Background: Psychological pathologies diagnosed during pregnancy are among the risk factors affecting adverse pregnancy outcomes. Objectives: This study aimed to determine the relationship between the prevalence of depression caused by antiphospholipid syndrome (APS) abortion and related factors in pregnant women. Methods: This research is a descriptive-analytical epidemiological study. Its target population includes all patients with abortions due to APS who referred to medical centers in Ahvaz city during the academic year from October 2022 to February 2023. Forty women with a history of at least two successful births and no history of fetal death or recurrent miscarriage, similar to the studied samples, were analyzed as a control group. Two demographic questionnaires—Midwifery and Beck's Depression—were used, and the data were analyzed using SPSS24 software. Results: The linear regression test showed a significant relationship between increasing maternal age, pregnancy rate, gestational age, history of depression, and increased depression caused by abortion (P < 0.05). There was a significant relationship between higher maternal education, higher husband's education, wife's occupation, mother's employment, number of living children, history of abortions, increased family well-being, and decreased depression caused by abortion (P < 0.05). Conclusions: It is recommended to implement a new consultation-based midwifery care method in maternity centers. Additionally, by enhancing follow-up and referral systems, individuals suspected of having mood disorders after abortion can be identified and referred to specialized centers.
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