The event-triggered predictor design problem for a class of nonlinear MIMO systems with large time delays is investigated in this paper. A periodic event-triggered mechanism is designed to avoid unnecessary data transmission and save communication energy. The triggering condition is only determined by sampled outputs of the system, such that it is applicable in case of the communication delay. Then a novel observer-based cascade predictor is proposed to reconstruct the original system state based on the delayed and event-triggered measurements, which is composed of a continuous-discrete observer and several sub-predictors in a chain structure. The stability of proposed predictor is analyzed through the Lyapunov approach. By using a sufficient number of sub-predictors and applying appropriate parameters, the prediction errors converge to bounded regions exponentially under large time delays. Finally, simulations are performed to verify the effectiveness of the proposed predictor and the event-triggered communication mechanism.