Lymphogranuloma Inguinale Research Articles

Awareness on Intradermal Injection among Dentists

An intradermal injection may be given for diagnostic purposes checking for allergy, lymphogranuloma inguinale or tuberculosis and for treating diseases like vitiligo. Due to the limited blood supply of that skin layer, medication injected into the dermis is absorbed slowly. The aim of the study is to determine the level of knowledge and awareness on the use of intradermal injection in dental practice by the dentists. The study was formulated as a questionnaire-based observational study comprising 100 participants. All the subjects were requested to respond to a list of questions regarding the intradermal injections and their use in dental practice by the dentists. More than 88% of the dentists are aware of the intradermal injection and they prefer them during the clinical practice for diagnostic purposes. The intradermal injection of lidocaine reduces the pain in patients and dentists are aware of its use in dental practice.

Sarcoidosis of the female genital tract: a case presentation and survey of the world literature

Sarcoidosis of the female genital tract is a rare clinical entity with only 20 cases reported in the world literature to date. An additional case is presented with a review of the previously reported cases. The diagnostic and histologic aspects of the disease are also discussed. The presence of granulomatous diseases in the female genital tract should initiate a thorough investigation for potential etiologies by both the pathologist and clinician. Etiologies of granuloma fraction must include coccidiomycosis, foreign body reactions, lymphogranuloma inguinale, and tuberculosis. Bacteriologic proof is essential to differentiate these from sarcoidosis.

The establishment of lymphogranuloma inguinale (lymphopathia venereum) as a sexually transmitted disease.

The establishment of lymphogranuloma inguinale (lymphopathia venereum) as a sexually transmitted disease.

Tropical Diseases, ed 4.

The idea of having a separate supplement to a textbook of medicine may not be a good one, if the supplement is too brief. Nevertheless, this has been the case since 1964 in Tropical Diseases: Supplement to the Prin- ciples and Practice of Medicine . This supplement is intended primarily for students and general practioners living in the tropics (it is not comprehensive enough for those who are interested in tropical diseases). It represents a synopsis of the diseases seen in the tropics, but not necessarily limited to the tropics. Many of them, as a matter of fact, have worldwide distribution: toxoplasmosis, giardiasis, anthrax, tularemia, ratbite fevers, trachoma, superficial mycosis, and histoplasmosis (hemorrhagic disease with renal syndrome is not a tropical disease by any means). Although the new addition has been revised and updated, some areas remain neglected. For instance, the agent causing lymphogranuloma inguinale is neither large virus nor rickettsia;

Therapy of lymphogranuloma inguinale with 17,025.

The search for effective anti-viral agents continues in many laboratories in a number of countries. A clinical trial of 7218 (2:3 dimethyl quinoxaline dioxide) in lymphogranuloma inguinale 8 years ago (Alergant, 1953) showed that although the drug was therapeutically active, toxic side-effects prevented its being regarded as a useful addition to the pharmacopoeia. Although of no value in the treatment of lymphogranuloma it is interesting to note that, despite its potential toxicity, it shows promise in quite an unexpected field, as a life-saving drug in antibiotic-resistant Ps. pyocyanea infections. Hurst and Hull (1961) working in the laboratory which produced 7218 (Hurst, Landquist, Melvin, Peters, Senior, Silk, and Stacey, 1953) have recently described the anti-viral activity of a newly synthesized compound, provisionally termed 17,025 (5 methoxy carbonyl 6 methyl 4 (5 nitrofuryl) 2 oxy 1:2:3:4: tetrahydropyrimidine), against infections with viruses of the psittacosis-lymphogranuloma-trachoma group both in mice and in the developing chick embryo. They made an exhaustive comparison of its activity in relation to antibiotics and to other synthetic compounds known to act against these viruses, and they found the compound equally active against two strains of psittacosis, two of lymphogranuloma, three of trachoma, and two of inclusion blennorrhoea. The drug was essentially non-toxic and, when injected intramuscularly, produced no immediate or delayed ill-effects. Although weight for weight only a tenth or a twentieth as active as aureomycin, its very sparing solubility brings it into the category of a repository drug; in favourable circumstances a single injection of a suspension in arachis oil was found to be capable of controlling completely a virulent psittacosis infection in a majority of mice.

