This paper analyses how EU regions have aligned their innovation and policy endeavours to tackle exposure to the effects of Climate Change at regional level. Scholars hailed the need to orienting efforts and resources to tackle societal challenges. However, we have little empirical evidence on the alignment of R&I ecosystems and policy endeavours towards tackling Climate Change. Using regression analysis, we assess the relationship between such directionality and the exposure to risk of disasters (i.e., coastal floods, river floods, and landslides) that each region faces in the short, medium, and long term due to Climate Change. Results show a positive relationship between risk projection and climate change preparedness. However, a more in-depth analysis demonstrates the complexity of such geographical "problem-solution convergence": investigating whether the EU regions most at risk of being affected by climate change are also the ones most ready to target climate change through an aligned combination of R&I and policy efforts. Findings show that more developed regions appear more ready to tackle climate change effects compared to transition and less developed regions. These findings suggest that more support is needed for less developed regions facing major Climate Change-related risks.