Citrulline Malate Research Articles

Acute Effects of Citrulline Malate Supplementation on Nocturnal Blood Pressure Dipping After Exercise in Hypertensive Patients: A Randomized, Placebo-Controlled Trial

Background Citrulline malate (CM), especially when used in conjunction with physical exercise, has demonstrated potential as a non-pharmacological adjunct in the management of hypertension. Nevertheless, its impact on nocturnal blood pressure dipping remains unexplored. Objective Evaluate the impact of a single dose of CM on nocturnal blood pressure dipping after exercise in hypertensive individuals. Methods In a double-blind, placebo-controlled, parallel-group clinical trial, twenty hypertensive adults (55 ± 16 years) were randomly assigned to either a CM (6 g) or placebo (6 g of corn starch) group (PLA). Resting blood pressure was measured after a 20-min period of comfortable seating in a calm environment. Both groups underwent 40 min of treadmill running/walking at an intensity of 60–70% of their reserve heart rate, 120 min after ingesting the substances. Ambulatory blood pressure monitoring was employed to measure blood pressure over 24 h. Results No significant differences in systolic blood pressure values were observed between the CM and PLA groups at rest, during wakefulness, sleep, or over a 24-h period. However, CM exhibited a significant reduction in diastolic blood pressure in several metrics: delta 24 h (-14 mmHg vs −6 mmHg, p = 0.047), delta wakefulness (-12 mmHg vs −4 mmHg, p = 0.024), percent delta 24 h (-16% vs −6%, p = 0.024), and percent delta wakefulness (-14% vs −4%, p = 0.013). No significant differences were found between CM and PLA in terms of systolic and diastolic nocturnal absolute reductions (-13 mmHg vs −12 mmHg, p = 0.808, and −13 mmHg vs −8 mmHg, p = 0.273, respectively) or nocturnal percentage decrease (-9.9% vs −9.4%, p = 0.844, and −15.3% vs −11.7%, p = 0.399, respectively). Conclusions The study found no significant changes in the post-exercise nocturnal blood pressure dip following a single dose of CM supplementation. However, a notable reduction in diastolic blood pressure was observed during the waking period and over the average 24-h monitoring period. Clinical trial registry number and website ClinicalTrials.gov platform (NCT03378596).

Impact of citrulline malate supplementation on exercise performance and muscle regeneration

Background. A world of sport is filled with various types of supplements. For many years we have been searching for ways, to improve our strength and endurance. One of them is L-citrulline, witch is an endogenous amino acid, created from carbamyl and ornithine in the urea cycle. In the organism it is converted into arginine, and used during the cycle of transition into nitric oxide (NO). This mechanism probably can be associated with enhaced blood flow into muscle tissue, what can be helpful during both resistance and high-intensity exercise performance, and also during recovery of muscular performance.Material and methods. This article comprises a literature review based on publications from: PubMed, Clinicalkey, Journal of the International Society of Sports Nutrition, The Journal of Strength and Conditioning Research, Google scholar.Results. Citrulline malate is a sports supplement. However, the evidence base for its efficacy is still insufficient to permit clear conclusions to be drawn about its action.Conclusion. The substance citrulline malate increases the concentration of nitric oxide in the organism through numerous transformations. At present, it is not possible to state unequivocally whether this effect positively improves the function and efficiency of the muscular system, or whether it increases the efficiency of blood supply to organs and muscles. However, there are a large number of indications that, with the right dosage and supplementation regimen, we will be able to fully exploit the potential of this supplement as an aid to further sporting performance.

Effects of Acute Citrulline Malate Supplementation on CrossFit® Exercise Performance: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study.

Given the increasing popularity of CrossFit® as a high-intensity functional training program and the potential benefits of citrulline malate (CM) in enhancing exercise performance through its role as a precursor to L-arginine and nitric oxide production, this study aimed to investigate the acute effects of CM supplementation on CrossFit® performance and cardiovascular function. Using a randomized, double-blind, placebo-controlled, cross-over design, 21 recreationally active participants (mean age 22.2 ± 2.6 years, mean body weight 75.9 ± 10.4 kg) with CrossFit® experience completed the "Cindy" workout under CM and placebo conditions. Participants consumed 4.4 g of CM or a placebo 60 min before the workout, and the performance was measured by the number of rounds completed. Secondary outcomes included heart rate response, time spent in different heart rate intensity zones, and post-exercise recovery time. The results indicated no significant difference in the number of rounds completed between the CM and placebo conditions (13.5 ± 5.2 vs. 13.8 ± 6.7 rounds, respectively; p = 0.587). However, the time spent in zone 4 (80-90% of HR max) was significantly increased in the CM condition (527 ± 395 s vs. 453 ± 334 s; p = 0.017), suggesting a potential benefit for aerobic capacity and anaerobic threshold. No significant differences in post-exercise recovery time were observed (6.6 ± 4.7 h vs. 6.9 ± 4.7 h; p = 0.475). This study highlights the need for further research with larger sample sizes, both genders, and different CM dosages to clarify these findings and better understand CM's role in enhancing athletic performance.