Inclusion bodies in trachoma.

THE epithelial-cell inclusion, which is characteristically found in the early stages of trachoma was first described by Halberstaedter and Prowazek (1907). Since that time, a considerable literature concerning the nature of these has accumulated. It is generally conceded that they consist of virus particles together with material elaborated by the virus and/or produced by the parasitized cell as a result of interference with its metabolism. The concept of developmental phases in the life-history of the inclusion body was first described by Lindner (1910). At an early stage the inclusion body is composed of larger particles (06 16 ,u) staining dark blue with the Giemsa mixture-the initial -which are associated with a basophilic matrix-the so-called plastin material of Halberstaedter (1912). The initial are considered to fragment in some way, thereby giving rise to the smaller particles called bodies (0-25 4u), which stain in a manner similar to that of nuclei with the Giemsa mixture, i.e. magenta-red ( Romanowsky effect ). Lindner's observations have in general been confirmed by those of Thygeson (1934a), and have received indirect support from the parallelism afforded in the maturation stages described for the inclusion body in inclusion conjunctivitis (Thygeson, 1934b), and also by the somewhat similar cyclical changes described for the inclusion in psittacosis (Bedson and Bland, 1932; Bland and Canti, 1935), and lymphogranuloma inguinale (Findlay and others, 1938). Indeed it is largely because of this similarity in the pleomorphism of their inclusion that the large viruses of these four diseases are grouped together taxonomically. Rice (1936) and later Thygeson (1938) demonstrated the presence of a carbohydrate matrix in which the virus particles lie; using histochemical methods they identified this substance as glycogen. Grossfeld (1950), using the Feulgen technique, found the elementary to contain desoxyribose nucleic acid (this author considered the initial and elementary to be similar in nature, differing essentially only in size and in their degree of basophilia). In this present study, histochemical methods were used to demonstrate both types of nucleic acids (desoxyribose nucleic acid (D.N.A.) and ribose nucleic

The treatment of climatic bubo (lymphogranuloma venereum) in the African Negro

Journal Article The treatment of climatic bubo (lymphogranuloma venereum) in the African Negro Get access R. R. Willcox, M.D. R. R. Willcox, M.D. St. Mary's Hospital, W.2. Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 46, Issue 6, November 1952, Pages 658–661, https://doi.org/10.1016/0035-9203(52)90027-8 Published: 01 November 1952

Lymphogranuloma inguinale in children: report of 2 cases.

SummaryReport of two new cases of lymphogranuloma inguinale (lgrl. venereum) in young girls — 13 and 14 years old — with severe rectal strictures. These are the 8th and 9th cases of lymphogranuloma inguinale in children seen in Finland. Both children wore probably infected by their mothers, who were suffering from the same disease with rectal manifestations.

AUREOMYCIN IN TREATMENT OF EXPERIMENTAL AND HUMAN TULAREMIA

The new antibiotic, aureomycin, first described by Duggar, 1 has been shown to exert specific effect when administered to patients suffering with diseases caused by gram-negative 2 and certain gram-positive organisms. 2b Detailed reports of its usefulness in rickettsial infections have now been recorded, and aureomycin perhaps exerts its greatest influence in this group of diseases. 3 Favorable results from its employment in lymphogranuloma inguinale have been published. 4 No toxic effects other than nausea and occasional diarrhea attributable to the drug have been observed in our experience or in the patients who have been treated with this agent and reported in the medical literature. We have been interested in the chemotherapy of tularemia since 1947, when para-aminobenzoic acid (PABA) was observed by us to exert slight benefit in mice experimentally infected with Bacterium tularense. This effect, however, did not in any way approach that achieved with streptomycin, but in

Simplified Penicillin Treatment of Lymphogranuloma Inguinale and other Venereal Diseases in West African Troops

