A generalized water retention curve (WRC) model in a wide suction range considering the initial void ratio is presented in this paper. Both capillary and adsorbed water in soil pores are considered. Based on the experimental results that the adsorbed water content wa is not dependent on the initial void ratio, a new degree of saturation equation of adsorbed water is established. Meanwhile, a new degree of saturation equation of capillary water at various initial void ratios is proposed with a void ratio-related expression of the air entry value. Compared to Lu’s model, only one parameter b is introduced in the established model, which can be easily calibrated using WRCs under two initial void ratios. The measured WRC results of 5 soils are used to verify the proposed model in comparison with the other 3 widely used WRC models. The soil used in the model validation covers a wide range of soil types from sandy soil to clay soil, including clayey silty sand, sandy clay till, clayey silt, expansive soil and lateritic soil. The proposed model is well verified for its ability to describe soil water retention characteristics in a wide suction range at various initial void ratios.