The primary aim of this paper is to investigate the asymptotic distribution of the zeros of certain classes of hypergeometric q + 1 F q polynomials. We employ classical analytical techniques, including Watson's lemma and the method of steepest descent, to understand the asymptotic behavior of these polynomials: q + 1 F q ( − n , kn + α , … , kn + α + q − 1 q ; kn + β , … , kn + β + q − 1 q ; z ) ( n → ∞ ) , where n is a nonnegative integer, q is a positive integer and the constant parameters α and β are constrained by α < β . By applying the general results established in this paper, we generate numerical evidence and graphical illustrations using Mathematica to show the clustering of zeros on certain curves.