkitt lymphoma (BL), a rapidly growing, usually fatal malignancy of the B lymphocyte. When a laboratory technician working with this new virus became ill with mononucleosis and seroconverted to EBV, the link between EBV and mononucleosis became apparent. Soon thereafter, seroepidemiologic studies revealed that EBV infects virtually all of the world’s population, usually as a subclinical or trivial illness in childhood. A decade later, reports of a familial X-linked disorder of fatal infectious mononucleosis highlighted the importance of immunogenetic factors in the management of EBV infection. Now, nearly 40 years after its discovery, EBV continues to captivate clinicians, virologists, oncologists, geneticists, and immunologists attempting to understand this highly successful human pathogen. EBV is a ubiquitous, worldwide pathogen that is harbored persistently by virtually all adults, regardless of geographic location. After primary infection, the virus latently infects circulating B cells and is shed silently into saliva and genital secretions. The colloquial term “kissing disease” acknowledges the oral route by which most people are infected. Spread is associated with close personal contact, so it is not surprising that the age at first infection varies according to living conditions. Infection occurs at an earlier age in the presence of poor hygiene and crowded living conditions; infection rates in …

Pseudoinfectious mononucleosis: a presentation ofBartonella henselae infection

Six children presented during one year with clinical features of infectious mononucleosis, but with laboratory findings of leucocytosis with neutrophilia, increased erythrocyte sedimentation rate, and hypergammaglobulinaemia. Serology for Epstein–Barr virus,...

Severe optic neuritis in infectious mononucleosis

Because the presentation and clinical features of infectious mononucleosis can be misleading in the elderly, a significant number of infections may go unrecognized. We report an unusual case of infectious mononucleosis in a 61-year-old man in whom marked visual impairment was the presenting complaint and severe optic neuritis was the only prominent finding. Confirmation of the diagnosis was made by serologic testing for Epstein-Barr virus antibody. Recovery of visual function was near complete, but optic atrophy persisted. We reviewed the English literature and collected seven cases of well-documented optic neuritis associated with infectious mononucleosis. A clinical profile of parainfectious optic neuritis is discussed along with the likely pathogenesis for this complication.

Mediastinal Lymphadenopathy in Infectious Mononucleosis

ENLARGEMENT of lymph nodes in the neck almost invariably forms an integral part of the clinical features of infectious mononucleosis. When the lymphadenopathy is accompanied by sore throat and splenomegaly, the diagnosis of infectious mononucleosis is quite likely, but must be confirmed by specific laboratory examinations. The fact that<i>mediastinal lymph nodes</i>can be involved in this disease may be overlooked by the internist, since many patients with infectious mononucleosis do not have chest xray films taken. This article describes two patients with proved mononucleosis in whom marked mediastinal lymphadenopathy developed during the course of their disease. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 20-year-old soldier was admitted with sore throat, cough, and abdominal pain. Physical examination disclosed bilaterally enlarged cervical glands and mild hepatosplenomegaly. Laboratory data included a white blood cell count of 14,300/cu mm with 71% lymphocytes, most of them atypical. A chest x-ray film showed widening of the

Infectious Mononucleosis and Epstein Barr Virus in Childhood

The Epstein-Barr virus (EBV) antibody titer was examined in 22 children whose atypical mononuclear cells appeared in the peripheral blood smear. Paul-Bunnell and mononucleosis tests were negative in all these children, but antibodies to EBV were demonstrated in 21 of them. Only five children in a control group of 27 had antibodies to EBV. We conclude that the presence of EBV antibodies with a rising titer supports a diagnosis of infectious mononucleosis. It is of particular importance in children under 1 year of age in whom the finding of atypical mononuclear cells in the absence of positive Paul-Bunnell and mononucleosis tests shows a strong correlation with EBV antibody titer. This finding frequently occurs in the absence of typical clinical features of infectious mononucleosis.

Involvement of the Central Nervous System in Infectious Mononucleosis

INFECTIOUS mononucleosis is generally regarded as a benign disease having a uniformly good prognosis. In the majority of cases this belief is substantiated, but in occasional cases this disease causes permanent damage and sometimes seriously threatens life. The clinical features of infectious mononucleosis have been described in detail1 2 3 4 5 6 and there are numerous articles on the hematological findings.1 , 2 , 5 , 7 8 9 10 There have, however, been relatively few reports dealing with the abnormalities of the central nervous system sometimes encountered. The first case of involvement of the central nervous system in infectious mononucleosis was reported by Johansen11 in 1931. His patient presented meningismus, drowsiness, impaired . . .