Background: There is conflicting data regarding the kinds, amounts, lengths, and methods of burnout therapies, as well as how clinical nurses rate their own burnout. The purpose of this study was to assess clinical nurses' burnout interventions. Method: This study examines the benefits of burnout reduction strategies for clinical nurses through a comprehensive review. We followed the PRISMA guidelines' suggestions. In order to obtain results that appropriately represented the effects of burnout therapies, we selectively included research published between 2019 and 2024. A work written entirely in English. Search engines from the Cochrane Library, CINAHL, PubMed, and Scopus were used. Result: Six studies were considered in this systematic review, of which two were interventional studies and four were randomized controlled trials. There were studies done in China, Turkey, Iran, Spain, and Saudi Arabia. A workshop on burnout prevention, stress-coping and cognitive behavioral therapy, emotional freedom strategies, emotional regulation training, and a mindfulness training program are some of the interventions that are used. Among the burnout metrics employed were Pines & Aronson, MBI, and ProQoL. There were 337 nurses in all in the interventional groups and 324 in the control groups. Conclusion: Burnout was successfully decreased by a mindfulness training program, emotional freedom techniques, emotional regulation training, stress-coping and cognitive behavioral therapy, and a burnout prevention course.