Simplified Penicillin Treatment of Lymphogranuloma Inguinale and other Venereal Diseases in West African Troops

The Estrogen Treatment of Stricture of the Rectum Due to Lymphogranuloma Venereum1

CLINICAL observations noted accidentally may lead to new and important therapeutic conceptions. The treatment of stricture of the rectum due to lymphogranuloma venereum has, until the present time, been highly unsuccessful. The observation that a stricture of this type improves tremendously during pregnancy and renders the patient free from symptom after delivery stimulated the search for the explanation of this phenomenon. This report of four cases will serve to indicate the beneficial and almost specific effect of estrogens in alleviating rectal strictures of this type. Lymphogranuloma inguinale or lymphopathia venereum (9) is a wide spread communicable disease usually acquired venereally. It affects all races but is especially common in the colored race. It occurs in both males and females and gains entrance through the skin and mucous membranes. The disease is believed to be due to a filterable agent (2) and is diagnosed by a positive Frei test (1) and a positive complement fixation test (8).

VIRUSES AND VIRUS DISEASES OF EYE

LYMPHOGRANULOMA VENEREUM In 1913 Durand, Nicolas and Favre 116 published the first comprehensive description of lymphogranuloma venereum, which had previously been confused with tuberculosis, syphilis and other diseases. In 1925 Frei 117 described the intradermal test which bears his name, in which an antigen prepared by sterilizing pus from unruptured buboes of lymphogranuloma venereum produces in persons who have or who have had the disease a specific inflammatory reaction. In 1930 Hellerstrom and Wassen 118 demonstrated that the causal agent is a filtrable virus. Lymphogranuloma venereum, also known as lymphogranuloma inguinale or lymphopathia venerea (um), is primarily a disease of the lymphatic system. In the male the principal lesion is inguinal adenitis ; in the female the characteristic lesions are elephantiasis of the external genitalia and chronic ulceration of the vulva, peritoneum, anus or rectum, leading to fistula and rectal stricture. A large number of extragenital manifestations have been described. Among

LYMPHOGRANULOMA INGUINALE: AUSTRALIAN RECORDS

Medical Journal of AustraliaVolume 1, Issue 14 p. 309-309 Correspondence LYMPHOGRANULOMA INGUINALE: AUSTRALIAN RECORDS First published: 01 April 1943 https://doi.org/10.5694/j.1326-5377.1943.tb44374.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume1, Issue14April 1943Pages 309-309 RelatedInformation

LYMPHOGRANULOMA INGUINALE: HISTORICAL REVIEW AND PATHOLOGICAL ASPECTS

Medical Journal of AustraliaVolume 1, Issue 2 p. 23-25 Original Article LYMPHOGRANULOMA INGUINALE: HISTORICAL REVIEW AND PATHOLOGICAL ASPECTS† H. P. Bettinger, H. P. Bettinger Department of Pathology, Women's Hospital, MelbourneSearch for more papers by this author H. P. Bettinger, H. P. Bettinger Department of Pathology, Women's Hospital, MelbourneSearch for more papers by this author First published: 01 January 1943 https://doi.org/10.5694/j.1326-5377.1943.tb51064.x †Part of a symposium held at a meeting of the Victorian Branch of the British Medical Association on August 5, 1942. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume1, Issue2January 1943Pages 23-25 RelatedInformation

MENINGOENCEPHALITIS IN MAN CAUSED BY THE VIRUS OF LYMPHOGRANULOMA VENEREUM

Our purpose in this communication is to present data establishing the virus of lymphogranuloma venereum as a cause of severe meningoencephalitis in man. The capacity of the causative agent of venereal lymphogranuloma (lymphogranuloma inguinale, lymphopathia venerea, Nicolas-Favre disease, climatic bubo, fourth venereal disease) to produce meningoencephalitis after intracerebral inoculation in susceptible experimental animals has been known since the virus was first isolated and identified in 1930.¹However, even in experimental animals meningoencephalitis was not known to occur after inoculation of the virus by peripheral routes without simultaneous trauma to the brain.²Signs and symptoms suggestive of involvement of the nervous system during the course of lymphogranuloma venereum in man have been recorded by many observers.³Von Haam and D'Aunoy⁴isolated from the cerebrospinal fluid of 2 out of 8 patients with lymphogranuloma venereum viruses which produced meningoencephalitis in mice. These viruses were identified as lymphogranuloma venereum