The Effect of Citrulline Malate Supplement Applied in Addition to Fitness Trainings on Hormone Metabolism of Athletes

The Effect of Citrulline Malate Supplement Applied in Addition to Fitness Trainings on Hormone Metabolism of Athletes

Citrulline Malate Fails to Improve Repeated 300 m Swimming Times in Highly Trained Swimmers

Citrulline Malate Fails to Improve Repeated 300 m Swimming Times in Highly Trained Swimmers

The Acute Effect of Citrulline Malate Loading in Resistance Trained Males on: Anaerobic Muscular Endurance, Force Recovery and Muscle Soreness

The Acute Effect of Citrulline Malate Loading in Resistance Trained Males on: Anaerobic Muscular Endurance, Force Recovery and Muscle Soreness

Effects of Four Weeks of In-Season Pre-Workout Supplementation on Performance, Body Composition, Muscle Damage, and Health-Related Markers in Basketball Players: A Randomized Controlled Study.

This randomized, double-blinded, experimental study investigated the effects of a four-week daily pre-workout supplementation (200 mg caffeine, 3.3 g creatine monohydrate, 3.2 g β-alanine, 6 g citrulline malate, and 5 g BCAA) vs. placebo (isocaloric maltodextrin) on anaerobic (jumping, sprinting, agility, and the running-based anaerobic sprint test: RAST) and aerobic (Yo-Yo intermittent recovery test level 1) performance, as well as on body composition and selective muscle damage/health-related blood markers in well-trained basketball players during the in-season period. Eighteen basketball players (age: 24.4 ± 6.3 years, height: 185.7 ± 8.0 cm, weight: 85.7 ± 12.8 kg, body fat: 16.5 ± 4.2%) were randomly assigned into two groups: pre-workout supplement (PWS, n = 10) or placebo (PL, n = 8). PWS consumption increased aerobic performance (PWS: 8 ± 6%; PL: -2 ± 6%; p = 0.004) compared to PL. A significant decrease was observed in peak (F = 7.0; p = 0.017), average (F = 10.7; p = 0.005), and minimum power (F = 5.1; p = 0.039) following 4 weeks of supplementation in both groups. No other significant changes were observed between groups (p > 0.05). In conclusion, the consumption of the current PWS over a four-week period appears to positively influence the aerobic performance of well-trained basketball players during the in-season period. However, it does not appear to mitigate the observed decline in anaerobic power, nor does it affect performance in jumping, sprinting, and agility, or alter body composition or selective muscle damage/health-related blood markers.

Pharmacoinformational, gerontoinformational and chemoreactomic analysis of the molecule of citrulline malate, carnitine, sulbutiamine and meldonium to identify the molecular mechanisms of antiasthenic action

