The vulnerability of clay brick masonry load-bearing (CBML) walls under low-intensity explosions has been extensively investigated. In recent years, large-scale explosions have raised wide concerns about the destructive effect of intense explosions. Intense explosions induced by large TNT equivalent explosives usually cause severe damage to building structures within several kilometers. Although the damage of building structures under intense explosions and normal low-intensity explosions might be different, the differences have yet received any attention in previous studies. Therefore, this study numerically investigates the dynamic performance of CBML walls under intense explosions with long duration (IELD). Firstly, the numerical model is validated by reproducing experimental records. Then the verified model is utilized to investigate the dynamic response and dynamic modes of CBML walls under IELD. Based on the identified failure mechanism, the effects of several parameters such as axial compression ratio, compressive strengths of masonry materials and wall geometry on the damage degrees of CBML walls are analyzed in detail. The damage index based on the residual axial loading capacity of CBML wall is proposed for damage evaluation. The damage assessment method is established for CBML walls under IELD, which can help to evaluate the damage level of clay brick masonry structures under far-field intense explosive scenarios.