HODGKIN'S LYMPHOGRANULOMA (RECTAL STRICTURE); REPORT OF A CASE

Case Reports1 August 1942HODGKIN'S LYMPHOGRANULOMA (RECTAL STRICTURE); REPORT OF A CASEMANUEL G. SPIESMAN, M.D., HYMAN I. RUBENSTEIN, M.D.MANUEL G. SPIESMAN, M.D.Search for more papers by this author, HYMAN I. RUBENSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-2-349 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHISTORICALPrevious to Schlagenhaufer's report of a primary case of Hodgkin's disease of the gastrointestinal tract in 1913 it was a generally accepted rule that the gastrointestinal tract was immune to this disease. Today the literature on this subject and our personal experience make it possible for us to assume that some cases grossly diagnosed as gastric carcinoma, gastric ulcer, enterocolitis, tuberculosis, lymphosarcoma, obstruction of the colon, and carcinoma and syphilis of the rectum may have been intestinal or rectal Hodgkin's disease.Even though primary and secondary gastrointestinal Hodgkin's disease is definitely known to exist, the meager literature emphasizes the...Bibliography1. CRAVER LF: Local and general irradiation in Hodgkin's disease, Radiology, 1938, xxxi, 42-47. CrossrefGoogle Scholar2. DAVID VC: Pseudo-carcinoma of stomach resembling carcinoma, Ann. Surg., 1928, lxxxvii, 555-565. CrossrefGoogle Scholar3. GOLDFARB SJ: Hodgkin's disease of the gastrointestinal tract, Mt. Sinai Hosp. Bull., 1937, iv, 298-303. Google Scholar4. GALLANTDE VINALS MPR: Lymphogranuloma de Hodgkins rectale de forme tumorale, Arch. d. mal. app. digest., 1938, xxviii, 67-73. Google Scholar5. HOLMESDRESSERCAMP GWRJD: Lymphoblastoma; its gastric manifestations, with special reference to roentgen findings, Radiology, 1926, vii, 44-50. CrossrefGoogle Scholar6. LUBARSCH O: Ueber Lymphogranulomatose, Berl. klin. Wchnschr., 1918, lv, 708-710. Google Scholar7. NEIMAN B: Personal communication (Former Pathologist Cook County Hospital, Chicago). Google Scholar8. RUGGLESSTONE HERS: Lymphoblastoma involving stomach, roentgenologically considered, California and West Med., 1930, xxxiii, 486-490. Google Scholar9. SINGER HA: Primary, isolated lymphogranulomatosis of the stomach, Arch. Surg., 1931, xxii, 1001-1017. CrossrefGoogle Scholar10. SUSSIG L: Intestinal type of lymphogranulomatosis, Med. Klin., 1924, xx, 415-416. Google Scholar11. SCHLAGENHAUFER F: Ueber Granulomatosis des Magendarmtrakts, Zentralbl. f. path. Anat., 1913, xxiv, 965-966. Google Scholar12. SHERMAN ED: Gastrointestinal manifestations of lymphogranulomatosis (Hodgkin's disease), Arch. Int. Med., 1938, lxi, 60-82. CrossrefGoogle Scholar13. SPIESMAN MG: Lymphogranuloma inguinale, rectal stricture and prestricture, Am. Jr. Digest. Dis. and Nutrition, 1937, iii, 931-936. Google Scholar14. SYMMERS D: Certain unusual lesions of the lymphatic apparatus, Arch. Int Med., 1909, iv, 218-237. CrossrefGoogle Scholar15. TERPLAN K: Ueber die intestinale Form der Lymphogranulomatose, Virchow's Arch. f. path. Anat., 1922, ccxxxvii, 241-264. CrossrefGoogle Scholar16. WELLSMAVER HGMB: Pseudoleukaemia gastrointestinalis, Jr. Am. Med. Assoc., 1904, cxxviii, 837-855. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication December 3, 1940.From the Department of Proctology of the Surgical Service of the Mt. Sinai Hospital, Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1942Volume 17, Issue 2Page: 349-358KeywordsColonEnterocolitisGastric ulcersGastrointestinal tractHodgkin lymphomaRectumSyphilis ePublished: 1 December 2008 Issue Published: 1 August 1942 PDF downloadLoading ...