The pathophysiology of asthenia is very complex and is associated with chronic kidney disease, heart failure, chronic obstructive pulmonary disease, sarcopenia, bacterial and viral pathogens, micronutrient nutritional imbalances, hypothyroidism, etc. Asthenia can occur with excessive (for a given patient) physical, mental or mental stress and adaptation disorders or be iatrogenic in nature (in particular, due to taking medications that contribute to increased loss of vitamins and microelements), incl. due to unwanted drug interactions. The complex nature of the pathophysiology of asthenia necessitates the use of a differentiated approach aimed at eliminating the main cause of asthenia in a given patient. If asthenia is associated primarily with disorders of energy metabolism, then the pathophysiological treatment is the use of nutrients that support intracellular synthesis - such as citrulline, citrulline malate, the main mechanisms of action of which are supporting the urea cycle, increasing the excretion of ammonium ions, reducing the concentration lactate in the blood. The paper presents the results of a comparative pharmacoinformatic and chemoreactomic analysis of citrulline, citrulline malate (CM), carnitine, sulbutiamine and meldonium. The profile of pharmacological effects of citrulline/CM was significantly different from the profiles of other molecules. For citrulline/CM, cholinergic, antidepressant, and lipid-modifying effects have been identified and an antiasthenic effect has been suggested when used in the treatment of Duchenne muscular dystrophy and for disorders of carbohydrate metabolism. Unlike other molecules, CM and carnitine do not contribute to the loss of vitamins and minerals. Inhibition of the CM serotonin 5HT3A receptor may improve vestibulation because blockers of 5-HT3 receptors concentrated in neurons of the vestibular apparatus, improves tests of balance and walking in an experiment in mice. A positive dose-dependent effect of citrulline and CM on the lifespan of a number of model organisms has been shown. Chemoreactomic analysis of molecular receptor proteins indicated new molecular mechanisms of the antiasthenic action of CM: inhibition of serotonin receptors, calcium sensor protein receptors, chemokine receptors, lipopolysaccharides (toll receptors), nociceptin, glutamate, orexin, purines and prostanoids, biosynthesis of NF-kB and TNFα.

Effects of 3days of citrulline malate supplementation on short-duration repeated sprint running performance in male team sport athletes.

Citrulline malate (CM) is purported to be an ergogenic aid during various types of exercise performance. However, the effects of CM on repeated sprint performance (RSP) are under-explored. In a placebo-controlled, double-blind, counterbalanced cross-over design, male university-level team sport athletes (n=13) performed two familiarization trials, after which CM or placebo (PLA) (8×1g tablets each day) were taken on the 2days prior to, and with breakfast on the morning of, each main experimental trial. The main experimental trials employed a RSP protocol consisting of 10 repetitions of 40m maximal shuttle run test (MST) with a 30s interval between the start of each sprint. Sprint times and heart rate were recorded throughout the MST, and blood lactate concentrations were measured before, immediately after, and 5min after completing the MST. CM resulted in better RSP compared to PLA, as indicated by a lower sprint performance decrement (Sdec: CM, 4.68%±1.82% vs. PLA, 6.10%±1.83%; p=0.03; ES=0.77), which was possibly influenced by the fastest sprint time being faster in CM (CM, 8.16±0.34s vs. PLA, 8.29±0.39s; p=0.011; ES=0.34). There were no differences between CM and PLA in average sprint time (p=0.54), slowest sprint time (p=0.48), blood lactate concentrations (p=0.73) or heart rate (p=0.18), nor was there a condition×time interaction effect across the 10 sprints (p=0.166). Three days of CM supplementation (8g daily) attenuated the sprint performance decrement during short-duration high-intensity exercise in the form of running RSP in male university-level team sport athletes.

The effects of short term citrulline malate supplementation on oxidative stress and muscle damage in trained soccer players

There is some evidence that citrulline malate (CM) limits the deleterious effect of oxidative stress in athletes, but its effect on team sports like soccer is not clear. Thus, the current research is designed to investigate the effect of short-term CM supplementation on oxidative stress and muscle damage markers in trained soccer players. In this randomized double-blind controlled trial, 28 healthy, highly-trained male soccer players were selected and randomly assigned into 2 groups to take 6 g/day CM or placebo for 7 days. Blood samples were then taken in a resting-state at baseline and 24 h after the 7-day supplement intervention; and serum malondialdehyde (MDA), total antioxidant capacity (TAC), catalase (CAT), glutathione (GSH), superoxide dismutase (SOD), lactate dehydrogenase (LDH), creatine kinase (CK), and uric acid levels were measured. Compared to the baseline, CM significantly decreased serum uric acid levels (P = 0.03) and significantly increased serum LDH concentrations (P = 0.002). However, there were no significant changes in serum levels of MDA, CAT, GSH, TAC, SOD, LDH CK, and uric acid compared to the placebo group (P > 0.05). It appears that short-term CM supplementation does not improve oxidative stress and muscle damage in soccer players. Further investigations should be conducted to fully understand the effects of CM on soccer players.

