Effective Climate Change (CC) adaptation strategies for biodiversity conservation have been heavily discussed recently. Currently, there are ∼650 CC adaptation recommendations such as managing healthy vegetation on slopes (Veech, 2003), terrestrial and inland water systems (Settele et al., 2014), landscape restoration efforts (Pradhan and Shrestha, 2007), creation and protection of climate refuges (Lindenmayer et al., 2010), wildlife conservation (Mawdsley et al., 2009) among several others (Grabherr, 2009; Khattak et al., 2010). However, they are vague, lack specific solutions with limited analysis of significant benefits, advantages and disadvantages. Over the last few years, I have been developing a database which critically evaluates a variety of CC adaptation strategies, for several biodiversity conservation scenarios. After performing extensive analysis of the existing recommendations, and comparing them against the database that I have been populating, I have critically identified and analyzed 13 effective adaptation strategies for biodiversity conservation that confer significant ecological benefits, and therefore, I discuss them here as most effective. They are segmented under [1] identification and analysis of existing stressors, [2] initiation of strategic zoning of land uses, [3] better preparation for major disturbances, [4] identification and designation of reserves, and [5] increased communication of knowledge to stakeholders. Intended benefits of such adaptation strategies include [a] improved capacity of decision makers to adapt to CC; [b] ability to adapt CC with specific reference to the interactions between ecosystems, communities and populations; [c] ability to device most appropriate adaptation strategies for different CC scenarios; [d] increased flow of communication; [e] ability to device proactive adaptive strategies for different habitat; [f] establish cross-national collaboration among the organizations; [g]ability to develop guidelines for adapting to CC that is specific for regions prone to extremities of stress, and [h] quantify environmental susceptibility against adaptive capacity, for effective biodiversity conservation (see Table 1).