A Case of Lympho-Granuloma Inguinale producing Rectal Stricture

A case of rectal stricture of recent onset occurring in a middle-aged woman. Other symptoms include marked loss in weight, pyrexia and, at one time, symptoms suggesting an acute abdominal condition. Clinical and X-ray findings revealed a stricture of the rectum. The association of enlarged lymph nodes, peri-anal suppuration and a strongly positive Frei test leads one to a diagnosis of lymphogranuloma inguinale. My thanks are due to Mr. C. A. Horder and Dr. W. Addey for their kind permission to publish this case.

Digestive tract infection by the virus of lymphogranuloma inguinale

Digestive tract infection by the virus of lymphogranuloma inguinale

Lymphogranuloma venereum in the female

YMPHOGRANULOMA venereum now L seems to be the acceptabIe name for a disease with so many appelIations as to confuse even workers in the fieId of venerea1 disease. Four years ago we described some urethral Iesions as“Iymphopathia venereum,“l a term originated by WoIf and SuIzberger.” This seemed to be a superior term. However, since the CumuIative Index now Iists this as IymphogranuIoma venereum, the future Iiterature should be correlated under this titIe. Among many other names this disease was caIIed tropical or climatic bubo. The most wideIy known name in recent years has been IymphogranuIoma inguinaIe. It was 0riginaIIy appIied by Durand, NicoIas and Favre3 in 1913 to chronic inguina1 adenitis with muItipIe draining sinuses. The term was applied because of an apparent microscopic simiIarity with Hodgkin’s disease I,,“ Iymphogranuloma “), The study of this condition progressed littIe or none unti1 1923, when Frei4 discovered the diagnostic properties of an antigen prepared from the bacteriologically sterile pus removed from buboes. This important skin test gave impetus to worId wide studies and a tremendous Iiterature has deveIoped. Many obscure Iesions quite unconnected with the inguina1 adenitis have now been brought together. The disease has been transferred to monkeys and to mice (HeIIerstriim and Wass!m,5 and others), producing characteristic meningitis after intracerebrar inocuIation; to guinea pigs (Meyer, RosenfeId and Ander$) producing a typica inguina1 adenitis after inocuIation in the groin; and to other animals. The fiIterabIe virus nature of the causative agent has been made cIear by a number of investigators. It has been cultured on tissue-Tyrode media by Tamura.7 The entity of this virus disease is undisputed at the present time.

The Neutralization Test in Lymphogranuloma Venereum

The neutralization test has proven a highly important aid in the recognition and epidemiological study of numerous virus diseases. In lymphogranuloma venereum as well, this test should be distinctly valuable, especially in those cases where it is not possible or practicable to perform the Frei test or where there is anergy or a doubtful skin reaction. Unfortunately, however, the literature on this subject, as in many of the experimental phases of this disease, is contradictory. Levaditi and his coworkers,1 to whom we owe much of the pioneer work in lymphogranuloma venereum, first reported successful neutralization experiments using the monkey as test animal in 1931. In the following year, they2 obtained positive results with the mouse. Also in 1932, Findlay3 successfully employed this test and by means of it, was able to establish the identity of climatic bubo and lymphogranuloma venereum. Wassin, in 1935, not only obtained positive results by means of the intracerebral neutralization test in mice, but devised a new intradermal test in the guinea pig. Miyagawa6 and his coworkers confirmed these observations. More