Features of Application of the Optimized Physical Rehabilitation Program in Patients with Coronary Heart Disease

Multisymptomatic coronary heart disease (CHD) remains a leading problem in cardiology. A person’s ability to perform physical work determines their quality of life, especially in patients with existing symptoms of damage to the cardiovascular system. The most advanced approach in the physical rehabilitation of patients with CHD is the use of ergometric testing indicators.
 The aim. To study the influence of the developed method of cycling training on the indicators of cardiopulmonary exercise (CPX) in patients with CHD.
 Materials and methods. We examined 65 men with CHD, I-II functional class stable angina pectoris, mean age 44.6 ± 1.39 years (from 32 to 60 years). The diagnosis was made on the basis of clinical findings, electrocardiography and laboratory examination according to the generally accepted criteria of the European Society of Cardiology.
 Results. The treatment results were evaluated two weeks after the completion of the physical rehabilitation program. Qualitative assessment was performed by using the CPX test with the recording of cardiac bioelectric potentials from 12 leads. The criteria for discontinuation of the test were generally accepted provisions based on WHO recommendations.
 While developing a physical rehabilitation program and predicting the timing of a functional recovery, several factors have to be taken into account that significantly affect the patient’s motor activity and determine the pace and outcome of the rehabilitation process as a whole. Long-term, regular physical activity in patients with CHD with limited coronary reserve have an impact on the mechanisms of cardiac function regulation, synchronization and optimization of the activity of the muscular, cardiovascular and respiratory systems. Systematic training sessions reduce the volume of drug therapy and can improve the patients’ quality of life.
 Conclusions. The use of the proposed individualized uniform interval cycling training combined with the intake of citrulline malate leads to a significant improvement in the achieved load capacity, heart rate, duration of work, total volume of completed work, inotropic reserve index, optimization of coronary blood circulation and improvement of bioenergy metabolism in the myocardium.

Acute Citrulline Malate Supplementation Does Not Improve Anaerobic Capacity in Healthy Young Adults: A Pilot Study

Introduction: The aim of this study was to investigate the potential ergogenic properties of citrulline malate (CM) during a 300-yard shuttle run. Methods: Thirty-two recreationally active subjects (M=24; F=8) participated in a randomized, placebo-controlled, double-blind study. Participants completed baseline testing which consisted of two 300-yard shuttle runs for time. Immediately post-exercise blood lactate was taken via a finger stick. An average of the two trials (time in seconds and blood lactate in mmols/L) were recorded and used for analysis. One week later, participants were randomly assigned to one of four groups (control, placebo, 4 grams CM, or 8 grams of CM) and repeated the same exercise protocol. Data were analyzed using a two-way repeated measures analysis of variance. Results: No main effect for shuttle-run time (F=0.149; p=0.702) or shuttle run time by group interaction was observed (F=0.672; p=0.576). There was a main effect for blood lactate (F=17.079; p<0.001) with lactate accumulation during the pre-test (11.64±2.83 mmol/L) being significantly greater compared to the post-treatment lactate levels (9.65±1.94 mmol/L). There was no blood lactate by group interaction (F=0.867; p=0.47). Conclusions: These results indicated that acute CM supplementation did not improve anaerobic performance in healthy, young adults.

Dietary Arginine and Citrulline Supplements for Cardiovascular Health and Athletic Performance: A Narrative Review.

The global market for nutritional supplements (NS) is growing rapidly, and the use of L-arginine (Arg), L-citrulline (Cit), and citrulline malate (CitMal) supplements has been shown to enhance cardiovascular health and athletic performance. Over the past decade, Arg, Cit, and CitMal supplements have received considerable attention from researchers in the field of exercise nutrition, who have investigated their potential effects on hemodynamic function, endothelial function, aerobic and anaerobic capacity, strength, power, and endurance. Previous studies were reviewed to determine the potential impact of Arg, Cit, and CitMal supplements on cardiovascular health and exercise performance. By synthesizing the existing literature, the study aimed to provide insight into the possible uses and limitations of these supplements for these purposes. The results showed that both recreational and trained athletes did not see improved physical performance or increased nitric oxide (NO) synthesis with 0.075 g or 6 g doses of Arg supplement per body weight. However, 2.4 to 6 g of Cit per day for 7 to 16 days of various NSs had a positive impact, increasing NO synthesis, enhancing athletic performance indicators, and reducing feelings of exertion. The effects of an 8 g acute dose of CitMal supplement were inconsistent, and more research is needed to determine its impact on muscle endurance performance. Based on the positive effects reported in previous studies, further testing is warranted in various populations that may benefit from nutritional supplements, including aerobic and anaerobic athletes, resistance-trained individuals, elderly people, and clinical populations, to determine the impact of different doses, timing of ingestion, and long-term and acute effects of Arg, Cit, and CitMal supplements on cardiovascular health and athletic performance.

