In this paper, the Cauchy problem for the three-dimensional (3-D) isentropic compressible Navier-Stokes equations with degenerate viscosities is considered. By introducing some new variables and making use of the “quasi-symmetric hyperbolic”–“degenerate elliptic” coupled structure to control the behavior of the fluid velocity, we prove the global-in-time well-posedness of regular solutions with vacuum for a class of smooth initial data that are of small density but possibly large velocities. Here the initial mass density is required to decay to zero in the far field, and the spectrum of the Jacobi matrix of the initial velocity are all positive. The result here applies to a class of degenerate density-dependent viscosity coefficients, is independent of the BD-entropy, and seems to be the first on the global existence of smooth solutions which have large velocities and contain vacuum state for such degenerate system in three space dimensions.
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