This article is devoted to assessing the bioclimatic conditions of the most popular route among foreign tourists in Uzbekistan – Tashkent-Samarkand-Bukhara-Khiva based on statistical processing of meteorological observation data for the period 2011-2020 and the use of the thermohygrometric coefficient of air dryness (THC) and Missenard’s Effective Temperature (ET). Climatic descriptions of the cities of Tashkent, Samarkand, Bukhara, and Khiva include information on the regime of air temperature, precipitation, air humidity, and cloudiness, which were used to compile the Climate-Tourism-Information-Scheme (CTIS). The results obtained show that in the cities under study, there are two seasons with the most favorable thermal comfort conditions throughout the year. In Tashkent, these are the periods April-May and September-first ten days of November, in Samarkand – March-June and September-October, in Bukhara – April-May and September-October, and Khiva – from the second ten days of April to June and from the third ten days of August to the second ten days of October.
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