Effectiveness of the Use of Citrulline Malate to Increase the Powerlifters Adaptive Potential and Physical Performance

Effectiveness of the Use of Citrulline Malate to Increase the Powerlifters Adaptive Potential and Physical Performance

The Effect of a Single Dose of Citrulline on the Physical Performance of Soccer-Specific Exercise in Adult Elite Soccer Players (A Pilot Randomized Double-Blind Trial)

The purpose of this study was to evaluate the effect of a single intake of citrulline at 3 g and 6 g doses in adult elite soccer players performing sport-specific exercise. This randomized double-blind placebo-controlled study analyzed 18 soccer players from the top divisions of three European countries. Participants were randomized into three groups of six each and performed a field-based soccer-specific test for 18 min. Comparative analysis of heart rate, fatigue and post-exercise recovery was conducted. There were no statistically significant differences in most of the analyzed parameters, nor at any of the time points for lactate concentration. Players' RPE exercise test score did not reveal any differences. Neither a single intake of 3 g nor of 6 g of citrulline malate affected physical performance, subjective feelings of fatigue or post-exercise recovery in adult elite soccer players who performed a soccer-specific test.

Effect of citrulline malate supplementation on muscle function and bioenergetics during short-term repeated bouts of fatiguing exercise

ABSTRACT Citrulline malate (CM) has been shown to improve muscle performance in healthy participants during a single exercise session. Yet, within the framework of exercises repeated at close time interval, the consequences of CM ingestion on mechanical performance are controversial and the bioenergetics side remains undocumented. The aim of this double-blind placebo-controlled study was to evaluate in vivo the effect of short-term (7 doses in 48 h) oral administration of CM upon gastrocnemius muscle function and bioenergetics using non-invasive multimodal NMR techniques in healthy rats. The experimental protocol consisted of two 6-min bouts of fatiguing exercise spaced by an 8-min recovery period. CM treatment did not affect the basal bioenergetics status and increased the half-fatigue time during the first exercise bout. With exercise repetition, it prevented PCr cost alteration and decreased both the glycolytic ATP production and the contractile ATP cost in working muscle, but these changes were not associated to any improvement in mechanical performance. In addition, CM did not influence the replenishment of high-energy phosphorylated compounds during the post-exercise recovery periods. Therefore, short-term CM administration enhances muscle bioenergetics throughout fatiguing bouts of exercise repeated at close time interval but this enhancement does not benefit to mechanical performance.

EFFECT OF A NITRIC OXIDE PRE-WORKOUT SUPPLEMENT ON MUSCULAR ENDURANCE

Introduction: Multi-ingredient dietary supplements have been developed to increase nitric oxide (NO) production, with the expectation of improving resistance training performance. Many of these supplements contain ingredients and/ or ingredient amounts that have yet to be studied for their synergy or efficacy in increasing NO production and thus, resistance training performance. Purpose of the study: A randomized crossover design was used to investigate the effect of a citrulline malate (CM) based non-stimulant nitric oxide pre-workout supplement (NOPWS) blend or placebo on Young Men’s Christian Association (YMCA) bench press performance. Applied Methodology: Thirty minutes were provided between NOPWS or placebo ingestion and YMCA bench press assessment. Pre/post heart rate was taken following each condition. Two- and one-way repeated measures ANOVAs (α = 0.05) were run to determine the effect of each condition on heart rate (HR) and the number of repetitions performed (respectively) during the bench press test. Achieved major results: There was a significant two-way interaction between the treatment and time for HR, F(1, 20) = 6.82, p = .017. Resting HR was significantly higher during the supplement session (M = 74.67, SE = 2.54 bpm) than during the placebo session (M = 69.14, SE = 2.31 bpm), F(1, 20) = 8.19, p = .010, ηp2 = .290. No significant difference was found between conditions for number of repetitions performed. Leads: A specific CM-containing NOPWS blend had no significant effect on a standardized assessment of upper body muscular endurance. Practical implications: These findings highlight the need for consideration of the minimum effective dosage and assimilation timing of each respective ingredient when developing or researching pre-workout supplement blends. Originality/Value: This is the first known research to study the effectiveness of this specific blend of ingredients on resistance training performance. Thus, this study provides necessary foundational knowledge for future research in this area.

Acute and Chronic Citrulline Malate Supplementation on Muscle Contractile Properties and Fatigue Rate of the Quadriceps.

This study compared the acute and chronic impact of citrulline malate (CM) supplementation on muscle contractile properties and fatigue rate of the quadriceps. Eighteen recreationally trained males consumed both a placebo (PL) and CM treatment for two separate dosing periods. The first experimental testing session for each dosing period was considered the baseline day, the second session the acute day, and the third session the chronic day, which followed seven consecutive days of supplementation. All testing sessions included exercising on a cycle ergometer at 50%-60% of their max power output for 30min followed by performing the Thorstensson test on an isokinetic dynamometer. A two-way (Supplement × Time) analysis of variance with repeated measures resulted in no significant interactions (p > .05) (PL: baseline day, acute day, chronic day vs. CM: baseline day, acute day, chronic day) for peak power (in watts) (469 ± 81, 490 ± 97, 502 ± 99 vs. 464 ± 85, 480 ± 103, 501 ± 81); peak torque (in newton meters) (150 ± 26, 157 ± 32, 161 ± 31 vs. 149 ± 27, 156 ± 33, 161 ± 26); fatigue rate (in percentage) (57 ± 9, 57 ± 10, 58 ± 9 vs. 57 ± 10, 56 ± 9, 58 ± 9); and heart rate (in beats per minute) (156 ± 17, 146 ± 13, 146 ± 9 vs. 155 ± 11, 146 ± 11, 146 ± 9). The results of this study suggest that neither acute nor chronic supplementation of CM had an effect on recovery or fatigue rate of the quadriceps.

Citrulline malate transdermal delivery through integrating into polyvinyl alcohol (PVA) nanofibers

Citrulline Malate (CM) is a pre-workout energy supplement, frequently used to reduce fatigue in sports that require high levels of energy. Typically, oral intake should occur at least 2 h before undertaking sport, in order for effects to take place. In this study, we have developed a method for immediate dermal release, which would considerably increase the amount of supplement delivered, in a continuous manner. The method was based on polyvinyl alcohol (PVA)-CM integrated fibers, which were fabricated using an electrospinning technique and which ranged between 168 and 396 nm in diameter. The PVA fibers hosted and released the energetic supplement of up to 5 g of CM, equivalent to 5 doses of 1 gr/day. FTIR and Raman measurements indicated a physical rather than a chemical interaction. PVA-CM systems were of relatively low crystallinity and patched fibers became more flexible when CM was increased. Total experimental time of up to 20 h was proportional to the amount of CM released and followed transport mechanism type II, where the first order Korsmeyer-Peppas model correlated the release results. Hydrolytic degradation took place over 4 steps and was proportional to hydrolytic degradation of polymeric fibers. Theoretical calculations at the level of density functional theory (DFT), using the functional B3LYP with the set of bases 6–311 ++ G (d, p), made it possible to determine the nature of the intermolecular interactions between PVA and CM. Electronic and spectroscopic properties were also determined in order to contribute to and complement molecular characterization.

Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.

Citrulline malate (CitMal) is a dietary supplement that is suggested to enhance strength training performance. However, there is conflicting evidence on this matter. Thus, the purpose of this meta-analysis was to determine whether supplementing with CitMal prior to strength training could increase the total number of repetitions performed before reaching voluntary muscular failure. A systematic search was conducted wherein the inclusion criteria were double-blind, placebo-controlled studies in healthy participants that examined the effect of CitMal on repetitions to failure during upper body and lower body resistance exercises. The Hedges's g standardized mean differences (SMD) between the placebo and CitMal trials were calculated and used in a random effect model. Two separate subanalyses were performed for upper body and lower body exercises. Eight studies, including 137 participants who consisted of strength-trained men (n = 101) and women (n = 26) in addition to untrained men (n = 9), fulfilled the inclusion criteria. Across the studies, 14 single-joint and multijoint exercises were performed with an average of 51 ± 23 total repetitions during 5 ± 3 sets per exercise at ∼70% of one-repetition maximum. Supplementing with 6-8 g of CitMal 40-60min before exercise increased repetitions by 3 ± 5 (6.4 ± 7.9%) compared with placebo (p = .022) with a small SMD (0.196). The subanalysis for the lower body resulted in a tendency for an effect of the supplement (8.1 ± 8.4%, SMD: 0.27, p = .051) with no significant effect for the upper body (5.7 ± 8.4%, SMD: 0.16, p = .131). The current analysis observed a small ergogenic effect of CitMal compared with placebo. Acute CitMal supplementation may, therefore, delay fatigue and enhance muscle endurance during high-intensity strength training.